HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	25189618, 34026424, 24249678, 26679995
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 1140
+	Mm
		140263 HDAC1_MOUSE (1-482): 0: 672: 99.38		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		1082308 HDAC2_HUMAN (1-478): 0: 666: 85.92		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		936386 HDAC2_MOUSE (1-478): 0: 664: 85.71		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		177309 HDAC3_HUMAN (9-434): 0: 574: 57.94		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		1112275 HDAC7_MOUSE (11-410): 6.52e-140: 427: 21.89		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		1082371 HDAC8_HUMAN (32-371): 2.54e-139: 407: 43.11		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Mm
		1112318 HDAC6_MOUSE (11-325): 4.35e-103: 334: 25.69		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Sp
		140681 PHD1_SCHPO (7-415): 0: 524: 52.91		RIK1_SCHPO (12-1094): 0: 679: 18.91
+	Hs
		1014212 HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87