Protein: RL21A
Large ribosomal subunit protein eL21A (60S ribosomal protein L21-A)

Gene: RL21A, RPL21A
Organism: Saccharomyces cerevisiae S288C
Interactions: 198
UniProt ID: Q02753

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol
GO:0022625 - cytosolic large ribosomal subunit

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

524909

HSP71
Heat shock protein SSA1

3

3

High-throughput

0.640

High

434272

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.618

High

684822

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.618

High

393205

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.613

High

410296

RL25
Large ribosomal subunit protein uL23

2

1

High-throughput

0.584

High

433806

RL26A
Large ribosomal subunit protein uL24A

2

2

High-throughput

0.584

High

504378

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.584

High

850164

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

1038411

TMA46
Translation machinery-associated protein 46

2

1

High-throughput

0.584

High

864186

ALB1
Ribosome biogenesis protein ALB1

2

1

Small-scale

0.558

High

1038393

ARX1
Probable metalloprotease ARX1

2

3

Small-scale

0.558

High

923109

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

1030557

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

826766

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

923189

NOG2
Nucleolar GTP-binding protein 2

2

2

Small-scale

0.533

High

1038413

NOP53
Ribosome biogenesis protein NOP53

2

1

Small-scale

0.521

High

671042

SIS1
Protein SIS1

1

0

High-throughput

0.493

High

154217

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.479

High

383184

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

409776

RL24A
Large ribosomal subunit protein eL24A

1

2

High-throughput

0.479

High

415046

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

427414

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.479

High

427603

RLA1
Large ribosomal subunit protein P1A

1

3

High-throughput

0.479

High

427742

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.479

High

430908

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.479

High

432676

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.479

High

432903

RL9A
Large ribosomal subunit protein uL6A

1

2

High-throughput

0.479

High

433067

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.479

High

433277

RL17A
Large ribosomal subunit protein uL22A

1

3

High-throughput

0.479

High

434075

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

434189

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.479

High

434429

RL15A
Large ribosomal subunit protein eL15A

1

1

High-throughput

0.479

High

434640

RL22A
Large ribosomal subunit protein eL22A

1

2

High-throughput

0.479

High

436124

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

436497

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

452592

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

High-throughput

0.479

High

482079

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

2

High-throughput

0.479

High

503199

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.479

High

503427

RL11A
Large ribosomal subunit protein uL5A

1

3

High-throughput

0.479

High

503838

RL27A
Large ribosomal subunit protein eL27A

1

2

High-throughput

0.479

High

503949

RL27B
Large ribosomal subunit protein eL27B

1

2

High-throughput

0.479

High

504551

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.479

High

511269

RL20B
Large ribosomal subunit protein eL20B

1

2

High-throughput

0.479

High

511477

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.479

High

511590

RL44B
Large ribosomal subunit protein eL42B

1

1

High-throughput

0.479

High

512604

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513555

RL1A
Large ribosomal subunit protein uL1A

1

1

High-throughput

0.479

High

513752

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

514053

RL18B
Large ribosomal subunit protein eL18B

1

2

High-throughput

0.479

High

514348

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.479

High

515160

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

528860

RLA3
Large ribosomal subunit protein P1B

1

3

High-throughput

0.479

High

531857

RL4A
Large ribosomal subunit protein uL4A

1

3

High-throughput

0.479

High

545977

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.479

High

570120

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

601113

RL8A
Large ribosomal subunit protein eL8A

1

2

High-throughput

0.479

High

663714

RL24B
Large ribosomal subunit protein eL24B

1

2

High-throughput

0.479

High

689113

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.479

High

689271

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.479

High

712653

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.479

High

739447

ZUO1
Zuotin

1

2

High-throughput

0.479

High

781251

RL14A
Large ribosomal subunit protein eL14A

1

3

High-throughput

0.479

High

792202

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

792564

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

803429

RL14B
Large ribosomal subunit protein eL14B

1

3

High-throughput

0.479

High

804391

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.479

High

806162

NMD3
60S ribosomal export protein NMD3

1

1

High-throughput

0.479

High

812590

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

813962

RBG1
Ribosome-interacting GTPase 1

1

2

High-throughput

0.479

High

814027

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

820948

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

825899

RL34B
Large ribosomal subunit protein eL34B

1

3

High-throughput

0.479

High

831827

RL33B
Large ribosomal subunit protein eL33B

1

2

High-throughput

0.479

High

835871

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

863870

RL17B
Large ribosomal subunit protein uL22B

1

3

High-throughput

0.479

High

879837

RL37A
Large ribosomal subunit protein eL37A

1

2

High-throughput

0.479

High

879884

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.479

High

885065

RL4B
Large ribosomal subunit protein uL4B

1

3

High-throughput

0.479

High

902666

RL9B
Large ribosomal subunit protein uL6B

1

2

High-throughput

0.479

High

902696

RL37B
Large ribosomal subunit protein eL37B

1

2

High-throughput

0.479

High

917678

LSG1
Large subunit GTPase 1

1

2

High-throughput

0.479

High

918324

RL26B
Large ribosomal subunit protein uL24B

1

2

High-throughput

0.479

High

924050

JJJ1
J protein JJJ1

1

2

High-throughput

0.479

High

924179

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

942019

RL22B
Large ribosomal subunit protein eL22B

1

2

High-throughput

0.479

High

1018150

RL34A
Large ribosomal subunit protein eL34A

1

3

High-throughput

0.479

High

1036280

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.479

High

1038395

HMO1
High mobility group protein 1

1

2

High-throughput

0.479

High

1038397

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

1038399

LTN1
E3 ubiquitin-protein ligase listerin

1

1

Small-scale

0.479

High

1038414

CHS5
Chitin biosynthesis protein CHS5

1

1

High-throughput

0.479

High

1038416

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.479

High

1038420

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.479

High

1038421

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.479

High

149914

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383355

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

383855

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

435301

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

442071

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

455222

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

513173

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514790

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

515312

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.458

High

515382

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

553555

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

569849

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

674788

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

689618

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

727264

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

747539

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

748010

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

753541

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

778495

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

796890

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

802340

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

815430

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.458

High

865325

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

874483

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

916859

DXO
Decapping nuclease RAI1

1

0

Small-scale

0.458

High

1033518

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1038403

NOC4
Nucleolar complex protein 4

1

0

High-throughput

0.458

High

1038404

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

1038409

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

509689

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.445

High

819573

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

1038390

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.445

High

381222

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

567704

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.437

High

637266

PWP1
Periodic tryptophan protein 1

1

2

High-throughput

0.437

High

666532

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

677534

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

707960

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

735126

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

738910

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.437

High

780308

EBP2
rRNA-processing protein EBP2

1

1

High-throughput

0.437

High

782420

RPF2
Ribosome biogenesis protein RPF2

1

1

Small-scale

0.437

High

790284

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.437

High

793306

RDH54
DNA repair and recombination protein RDH54

1

3

High-throughput

0.437

High

798696

YB8A
Putative uncharacterized protein YBR285W

1

1

Small-scale

0.437

High

801763

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.437

High

803164

ECM29
Proteasome component ECM29

1

1

High-throughput

0.437

High

809397

STM1
Suppressor protein STM1

1

1

High-throughput

0.437

High

812110

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.437

High

813714

ECM1
Shuttling pre-60S factor ECM1

1

1

High-throughput

0.437

High

815329

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

1

High-throughput

0.437

High

844342

ELP2
Elongator complex protein 2

1

2

High-throughput

0.437

High

844584

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

865715

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

916946

VID30
GID complex subunit 1

1

2

High-throughput

0.437

High

918433

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

922682

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

Small-scale

0.437

High

923863

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.437

High

924317

NOP13
Nucleolar protein 13

1

2

High-throughput

0.437

High

924707

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

Small-scale

0.437

High

925426

FAP1
FKBP12-associated protein 1

1

1

High-throughput

0.437

High

1038389

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

1038391

HAS1
ATP-dependent RNA helicase HAS1

1

3

High-throughput

0.437

High

1038396

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

1038406

RIX7
Ribosome biogenesis ATPase RIX7

1

2

High-throughput

0.437

High

1038418

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

1038400

RQC1
Ribosome quality control complex subunit 1

2

0

Small-scale

0.305

High

1038407

BUD20
Bud site selection protein 20

1

0

Small-scale

0.279

Low

518114

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

594527

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

597543

EF3A
Elongation factor 3A

1

0

High-throughput

0.249

Low

649661

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.249

Low

661554

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

677957

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.249

Low

721408

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.249

Low

746923

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

750758

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

751158

SFC1
Succinate/fumarate mitochondrial transporter

1

0

High-throughput

0.249

Low

791095

NOP4
Nucleolar protein 4

1

0

High-throughput

0.249

Low

798106

OM14
Mitochondrial outer membrane protein OM14

1

0

Small-scale

0.249

Low

798291

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.249

Low

803660

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.249

Low

814371

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.249

Low

824638

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

826059

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.249

Low

826270

SNL1
HSP70 co-chaperone SNL1

1

0

Small-scale

0.249

Low

919551

SDA1
Protein SDA1

1

0

High-throughput

0.249

Low

921158

H1
Histone H1

1

0

High-throughput

0.249

Low

1025012

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

1038388

ELP3
Elongator complex protein 3

1

0

High-throughput

0.249

Low

1038392

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.249

Low

1038394

FIN1
Filament protein FIN1

1

0

Small-scale

0.249

Low

1038398

VBA4
Vacuolar basic amino acid transporter 4

1

0

High-throughput

0.249

Low

1038401

POC1
Proteasome chaperone 1

1

0

High-throughput

0.249

Low

1038402

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.249

Low

1038405

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

1038408

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

1038410

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1038412

TRMB
tRNA

1

0

High-throughput

0.249

Low

1038415

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.249

Low

1038417

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.249

Low

1038419

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.249

Low

671693

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

805080

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025