HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: ZN827 (Q17R98)
Zinc finger protein 827
Gene: ZNF827

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25150861, 23752268
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 1081
+	Hs
		1193248 HDAC8_HUMAN (32-371): 2.54e-139: 407: 43.11		ZSCA2_HUMAN (513-925): 3.07e-101: 333: 10.93
+	Mm
		140211 HDAC1_MOUSE (1-482): 0: 672: 99.38		ZBT7A_MOUSE (362-455): 7.67e-10: 64.7: 36.84
+	Hs
		312063 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZBT7A_HUMAN (362-455): 1.1e-09: 64.3: 36.84
+	Hs
		271762 HDAC1_HUMAN (1-482): 0: 668: 100.00		PRDM1_HUMAN (372-455): 1.8e-09: 63.9: 33.33
+	Hs
		1089316 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZN827_HUMAN (1011-1069): 7.37e-10: 65.6: 33.90
+	Hs
		1038755 HDAC1_HUMAN (1-482): 0: 668: 100.00		ZF64B_HUMAN (372-455): 2.4e-09: 63.5: 34.52
+	Hs
		1251257 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZN461_HUMAN (814-1070): 7.87e-10: 64.7: 23.94
+	Hs
		312081 HDAC2_HUMAN (1-478): 0: 666: 85.92		ZBT7A_HUMAN (362-455): 1.1e-09: 64.3: 36.84
+	Hs
		271780 HDAC2_HUMAN (1-478): 0: 666: 85.92		PRDM1_HUMAN (372-455): 1.8e-09: 63.9: 33.33
+	Mm
		936395 HDAC2_MOUSE (1-478): 0: 664: 85.71		PRDM1_MOUSE (372-455): 1.11e-09: 64.7: 33.33
+	Hs
		177160 HDAC3_HUMAN (9-434): 0: 574: 57.94		ZBT7A_HUMAN (362-455): 1.1e-09: 64.3: 36.84