Protein: LGUL
Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)

Gene: LGUL, GLO1
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q04760

Gene Ontology (top 5):
GO:0004462 - lactoylglutathione lyase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1048312

WDR72
WD repeat-containing protein 72

2

1

High-throughput

0.584

High

563660

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

1048334

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

2

0

High-throughput

0.559

High

1048303

SOS2
Son of sevenless homolog 2

2

0

High-throughput

0.547

High

1048337

SHOC2
Leucine-rich repeat protein SHOC-2

2

0

High-throughput

0.547

High

1048340

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.541

High

361226

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

487219

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

783564

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

1048322

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

1048331

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.536

High

1048338

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

212020

M3K13
Mitogen-activated protein kinase kinase kinase 13

1

0

High-throughput

0.518

High

213907

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

370641

FOS
Protein c-Fos

1

0

High-throughput

0.513

High

1048301

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

1048321

TRPM4
Transient receptor potential cation channel subfamily M member 4

1

0

High-throughput

0.513

High

1038426

TIE2
Angiopoietin-1 receptor

1

2

High-throughput

0.500

High

1048311

PUS10
tRNA pseudouridine synthase Pus10

1

0

High-throughput

0.493

High

1048328

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.489

High

893831

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

1048320

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

Small-scale

0.480

High

1048329

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.479

High

341557

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

588518

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606668

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

791316

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

970374

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1032912

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

1048305

MERTK
Tyrosine-protein kinase Mer

1

1

High-throughput

0.479

High

1048307

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1048308

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1048309

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1048315

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1048317

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1048325

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1048326

OPTN
Optineurin

1

1

High-throughput

0.479

High

164319

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

170097

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

210555

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.458

High

293595

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

315491

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319694

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

459274

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

560373

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

609989

VGFR1
Vascular endothelial growth factor receptor 1

1

0

High-throughput

0.458

High

681347

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

695267

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714052

PML
Protein PML

1

0

High-throughput

0.458

High

719315

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

768009

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

774306

BASI
Basigin

1

0

High-throughput

0.458

High

830601

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

862059

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

1048302

SRS11
Serine/arginine-rich splicing factor 11

1

0

High-throughput

0.458

High

1048304

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

1048310

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1048316

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1048318

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1048319

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1048323

CLC4D
C-type lectin domain family 4 member D

1

0

High-throughput

0.458

High

1048324

ASB12
Ankyrin repeat and SOCS box protein 12

1

0

High-throughput

0.458

High

1048327

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1048335

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1048336

UBQL1
Ubiquilin-1

1

0

High-throughput

0.458

High

1048339

5MP1
eIF5-mimic protein 1

1

0

High-throughput

0.458

High

529674

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

838068

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

1048332

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1048333

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.426

High

1048314

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.417

High

886782

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

1048330

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.279

Low

1048313

MROH9
Maestro heat-like repeat-containing protein family member 9

1

0

High-throughput

0.269

Low

292118

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.249

Low

353271

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1048306

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025