HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.770

The method score is based on:

Property Details
Experiments 25314079, 12724404, 12398767, 9804427, 10640275, 11784859, 33961781, 14593184, 12453419, 11602581, 11118440, 18059533, 17827154, 21258344, 19182791, 26496610, 28514442, 12943729, 12920132, 10220385 and 20 others

more...
Identification Methods affinity chromatography technology, biochemical, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, cross-linking study
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 10 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 482
Hs

1 1273
+ Mm
+ Hs
+ Mm
+ Mm
+ Ce
+ Sp
+ Ce
+ Sp
+ Dm
+ Dm
+ At
+ Hs
+ Hs
+ Sc
+ At
+ Dm
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024