Protein: DET1
DET1 homolog (De-etiolated-1 homolog)

Gene: DET1
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q7L5Y6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0016567 - protein ubiquitination
GO:0031461 - cullin-RING ubiquitin ligase complex
GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
GO:0031625 - ubiquitin protein ligase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157786

DDB1
DNA damage-binding protein 1

9

2

Small-scale

0.750

High

1114916

CUL4A
Cullin-4A

7

2

Small-scale

0.743

High

1272648

COP1
E3 ubiquitin-protein ligase COP1

12

0

Small-scale

0.725

High

1115272

CUL4B
Cullin-4B

4

2

Small-scale

0.703

High

370710

FOS
Protein c-Fos

4

4

High-throughput

0.694

High

1272650

TRIB2
Tribbles homolog 2

3

2

High-throughput

0.675

High

1272665

TRIB1
Tribbles homolog 1

3

3

High-throughput

0.675

High

584112

FOSL2
Fos-related antigen 2

3

3

High-throughput

0.667

High

832489

ETV5
ETS translocation variant 5

3

3

High-throughput

0.667

High

896490

ETV1
ETS translocation variant 1

3

3

High-throughput

0.667

High

909335

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

3

Small-scale

0.667

High

1272654

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

3

Small-scale

0.667

High

1272676

CSN7B
COP9 signalosome complex subunit 7b

3

1

High-throughput

0.667

High

1272683

CSN7A
COP9 signalosome complex subunit 7a

3

1

High-throughput

0.667

High

1272672

DDA1
DET1- and DDB1-associated protein 1

4

0

Small-scale

0.664

High

1272652

CSN5
COP9 signalosome complex subunit 5

3

0

High-throughput

0.638

High

603662

JUNB
Transcription factor JunB

2

1

High-throughput

0.628

High

958665

CSN2
COP9 signalosome complex subunit 2

2

2

High-throughput

0.628

High

1094362

CSN1
COP9 signalosome complex subunit 1

2

1

High-throughput

0.628

High

1272661

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

3

High-throughput

0.628

High

1272689

CSN3
COP9 signalosome complex subunit 3

2

2

High-throughput

0.628

High

1272471

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.602

High

1272670

CSN4
COP9 signalosome complex subunit 4

2

0

High-throughput

0.602

High

461642

HS90A
Heat shock protein HSP 90-alpha

2

2

High-throughput

0.584

High

468536

HS90B
Heat shock protein HSP 90-beta

2

3

High-throughput

0.584

High

731418

STIP1
Stress-induced-phosphoprotein 1

2

2

High-throughput

0.584

High

1272645

STK40
Serine/threonine-protein kinase 40

2

3

High-throughput

0.574

High

1272678

CYBP
Calcyclin-binding protein

2

0

High-throughput

0.559

High

537405

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

1272664

TRIB3
Tribbles homolog 3

1

3

High-throughput

0.536

High

1272641

NUDC3
NudC domain-containing protein 3

2

2

High-throughput

0.533

High

617316

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

High-throughput

0.513

High

671815

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

1272644

SIX5
Homeobox protein SIX5

1

0

High-throughput

0.513

High

1272667

CSN8
COP9 signalosome complex subunit 8

1

0

High-throughput

0.513

High

846918

ETV4
ETS translocation variant 4

1

3

High-throughput

0.500

High

1272684

DNJB4
DnaJ homolog subfamily B member 4

1

1

High-throughput

0.489

High

144284

ACACB
Acetyl-CoA carboxylase 2

1

4

High-throughput

0.479

High

191688

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.479

High

194579

KDM6A
Lysine-specific demethylase 6A

1

2

Small-scale

0.479

High

215321

TXNL1
Thioredoxin-like protein 1

1

3

High-throughput

0.479

High

346653

TTC4
Tetratricopeptide repeat protein 4

1

7

High-throughput

0.479

High

430079

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

528286

THIO
Thioredoxin

1

1

High-throughput

0.479

High

573546

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

578305

ETS2
Protein C-ets-2

1

3

Small-scale

0.479

High

587712

DESP
Desmoplakin

1

1

High-throughput

0.479

High

717519

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

727865

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

983862

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

1007107

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.479

High

1036756

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

1157653

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

1193541

CRY2
Cryptochrome-2

1

1

Small-scale

0.479

High

1272688

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1272693

MAGD1
Melanoma-associated antigen D1

1

1

High-throughput

0.479

High

134071

IPO5
Importin-5

1

0

High-throughput

0.458

High

159369

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

High-throughput

0.458

High

316407

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.458

High

347132

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

402781

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

408959

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

416752

TYSY
Thymidylate synthase

1

0

High-throughput

0.458

High

447157

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

455810

H10
Histone H1.0

1

0

High-throughput

0.458

High

508191

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

637597

FLNA
Filamin-A

1

0

High-throughput

0.458

High

716440

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

776889

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.458

High

866740

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.458

High

872467

SOX2
Transcription factor SOX-2

1

0

Small-scale

0.458

High

916679

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

927044

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

934788

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

981872

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

985736

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

991053

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.458

High

992822

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

1028255

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1035517

CENPE
Centromere-associated protein E

1

0

High-throughput

0.458

High

1037232

H11
Histone H1.1

1

0

High-throughput

0.458

High

1100617

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.458

High

1119477

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.458

High

1148708

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.458

High

1195519

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

0

High-throughput

0.458

High

1226772

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.458

High

1239858

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1272643

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1272647

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.458

High

1272651

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1272653

GLMN
Glomulin

1

0

High-throughput

0.458

High

1272658

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.458

High

1272659

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1272671

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.458

High

1272682

RNF14
E3 ubiquitin-protein ligase RNF14

1

0

Small-scale

0.458

High

1272685

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.458

High

1272686

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1272690

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

76550

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

2

High-throughput

0.437

High

124803

AIP
AH receptor-interacting protein

1

2

High-throughput

0.437

High

425817

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

High-throughput

0.437

High

425921

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.437

High

547159

PYC
Pyruvate carboxylase, mitochondrial

1

4

High-throughput

0.437

High

895926

F10A1
Hsc70-interacting protein

1

5

High-throughput

0.437

High

1038650

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.437

High

1094204

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.437

High

1105983

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.437

High

1142314

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.437

High

1191434

GRDN
Girdin

1

2

High-throughput

0.437

High

1198784

Q53FC7
Heat shock 70 kDa protein 6

1

1

High-throughput

0.437

High

1245554

Q6PK50
HSP90AB1 protein

1

3

High-throughput

0.437

High

1272639

PHLB2
Pleckstrin homology-like domain family B member 2

1

1

High-throughput

0.437

High

1272649

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

1272655

TTC28
Tetratricopeptide repeat protein 28

1

3

High-throughput

0.437

High

1272656

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.437

High

1272663

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

1272666

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.437

High

1272669

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.437

High

1272674

UN45A
Protein unc-45 homolog A

1

3

High-throughput

0.437

High

1272679

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.437

High

1272691

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.437

High

1272692

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.437

High

1210888

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.407

High

423797

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

1272687

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

1272694

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.279

Low

51090

PKHG3
Pleckstrin homology domain-containing family G member 3

1

0

High-throughput

0.249

Low

76488

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

0

High-throughput

0.249

Low

175100

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.249

Low

176682

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.249

Low

209047

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.249

Low

322958

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.249

Low

350607

TXD12
Thioredoxin domain-containing protein 12

1

0

High-throughput

0.249

Low

480839

LEG1
Galectin-1

1

0

High-throughput

0.249

Low

858965

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

876039

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.249

Low

903724

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

937606

CAD15
Cadherin-15

1

0

High-throughput

0.249

Low

952589

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.249

Low

1010655

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1017788

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.249

Low

1026109

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.249

Low

1161017

FSCN1
Fascin

1

0

High-throughput

0.249

Low

1213756

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.249

Low

1226947

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1250348

LIGO4
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

1

0

High-throughput

0.249

Low

1257727

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.249

Low

1258117

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1272640

NOXA1
NADPH oxidase activator 1

1

0

High-throughput

0.249

Low

1272642

MSRB3
Methionine-R-sulfoxide reductase B3

1

0

High-throughput

0.249

Low

1272646

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

High-throughput

0.249

Low

1272657

KBP
KIF-binding protein

1

0

High-throughput

0.249

Low

1272660

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.249

Low

1272662

LRRC7
Leucine-rich repeat-containing protein 7

1

0

High-throughput

0.249

Low

1272668

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1272673

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.249

Low

1272675

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

1272677

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.249

Low

1272680

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.249

Low

1272681

Q9NWG3
cDNA FLJ10043 fis, clone HEMBA1001085

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025