HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: HM20A (Q9NP66)
High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1)
Gene: HMG20A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 21258344, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 347
+	Hs
		1270459 HDAC2_HUMAN (1-478): 0: 666: 85.92		HM20A_HUMAN (1-347): 9.42e-80: 249: 100.00
+	Hs
		1038764 HDAC1_HUMAN (1-482): 0: 668: 100.00		HM20B_HUMAN (60-345): 5.54e-68: 217: 50.00
+	Hs
		1270484 HDAC2_HUMAN (1-478): 0: 666: 85.92		HM20B_HUMAN (60-345): 5.54e-68: 217: 50.00
+	Hs
		1038602 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		1038645 HDAC1_HUMAN (1-482): 0: 668: 100.00		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Hs
		1270357 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMCE1_HUMAN (109-299): 6.51e-34: 130: 20.00
+	Hs
		1270390 HDAC2_HUMAN (1-478): 0: 666: 85.92		CIC_HUMAN (27-227): 1.8e-32: 130: 17.24
+	Mm
		140321 HDAC1_MOUSE (1-482): 0: 672: 99.38		TF7L1_MOUSE (12-328): 6.49e-31: 124: 13.13
+	Mm
		140273 HDAC1_MOUSE (1-482): 0: 672: 99.38		Q60I23_MOUSE (65-269): 2.85e-31: 122: 15.21
+	Mm
		140241 HDAC1_MOUSE (1-482): 0: 672: 99.38		SOX2_MOUSE (65-269): 5.13e-31: 121: 15.21
+	Mm
		140296 HDAC1_MOUSE (1-482): 0: 672: 99.38		NSD2_MOUSE (4-345): 1.72e-29: 121: 13.56
+	Hs
		818023 HDAC1_HUMAN (1-482): 0: 668: 100.00		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Hs
		297491 HDAC1_HUMAN (1-482): 0: 668: 100.00		TOX4_HUMAN (4-265): 3.04e-29: 120: 15.99
+	Hs
		818314 HDAC2_HUMAN (1-478): 0: 666: 85.92		SOX2_HUMAN (68-269): 3.13e-31: 121: 15.42
+	Mm
		936399 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q60I23_MOUSE (65-269): 2.85e-31: 122: 15.21
+	Mm
		818688 HDAC2_MOUSE (1-478): 0: 664: 85.71		SOX2_MOUSE (65-269): 5.13e-31: 121: 15.21
+	Hs
		449714 HDAC1_HUMAN (1-482): 0: 668: 100.00		HMGB1_HUMAN (97-265): 2.13e-15: 76.2: 19.65
+	Mm
		57643 HDAC1_MOUSE (1-482): 0: 672: 99.38		A2AWT7_MOUSE (59-266): 2.19e-10: 63.9: 16.35
+	Dm
		1098074 HDAC1_DROME (6-477): 0: 658: 77.33		HMG2_DROME (98-265): 3.54e-15: 77.8: 17.92
+	Hs
		567691 HDAC1_HUMAN (1-482): 0: 668: 100.00		UBF1_HUMAN (59-266): 2.79e-09: 60.4: 16.35