HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: HM20B (Q9P0W2)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35)
Gene: HMG20B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	26186194, 28514442, 12032298, 33961781, 26496610, 35271311, 34709266, 21258344, 23752268
Identification Methods	affinity chromatography technology, biochemical, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 317
+	Hs
		1270484 HDAC2_HUMAN (1-478): 0: 666: 85.92		HM20B_HUMAN (1-317): 2.24e-73: 230: 100.00
+	Hs
		1038736 HDAC1_HUMAN (1-482): 0: 668: 100.00		HM20A_HUMAN (3-313): 3.45e-57: 189: 46.35
+	Hs
		1270459 HDAC2_HUMAN (1-478): 0: 666: 85.92		HM20A_HUMAN (3-313): 3.45e-57: 189: 46.35
+	Mm
		140296 HDAC1_MOUSE (1-482): 0: 672: 99.38		NSD2_MOUSE (28-282): 2.28e-34: 134: 14.29
+	Hs
		331809 HDAC1_HUMAN (1-482): 0: 668: 100.00		NSD2_HUMAN (2-282): 1.75e-30: 123: 13.01
+	Hs
		331858 HDAC2_HUMAN (1-478): 0: 666: 85.92		NSD2_HUMAN (2-282): 1.75e-30: 123: 13.01
+	Hs
		1038602 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMCE1_HUMAN (74-315): 3.79e-29: 117: 21.18
+	Hs
		1270357 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMCE1_HUMAN (74-315): 3.79e-29: 117: 21.18
+	Mm
		140241 HDAC1_MOUSE (1-482): 0: 672: 99.38		SOX2_MOUSE (37-153): 1.1e-26: 109: 26.50
+	Mm
		140273 HDAC1_MOUSE (1-482): 0: 672: 99.38		Q60I23_MOUSE (37-153): 5.51e-27: 109: 26.50
+	Hs
		297491 HDAC1_HUMAN (1-482): 0: 668: 100.00		TOX4_HUMAN (15-201): 2.03e-25: 108: 20.31
+	Hs
		818023 HDAC1_HUMAN (1-482): 0: 668: 100.00		SOX2_HUMAN (37-153): 1.65e-26: 108: 24.79
+	Hs
		818314 HDAC2_HUMAN (1-478): 0: 666: 85.92		SOX2_HUMAN (37-153): 1.65e-26: 108: 24.79
+	Mm
		818688 HDAC2_MOUSE (1-478): 0: 664: 85.71		SOX2_MOUSE (37-153): 1.1e-26: 109: 26.50
+	Mm
		936399 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q60I23_MOUSE (37-153): 5.51e-27: 109: 26.50
+	Hs
		449714 HDAC1_HUMAN (1-482): 0: 668: 100.00		HMGB1_HUMAN (64-163): 1.04e-11: 65.3: 25.49
+	Dm
		1098074 HDAC1_DROME (6-477): 0: 658: 77.33		HMG2_DROME (69-167): 1.15e-11: 66.9: 24.75
+	Hs
		177229 HDAC3_HUMAN (9-434): 0: 574: 57.94		SOX2_HUMAN (37-153): 1.65e-26: 108: 24.79
+	Mm
		1142019 Q9JM08_MOUSE (9-434): 0: 568: 57.71		Q60I23_MOUSE (37-153): 5.51e-27: 109: 26.50
+	Sc
		693061 RPD3_YEAST (8-421): 0: 580: 61.48		NHP10_YEAST (53-176): 5.58e-12: 65.6: 20.16