HitPredict

Interactor 1: LAPM5 (Q13571)
Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)
Gene: LAPTM5

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	33961781, 22009753
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031410 - cytoplasmic vesicle GO:0032991 - protein-containing complex GO:2000646 - positive regulation of receptor catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 903
+	Hs
		1039515 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125438 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1039512 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808116 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808158 Q5TBB8_HUMAN (1-262): 2.03e-151: 424: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1039518 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		808355 LAPM5_MOUSE (1-262): 4.27e-144: 405: 79.01		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38