HitPredict

Interactor 1: LAPM5 (Q13571)
Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)
Gene: LAPTM5

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 748
+	Mm
		808355 LAPM5_MOUSE (1-262): 4.27e-144: 405: 79.01		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Hs
		808116 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		808158 Q5TBB8_HUMAN (1-262): 2.03e-151: 424: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		1039512 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125438 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1039511 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1039515 LAPM5_HUMAN (1-262): 2.03e-151: 424: 100.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47