Protein: TOP2B
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)

Gene: TOP2B
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q02880

Gene Ontology (top 5):
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000819 - sister chromatid segregation
GO:0001764 - neuron migration
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542468

TOP2A
DNA topoisomerase 2-alpha

3

16

Small-scale

0.853

High

487210

PARP1
Poly [ADP-ribose] polymerase 1

4

4

Small-scale

0.686

High

1039546

CUL5
Cullin-5

3

5

High-throughput

0.675

High

1039532

PIAS4
E3 SUMO-protein ligase PIAS4

2

3

Small-scale

0.639

High

993508

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.636

High

1039494

HDAC1
Histone deacetylase 1

2

5

Small-scale

0.636

High

686682

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

2

1

High-throughput

0.628

High

1039593

ASB3
Ankyrin repeat and SOCS box protein 3

2

3

High-throughput

0.628

High

413664

P53
Cellular tumor antigen p53

2

2

Small-scale

0.624

High

1039559

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.618

High

395951

ESR1
Estrogen receptor

2

11

Small-scale

0.611

High

446926

NPM
Nucleophosmin

2

2

High-throughput

0.611

High

521653

H14
Histone H1.4

2

1

High-throughput

0.611

High

1004465

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

Small-scale

0.595

High

994992

CSK2B
Casein kinase II subunit beta

2

2

Small-scale

0.586

High

128990

MEN1
Menin

2

2

High-throughput

0.584

High

259821

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

345693

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

10

High-throughput

0.584

High

371813

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

588507

RFA2
Replication protein A 32 kDa subunit

2

3

High-throughput

0.584

High

695257

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

767999

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.584

High

980707

H2B1C
Histone H2B type 1-C/E/F/G/I

2

17

High-throughput

0.584

High

998231

H31
Histone H3.1

2

13

High-throughput

0.584

High

1016788

H33
Histone H3.3

2

13

High-throughput

0.584

High

1039499

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

9

High-throughput

0.584

High

1039553

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.576

High

520561

RARA
Retinoic acid receptor alpha

1

9

Small-scale

0.561

High

540843

ERG
Transcriptional regulator ERG

1

1

Small-scale

0.561

High

890452

RBP2
E3 SUMO-protein ligase RanBP2

1

4

Small-scale

0.561

High

1039543

HDAC2
Histone deacetylase 2

1

5

Small-scale

0.561

High

983767

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

Small-scale

0.559

High

648351

USF1
Upstream stimulatory factor 1

1

4

Small-scale

0.554

High

857420

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.554

High

391228

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

481246

HMGB1
High mobility group protein B1

1

10

High-throughput

0.536

High

501969

H2AZ
Histone H2A.Z

1

9

High-throughput

0.536

High

541960

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

601637

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

662557

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.536

High

693702

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

787985

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.536

High

859238

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

969803

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

1006348

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.536

High

1013045

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

1

High-throughput

0.536

High

1014072

CBX1
Chromobox protein homolog 1

1

4

High-throughput

0.536

High

1039484

CALD1
Caldesmon

1

8

High-throughput

0.536

High

1039485

SSRP1
FACT complex subunit SSRP1

1

14

High-throughput

0.536

High

1039495

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.536

High

1039496

CAPR1
Caprin-1

1

4

High-throughput

0.536

High

1039500

NUMA1
Nuclear mitotic apparatus protein 1

1

5

High-throughput

0.536

High

1039505

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.536

High

1039510

H2B2E
Histone H2B type 2-E

1

17

High-throughput

0.536

High

1039514

DJC21
DnaJ homolog subfamily C member 21

1

1

High-throughput

0.536

High

1039520

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.536

High

1039526

COX15
Heme A synthase COX15

1

1

High-throughput

0.536

High

1039536

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.536

High

1039540

PSPC1
Paraspeckle component 1

1

8

High-throughput

0.536

High

1039548

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.536

High

1039557

VRK1
Serine/threonine-protein kinase VRK1

1

4

High-throughput

0.536

High

1039567

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1039569

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1039581

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

1039582

FOXD3
Forkhead box protein D3

1

8

High-throughput

0.536

High

1039585

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.536

High

1039589

KLH20
Kelch-like protein 20

1

2

High-throughput

0.536

High

1039591

ZN451
E3 SUMO-protein ligase ZNF451

1

1

High-throughput

0.536

High

558058

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.515

High

1039554

MED15
Mediator of RNA polymerase II transcription subunit 15

1

6

High-throughput

0.515

High

884069

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

932996

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.513

High

507856

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

799012

BRCA1
Breast cancer type 1 susceptibility protein

1

4

Small-scale

0.501

High

964232

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

1039545

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

842639

WASP
Actin nucleation-promoting factor WAS

1

4

Small-scale

0.484

High

991298

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.481

High

1039542

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.481

High

96665

E9PAV9
G patch domain-containing protein 4

1

1

High-throughput

0.479

High

125415

LEG9
Galectin-9

1

2

High-throughput

0.479

High

130943

HIP1
Huntingtin-interacting protein 1

1

4

High-throughput

0.479

High

131972

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

138074

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

Small-scale

0.479

High

140879

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

157262

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

190879

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

222957

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

241448

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

247838

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

248286

HBP1
HMG box-containing protein 1

1

10

High-throughput

0.479

High

256837

H2B1K
Histone H2B type 1-K

1

17

High-throughput

0.479

High

272092

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

316816

MTA2
Metastasis-associated protein MTA2

1

3

Small-scale

0.479

High

330885

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

385665

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.479

High

411769

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

425455

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

463465

LYN
Tyrosine-protein kinase Lyn

1

2

High-throughput

0.479

High

464918

SP1
Transcription factor Sp1

1

1

Small-scale

0.479

High

472665

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.479

High

519959

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

643794

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

674142

BRD2
Bromodomain-containing protein 2

1

14

High-throughput

0.479

High

680322

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

697081

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

701135

PSB5
Proteasome subunit beta type-5

1

2

Small-scale

0.479

High

714043

PML
Protein PML

1

5

Small-scale

0.479

High

731216

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

789476

PPARG
Peroxisome proliferator-activated receptor gamma

1

10

Small-scale

0.479

High

799855

COIL
Coilin

1

1

High-throughput

0.479

High

830594

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

842338

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

867058

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

877092

KC1D
Casein kinase I isoform delta

1

2

Small-scale

0.479

High

878988

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

883510

CENPA
Histone H3-like centromeric protein A

1

13

High-throughput

0.479

High

886461

CTCF
Transcriptional repressor CTCF

1

1

Small-scale

0.479

High

904620

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

907389

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

910019

RND2
Rho-related GTP-binding protein RhoN

1

9

High-throughput

0.479

High

937219

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

10

High-throughput

0.479

High

941140

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

955076

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

961266

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.479

High

961971

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

977949

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

978885

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

979527

H4
Histone H4

1

3

High-throughput

0.479

High

982629

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

984724

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

1008690

RED1
Double-stranded RNA-specific editase 1

1

9

High-throughput

0.479

High

1035548

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1039480

ENL
Protein ENL

1

4

High-throughput

0.479

High

1039482

ERCC6
DNA excision repair protein ERCC-6

1

16

Small-scale

0.479

High

1039486

EP300
Histone acetyltransferase p300

1

12

High-throughput

0.479

High

1039487

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.479

High

1039488

FOXC1
Forkhead box protein C1

1

10

High-throughput

0.479

High

1039489

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

1039490

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

1039491

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.479

High

1039492

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.479

High

1039493

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1039498

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1039501

CUL7
Cullin-7

1

2

High-throughput

0.479

High

1039502

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1039503

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1039504

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

1039506

ZMY11
Zinc finger MYND domain-containing protein 11

1

8

Small-scale

0.479

High

1039508

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1039509

IF16
Gamma-interferon-inducible protein 16

1

3

High-throughput

0.479

High

1039511

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.479

High

1039512

MIDN
Midnolin

1

1

High-throughput

0.479

High

1039513

PDCD4
Programmed cell death protein 4

1

1

High-throughput

0.479

High

1039516

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

1

High-throughput

0.479

High

1039517

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

1039518

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

1039519

H3C
Histone H3.3C

1

13

High-throughput

0.479

High

1039528

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1039529

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1039530

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.479

High

1039534

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1039535

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1039537

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.479

High

1039538

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1039539

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1039541

DDB2
DNA damage-binding protein 2

1

10

High-throughput

0.479

High

1039544

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

1039547

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

1039549

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1039550

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

1039551

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1039552

RHOV
Rho-related GTP-binding protein RhoV

1

8

High-throughput

0.479

High

1039555

BARD1
BRCA1-associated RING domain protein 1

1

2

Small-scale

0.479

High

1039556

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

11

High-throughput

0.479

High

1039558

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.479

High

1039560

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.479

High

1039561

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

1039563

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

6

High-throughput

0.479

High

1039571

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

1039572

RHOF
Rho-related GTP-binding protein RhoF

1

7

High-throughput

0.479

High

1039573

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1039575

ANLN
Anillin

1

1

High-throughput

0.479

High

1039576

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1039577

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.479

High

1039583

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

1039586

CE164
Centrosomal protein of 164 kDa

1

7

High-throughput

0.479

High

1039588

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.479

High

1039590

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1039592

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

219157

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.460

High

282371

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.458

High

298363

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

358669

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.458

High

408821

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

659672

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.458

High

935492

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.458

High

1039497

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1039521

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.458

High

1039523

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1039525

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

1039566

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1039574

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.458

High

1039579

DYH2
Dynein axonemal heavy chain 2

1

0

High-throughput

0.458

High

1039587

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

1039594

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

429756

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

911557

NCBP2
Nuclear cap-binding protein subunit 2

1

8

High-throughput

0.445

High

985619

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.445

High

1039483

KPCD
Protein kinase C delta type

1

6

Small-scale

0.445

High

1039515

GPTC4
G patch domain-containing protein 4

1

1

High-throughput

0.445

High

1039578

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

1039584

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.445

High

318734

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

1039507

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.437

High

1039524

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1039527

OTU6A
OTU domain-containing protein 6A

1

1

Small-scale

0.437

High

1039531

SPICE
Spindle and centriole-associated protein 1

1

1

High-throughput

0.437

High

1039562

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

1039564

YTHD1
YTH domain-containing family protein 1

1

3

High-throughput

0.437

High

1039565

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

1039568

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

1039570

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1039533

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

886775

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

58805

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

1039481

UPAR
Urokinase plasminogen activator surface receptor

2

0

High-throughput

0.328

High

460254

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

Small-scale

0.292

High

278492

VAMP4
Vesicle-associated membrane protein 4

1

0

High-throughput

0.269

Low

1039522

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1039580

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025