HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXW9 (Q5XUX1)
F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)
Gene: FBXW9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	33961781, 29103612, 37028429, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 458
+	Mm
		1257398 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW7_MOUSE (28-410): 4.02e-76: 253: 16.29
+	Hs
		1041133 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW7_HUMAN (28-410): 1.22e-75: 252: 16.03
+	Hs
		1043499 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBXW7_HUMAN (28-410): 1.22e-75: 252: 16.03
+	Hs
		903206 CUL1_HUMAN (1-776): 0: 911: 100.00		WDR5_HUMAN (35-203): 9.39e-13: 71.1: 10.73
+	Mm
		1112933 CUL1_MOUSE (1-776): 0: 912: 99.87		FBW1A_MOUSE (51-222): 1.4e-11: 68.4: 10.38
+	Hs
		1041292 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1A_HUMAN (51-222): 1.02e-11: 69.1: 10.38
+	Hs
		1041266 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1B_HUMAN (51-222): 2.76e-11: 67.6: 10.38
+	Hs
		1043114 CUL4A_HUMAN (7-776): 0: 781: 30.41		POC1B_HUMAN (253-457): 9.53e-47: 170: 13.89
+	Hs
		1043469 CUL4B_HUMAN (7-776): 0: 773: 29.90		POC1B_HUMAN (253-457): 9.53e-47: 170: 13.89
+	Dm
		1097201 CUL1_DROME (4-776): 0: 770: 61.98		Q9VDE3_DROME (292-458): 1.16e-37: 145: 22.99
+	Hs
		1043157 CUL4A_HUMAN (7-776): 0: 781: 30.41		SNR40_HUMAN (1-248): 1.16e-20: 94.9: 11.83
+	Hs
		1043509 CUL4B_HUMAN (7-776): 0: 773: 29.90		SNR40_HUMAN (1-248): 1.16e-20: 94.9: 11.83
+	Hs
		792982 CUL4A_HUMAN (7-776): 0: 781: 30.41		LIS1_HUMAN (377-458): 1.64e-16: 83: 18.61
+	Hs
		1043085 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5B_HUMAN (372-458): 2.99e-15: 78.4: 17.58
+	Hs
		903208 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5_HUMAN (35-203): 9.39e-13: 71.1: 10.73
+	Hs
		1043441 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5B_HUMAN (372-458): 2.99e-15: 78.4: 17.58
+	Hs
		1043319 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1A_HUMAN (51-222): 1.02e-11: 69.1: 10.38
+	Hs
		1043297 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1B_HUMAN (51-222): 2.76e-11: 67.6: 10.38
+	Hs
		903209 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5_HUMAN (35-203): 9.39e-13: 71.1: 10.73
+	Hs
		1043637 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBW1B_HUMAN (51-222): 2.76e-11: 67.6: 10.38