Protein: STX3
Syntaxin-3

Gene: STX3
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q13277

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001750 - photoreceptor outer segment
GO:0001917 - photoreceptor inner segment
GO:0005484 - SNAP receptor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1100666

STXB2
Syntaxin-binding protein 2

7

20

Small-scale

0.962

High

1097769

STX5
Syntaxin-5

7

20

High-throughput

0.960

High

1087097

STX4
Syntaxin-4

6

17

High-throughput

0.949

High

963413

STXB1
Syntaxin-binding protein 1

6

20

Small-scale

0.945

High

1100716

SNAB
Beta-soluble NSF attachment protein

6

20

High-throughput

0.943

High

989325

VAMP2
Vesicle-associated membrane protein 2

6

20

Small-scale

0.942

High

1100713

VAMP8
Vesicle-associated membrane protein 8

6

20

Small-scale

0.940

High

1100667

VAMP3
Vesicle-associated membrane protein 3

5

20

Small-scale

0.923

High

189548

STX7
Syntaxin-7

4

17

High-throughput

0.895

High

192248

YKT6
Synaptobrevin homolog YKT6

4

20

High-throughput

0.892

High

226020

STX6
Syntaxin-6

4

20

High-throughput

0.892

High

1100738

STX8
Syntaxin-8

4

20

High-throughput

0.892

High

331862

GOSR1
Golgi SNAP receptor complex member 1

4

10

High-throughput

0.881

High

278497

VAMP4
Vesicle-associated membrane protein 4

3

20

High-throughput

0.861

High

328664

VAMP5
Vesicle-associated membrane protein 5

3

20

High-throughput

0.855

High

908007

VAMP7
Vesicle-associated membrane protein 7

3

20

Small-scale

0.839

High

249851

STX10
Syntaxin-10

2

20

High-throughput

0.789

High

746198

STX2
Syntaxin-2

2

18

High-throughput

0.783

High

1100668

STX1A
Syntaxin-1A

2

18

High-throughput

0.783

High

933004

SNAA
Alpha-soluble NSF attachment protein

2

20

High-throughput

0.776

High

1100691

STXB6
Syntaxin-binding protein 6

3

5

High-throughput

0.765

High

1100706

SYTL4
Synaptotagmin-like protein 4

2

11

Small-scale

0.754

High

124048

SNP23
Synaptosomal-associated protein 23

10

20

Small-scale

0.754

High

1100684

CPLX4
Complexin-4

2

0

High-throughput

0.742

High

343369

SNP29
Synaptosomal-associated protein 29

5

20

Small-scale

0.715

High

1100700

SCFD1
Sec1 family domain-containing protein 1

1

20

High-throughput

0.691

High

1100676

STXB5
Syntaxin-binding protein 5

4

16

High-throughput

0.691

High

375480

RASK
GTPase KRas

4

20

High-throughput

0.676

High

1100662

SLMAP
Sarcolemmal membrane-associated protein

3

9

High-throughput

0.667

High

639127

SYT1
Synaptotagmin-1

1

8

Small-scale

0.647

High

954389

SNP25
Synaptosomal-associated protein 25

3

20

Small-scale

0.646

High

374564

RASH
GTPase HRas

3

20

High-throughput

0.640

High

821096

TXLNA
Alpha-taxilin

4

8

Small-scale

0.636

High

1100734

TBK1
Serine/threonine-protein kinase TBK1

4

10

High-throughput

0.630

High

163294

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

4

High-throughput

0.611

High

181319

PGRC2
Membrane-associated progesterone receptor component 2

2

3

High-throughput

0.606

High

549767

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

1

High-throughput

0.606

High

1100665

MSMO1
Methylsterol monooxygenase 1

2

1

High-throughput

0.606

High

1100673

F209A
Protein FAM209A

2

2

High-throughput

0.606

High

1100688

EMC5
ER membrane protein complex subunit 5

2

3

High-throughput

0.606

High

1100695

GP152
Probable G-protein coupled receptor 152

2

3

High-throughput

0.606

High

1100704

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.606

High

1100707

ZDH15
Palmitoyltransferase ZDHHC15

2

3

High-throughput

0.606

High

1100710

RMD3
Regulator of microtubule dynamics protein 3

2

2

High-throughput

0.606

High

1100726

SCN3B
Sodium channel regulatory subunit beta-3

2

5

High-throughput

0.606

High

60333

NBAS
NBAS subunit of NRZ tethering complex

2

2

High-throughput

0.601

High

1100690

T185A
Transmembrane protein 185A

2

0

High-throughput

0.585

High

373907

RASN
GTPase NRas

2

20

High-throughput

0.584

High

767427

RADI
Radixin

2

7

High-throughput

0.584

High

976241

RB11A
Ras-related protein Rab-11A

2

9

Small-scale

0.584

High

977976

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

1100661

FXYD3
FXYD domain-containing ion transport regulator 3

2

0

High-throughput

0.580

High

1100702

GSLG1
Golgi apparatus protein 1

2

0

High-throughput

0.576

High

1100685

STX12
Syntaxin-12

1

18

High-throughput

0.575

High

1100712

SNAG
Gamma-soluble NSF attachment protein

1

20

High-throughput

0.575

High

1100732

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

20

High-throughput

0.575

High

248981

EVI5
Ecotropic viral integration site 5 protein homolog

1

5

Small-scale

0.561

High

1100742

TBC30
TBC1 domain family member 30

1

5

Small-scale

0.561

High

139865

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

2

2

High-throughput

0.553

High

166910

MGST3
Glutathione S-transferase 3, mitochondrial

2

1

High-throughput

0.553

High

883413

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

2

High-throughput

0.553

High

1100659

AQP6
Aquaporin-6

2

17

High-throughput

0.553

High

1100675

MF14B
Hippocampus abundant transcript-like protein 1

2

5

High-throughput

0.553

High

1100689

JAGN1
Protein jagunal homolog 1

2

2

High-throughput

0.553

High

1100715

ELOV4
Very long chain fatty acid elongase 4

2

3

High-throughput

0.553

High

1100720

REEP4
Receptor expression-enhancing protein 4

2

1

High-throughput

0.553

High

1100724

TM14B
Transmembrane protein 14B

2

2

High-throughput

0.553

High

1100741

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

2

High-throughput

0.553

High

1100744

TMX2
Thioredoxin-related transmembrane protein 2

2

2

High-throughput

0.553

High

179888

BET1
BET1 homolog

1

20

High-throughput

0.536

High

302054

SEGN
Secretagogin

1

5

High-throughput

0.536

High

329923

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

2

High-throughput

0.536

High

332988

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

High-throughput

0.536

High

857096

NSF
Vesicle-fusing ATPase

1

16

High-throughput

0.536

High

911573

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.536

High

955120

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.536

High

1023015

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

1

3

High-throughput

0.536

High

1091920

SEC20
Vesicle transport protein SEC20

1

6

High-throughput

0.536

High

1100663

L2GL1
Lethal(2) giant larvae protein homolog 1

1

16

High-throughput

0.536

High

1100686

NRSN1
Neurensin-1

1

2

High-throughput

0.536

High

1100692

THOC2
THO complex subunit 2

1

3

High-throughput

0.536

High

1100729

USE1
Vesicle transport protein USE1

1

6

High-throughput

0.536

High

1100730

MYEF2
Myelin expression factor 2

1

1

High-throughput

0.536

High

1100731

STX18
Syntaxin-18

1

6

High-throughput

0.536

High

1100737

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

1

High-throughput

0.536

High

96848

E9PCW1
Golgi SNAP receptor complex member 1

1

10

High-throughput

0.514

High

274321

SIN3B
Paired amphipathic helix protein Sin3b

1

0

High-throughput

0.513

High

423770

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

438075

GLPB
Glycophorin-B

1

0

High-throughput

0.513

High

913314

MSH6
DNA mismatch repair protein Msh6

1

0

High-throughput

0.513

High

986392

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.513

High

1100658

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1100669

T132A
Transmembrane protein 132A

1

0

High-throughput

0.513

High

1100698

ZN526
Zinc finger protein 526

1

0

High-throughput

0.513

High

1100727

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.513

High

1100745

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

336099

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

11

Small-scale

0.512

High

507917

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.501

High

1100719

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.501

High

1100677

PI3R6
Phosphoinositide 3-kinase regulatory subunit 6

1

0

High-throughput

0.493

High

1100660

LAMB3
Laminin subunit beta-3

1

4

High-throughput

0.489

High

1100672

KRBX4
KRAB domain-containing protein 4

1

5

High-throughput

0.489

High

1100680

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.489

High

1100687

LSME2
Leucine-rich single-pass membrane protein 2

1

1

High-throughput

0.489

High

1100711

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

High-throughput

0.489

High

1100743

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

High-throughput

0.489

High

641947

CD9
CD9 antigen

1

11

High-throughput

0.484

High

385710

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

High-throughput

0.481

High

1100670

SOAT
Sodium-dependent organic anion transporter

1

5

High-throughput

0.481

High

211783

ZW10
Centromere/kinetochore protein zw10 homolog

1

2

High-throughput

0.479

High

466234

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

630508

RAB3B
Ras-related protein Rab-3B

1

11

Small-scale

0.479

High

631199

RAB5A
Ras-related protein Rab-5A

1

14

High-throughput

0.479

High

633913

ATP4A
Potassium-transporting ATPase alpha chain 1

1

5

Small-scale

0.479

High

810075

RL3
Large ribosomal subunit protein uL3

1

9

High-throughput

0.479

High

845624

MUC18
Cell surface glycoprotein MUC18

1

7

High-throughput

0.479

High

955926

RAB8A
Ras-related protein Rab-8A

1

8

Small-scale

0.479

High

988332

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1004517

RNF4
E3 ubiquitin-protein ligase RNF4

1

7

High-throughput

0.479

High

1015409

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041042

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1091806

TP4A2
Protein tyrosine phosphatase type IVA 2

1

5

Small-scale

0.479

High

1100671

MIDN
Midnolin

1

2

High-throughput

0.479

High

1100674

SNP47
Synaptosomal-associated protein 47

1

5

High-throughput

0.479

High

1100683

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1100693

EXOC6
Exocyst complex component 6

1

3

Small-scale

0.479

High

1100709

CK5P2
CDK5 regulatory subunit-associated protein 2

1

8

High-throughput

0.479

High

1100721

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

1100736

MYO5B
Unconventional myosin-Vb

1

1

Small-scale

0.479

High

408849

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

1066626

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.458

High

1100664

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.458

High

1100728

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

607585

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

7

High-throughput

0.445

High

923465

PTTG
Pituitary tumor-transforming gene 1 protein-interacting protein

1

3

High-throughput

0.445

High

1093505

TRDN
Triadin

1

7

High-throughput

0.445

High

1100679

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1100697

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

4

High-throughput

0.445

High

1100699

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

4

High-throughput

0.445

High

1100735

ZDHC8
Palmitoyltransferase ZDHHC8

1

4

High-throughput

0.445

High

1100746

PLXD1
Plexin-D1

1

3

High-throughput

0.445

High

482684

SPRC
SPARC

1

0

High-throughput

0.426

High

841716

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.426

High

1094324

CSN1
COP9 signalosome complex subunit 1

1

0

High-throughput

0.426

High

1100694

MIPT3
TRAF3-interacting protein 1

1

1

High-throughput

0.417

High

1100681

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

1100701

S39A7
Zinc transporter SLC39A7

1

10

High-throughput

0.407

High

1100714

OSBL8
Oxysterol-binding protein-related protein 8

1

8

High-throughput

0.407

High

1100739

COG5
Conserved oligomeric Golgi complex subunit 5

1

1

High-throughput

0.407

High

1100740

BCS1
Mitochondrial chaperone BCS1

1

5

High-throughput

0.407

High

275015

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

0

High-throughput

0.316

High

1100682

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.316

High

1100696

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1100717

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1100722

MANBL
Protein MANBAL

2

0

High-throughput

0.316

High

1100723

S35C2
Solute carrier family 35 member C2

2

0

High-throughput

0.316

High

1100678

FBX31
F-box only protein 31

1

0

High-throughput

0.279

Low

1100703

YIPF5
Protein YIPF5

1

0

High-throughput

0.279

Low

1100725

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.279

Low

1100733

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

895547

SERPH
Serpin H1

1

0

High-throughput

0.249

Low

1100705

CC049
Putative uncharacterized protein C3orf49

1

0

High-throughput

0.232

Low

1100708

CEP20
Centrosomal protein 20

1

0

High-throughput

0.232

Low

1100718

MFSD1
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025