HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	29103612, 37028429, 21145461, 25515538, 34478796, 17205132, 21946088, 21572988, 22268729
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol GO:0008283 - cell population proliferation GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 598
+	Mm
		1206618 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW8_MOUSE (1-598): 4.1e-112: 349: 75.08
+	Mm
		1257398 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW7_MOUSE (285-590): 4.32e-82: 273: 13.88
+	Hs
		1041133 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		1043100 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Hs
		1043454 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBXW8_HUMAN (1-598): 4.17e-132: 400: 96.17
+	Mm
		1112933 CUL1_MOUSE (1-776): 0: 912: 99.87		FBW1A_MOUSE (287-594): 6.07e-62: 217: 13.64
+	Hs
		1041292 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		1041266 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		903206 CUL1_HUMAN (1-776): 0: 911: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1041042 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW10_HUMAN (387-566): 8.88e-26: 114: 19.78
+	Hs
		245601 CUL4B_HUMAN (7-776): 0: 773: 29.90		TBL1X_HUMAN (20-421): 1.03e-58: 207: 9.62
+	Hs
		1043085 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		1043441 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5B_HUMAN (40-372): 8.51e-54: 188: 13.41
+	Hs
		792982 CUL4A_HUMAN (7-776): 0: 781: 30.41		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		1043114 CUL4A_HUMAN (7-776): 0: 781: 30.41		POC1B_HUMAN (428-590): 8.43e-39: 150: 15.39
+	Hs
		1043319 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		1043297 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		903208 CUL4A_HUMAN (7-776): 0: 781: 30.41		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		903209 CUL4B_HUMAN (7-776): 0: 773: 29.90		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		1016274 CUL4B_HUMAN (7-776): 0: 773: 29.90		TBL3_HUMAN (73-236): 2.09e-15: 81.8: 15.48