HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: UBE2F (Q969M7)
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
Gene: UBE2F

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19942853
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 185
+	Hs
		1041136 CUL1_HUMAN (1-776): 0: 911: 100.00		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Hs
		896072 CUL1_HUMAN (1-776): 0: 911: 100.00		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		849326 CUL4A_HUMAN (7-776): 0: 781: 30.41		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		895791 CUL4A_HUMAN (7-776): 0: 781: 30.41		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		1043149 CUL4A_HUMAN (7-776): 0: 781: 30.41		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Dm
		639393 CUL1_DROME (4-776): 0: 770: 61.98		UBCD1_DROME (32-184): 1.63e-73: 219: 32.03
+	Hs
		895792 CUL4B_HUMAN (7-776): 0: 773: 29.90		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		828994 CUL4B_HUMAN (7-776): 0: 773: 29.90		UBE2A_HUMAN (30-185): 1.58e-65: 199: 22.44
+	Hs
		849325 CUL3_HUMAN (9-776): 0: 748: 30.47		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		919724 CUL3_HUMAN (9-776): 0: 748: 30.47		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		1042304 CUL3_HUMAN (9-776): 0: 748: 30.47		UB2E2_HUMAN (9-184): 1.68e-71: 216: 27.27
+	Hs
		851812 CUL3_HUMAN (9-776): 0: 748: 30.47		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		1042223 CUL3_HUMAN (9-776): 0: 748: 30.47		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	At
		1228143 CUL4_ARATH (6-776): 0: 723: 28.92		COP10_ARATH (13-185): 7.31e-66: 201: 26.01
+	Hs
		896075 CUL4A_HUMAN (7-776): 0: 781: 30.41		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Hs
		896076 CUL4B_HUMAN (7-776): 0: 773: 29.90		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Dm
		1097207 CUL1_DROME (4-776): 0: 770: 61.98		UBC2M_DROME (9-181): 7.12e-34: 120: 38.73
+	Hs
		896074 CUL3_HUMAN (9-776): 0: 748: 30.47		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51
+	Dm
		1213851 Q8IP45_DROME (10-776): 0: 729: 30.03		UBC2M_DROME (9-181): 7.12e-34: 120: 38.73
+	At
		1277342 CUL1_ARATH (10-776): 0: 722: 30.29		RCE1_ARATH (17-162): 2.13e-28: 105: 38.78