Protein: STAM1
Signal transducing adapter molecule 1 (STAM-1)

Gene: STAM1, STAM
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q92783

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0016236 - macroautophagy
GO:0031901 - early endosome membrane
GO:0033565 - ESCRT-0 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

169681

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

17

18

Small-scale

0.989

High

508369

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

15

20

Small-scale

0.983

High

882541

ARRB1
Beta-arrestin-1

2

2

Small-scale

0.834

High

296540

STAM2
Signal transducing adapter molecule 2

2

19

High-throughput

0.811

High

1368289

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.806

High

340658

STABP
STAM-binding protein

12

3

Small-scale

0.762

High

412369

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

1107985

SQSTM
Sequestosome-1

2

7

High-throughput

0.754

High

253370

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.724

High

828235

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

4

9

Small-scale

0.694

High

467700

CEL2A
Chymotrypsin-like elastase family member 2A

1

4

High-throughput

0.691

High

710407

EPHA2
Ephrin type-A receptor 2

2

20

High-throughput

0.675

High

1094314

LCP2
Lymphocyte cytosolic protein 2

1

16

Small-scale

0.647

High

1368310

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

11

Small-scale

0.647

High

1026158

CLH1
Clathrin heavy chain 1

3

19

Small-scale

0.646

High

1111955

SNX1
Sorting nexin-1

2

10

High-throughput

0.628

High

1104797

SNTA1
Alpha-1-syntrophin

1

10

Small-scale

0.618

High

541620

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

593460

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.618

High

710739

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.618

High

911941

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

942792

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

13

High-throughput

0.618

High

987143

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

1295517

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

1368297

TOLIP
Toll-interacting protein

1

10

High-throughput

0.618

High

1368309

UBQL2
Ubiquilin-2

1

15

High-throughput

0.618

High

1368311

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1246138

TRAF7
E3 ubiquitin-protein ligase TRAF7

2

0

High-throughput

0.602

High

650332

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

944018

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.590

High

323898

SC31A
Protein transport protein Sec31A

2

5

Small-scale

0.584

High

1368300

PTN23
Tyrosine-protein phosphatase non-receptor type 23

2

20

Small-scale

0.584

High

1368283

PMEPA
Protein TMEPAI

1

1

Small-scale

0.573

High

1368301

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.555

High

641227

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.553

High

648616

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

931879

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

1157019

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.553

High

1368285

ARRD3
Arrestin domain-containing protein 3

1

8

Small-scale

0.553

High

274689

DNJB6
DnaJ homolog subfamily B member 6

1

6

High-throughput

0.536

High

347218

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

537632

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.536

High

652377

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

679226

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.536

High

730119

1433B
14-3-3 protein beta/alpha

1

13

High-throughput

0.536

High

925671

IST1
IST1 homolog

1

2

High-throughput

0.536

High

959377

RAP1B
Ras-related protein Rap-1b

1

12

High-throughput

0.536

High

994318

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.536

High

1136046

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1365204

HS105
Heat shock protein 105 kDa

1

11

High-throughput

0.536

High

1368288

MB12A
Multivesicular body subunit 12A

1

5

High-throughput

0.536

High

1368292

TS101
Tumor susceptibility gene 101 protein

1

13

High-throughput

0.536

High

1368317

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.536

High

238727

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

1

Small-scale

0.523

High

374825

RASH
GTPase HRas

1

12

High-throughput

0.515

High

702488

CLAT
Choline O-acetyltransferase

1

2

High-throughput

0.515

High

1105898

LSAMP
Limbic system-associated membrane protein

1

3

High-throughput

0.515

High

271555

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

1368293

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.513

High

1368316

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

967891

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.508

High

132197

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.501

High

1098820

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

9

Small-scale

0.501

High

1361988

RFFL
E3 ubiquitin-protein ligase rififylin

1

5

High-throughput

0.501

High

1368282

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1368290

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

4

High-throughput

0.501

High

1368295

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

1368296

TRI55
Tripartite motif-containing protein 55

1

18

High-throughput

0.501

High

1368315

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

8

High-throughput

0.501

High

65949

LIRA5
Leukocyte immunoglobulin-like receptor subfamily A member 5

1

6

High-throughput

0.489

High

215620

EMC8
ER membrane protein complex subunit 8

1

2

High-throughput

0.489

High

1337618

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

1368305

HPBP1
Hsp70-binding protein 1

1

1

High-throughput

0.489

High

1368313

EMC9
ER membrane protein complex subunit 9

1

2

High-throughput

0.489

High

1368318

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

786757

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

Small-scale

0.481

High

791594

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

226159

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

321984

NFAT5
Nuclear factor of activated T-cells 5

1

5

Small-scale

0.479

High

338522

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.479

High

562282

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

604139

CXA1
Gap junction alpha-1 protein

1

9

High-throughput

0.479

High

700700

PSA5
Proteasome subunit alpha type-5

1

2

Small-scale

0.479

High

714314

PML
Protein PML

1

3

High-throughput

0.479

High

831163

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

920153

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.479

High

922476

CLH2
Clathrin heavy chain 2

1

19

Small-scale

0.479

High

938257

SEC13
Protein SEC13 homolog

1

1

Small-scale

0.479

High

939957

TPTE
Putative tyrosine-protein phosphatase TPTE

1

4

High-throughput

0.479

High

986610

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

1031480

IFM3
Interferon-induced transmembrane protein 3

1

10

High-throughput

0.479

High

1041211

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

1095737

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

17

High-throughput

0.479

High

1270931

RHOU
Rho-related GTP-binding protein RhoU

1

12

High-throughput

0.479

High

1289504

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1350937

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

4

Small-scale

0.479

High

1353115

FBF1
Fas-binding factor 1

1

11

High-throughput

0.479

High

1356968

PDC6I
Programmed cell death 6-interacting protein

1

20

Small-scale

0.479

High

1366933

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

1368286

OPTN
Optineurin

1

9

High-throughput

0.479

High

1368291

SORT
Sortilin

1

7

Small-scale

0.479

High

1368302

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.479

High

1368303

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.479

High

1368306

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

1368307

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.479

High

1368308

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1368312

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

1368298

MED28
Mediator of RNA polymerase II transcription subunit 28

1

1

Small-scale

0.470

High

1368294

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.470

High

1368314

RNF11
RING finger protein 11

1

8

High-throughput

0.470

High

821749

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

Small-scale

0.458

High

369195

OAS1
2'-5'-oligoadenylate synthase 1

1

1

High-throughput

0.445

High

530160

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

1015651

RHOG
Rho-related GTP-binding protein RhoG

1

3

Small-scale

0.445

High

106387

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

180003

BET1
BET1 homolog

1

7

High-throughput

0.437

High

218574

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.437

High

326970

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.437

High

327393

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.437

High

488833

FURIN
Furin

1

3

High-throughput

0.437

High

560470

IFM1
Interferon-induced transmembrane protein 1

1

10

High-throughput

0.437

High

643004

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

774532

BASI
Basigin

1

7

High-throughput

0.437

High

855282

GPR4
G-prodeshotein coupled receptor 4

1

5

Small-scale

0.437

High

1229020

RNF43
E3 ubiquitin-protein ligase RNF43

1

12

High-throughput

0.437

High

1245108

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.437

High

1254895

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

1293102

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

1322928

CXD3
Gap junction delta-3 protein

1

9

High-throughput

0.437

High

1368281

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

10

High-throughput

0.437

High

1368284

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.437

High

117803

M0QZK6
Multivesicular body subunit 12A

1

5

High-throughput

0.407

High

330258

VENTX
Homeobox protein VENTX

1

7

High-throughput

0.407

High

1244893

NCEH1
Neutral cholesterol ester hydrolase 1

2

0

High-throughput

0.328

High

1258655

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

1368299

GO45
Golgin-45

1

0

High-throughput

0.279

Low

1368304

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.279

Low

1339823

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

High-throughput

0.261

Low

1226484

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1368287

HAVR1
Hepatitis A virus cellular receptor 1

1

0

Small-scale

0.249

Low

1193224

SPDE7
Putative speedy protein E7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025