HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: SENP8 (Q96LD8)
Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)
Gene: SENP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	20190741, 23408908
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 212
+	Hs
		1041201 CUL1_HUMAN (1-776): 0: 911: 100.00		SENP3_HUMAN (6-192): 8.67e-59: 195: 18.04
+	Hs
		1043166 CUL4A_HUMAN (7-776): 0: 781: 30.41		SENP8_HUMAN (1-212): 1.66e-74: 225: 100.00
+	Hs
		1041437 CUL2_HUMAN (13-776): 0: 720: 35.98		SENP8_HUMAN (1-212): 1.66e-74: 225: 100.00
+	Hs
		1042533 CUL3_HUMAN (9-776): 0: 748: 30.47		SENP3_HUMAN (6-192): 8.67e-59: 195: 18.04
+	Sp
		141975 CUL1_SCHPO (1-776): 0: 733: 40.92		NEP2_SCHPO (3-209): 1.12e-52: 175: 26.51
+	Sp
		142908 CUL1_SCHPO (1-776): 0: 733: 40.92		NESP1_SCHPO (3-212): 3.76e-46: 159: 22.42
+	Sp
		195008 CUL3_SCHPO (5-776): 0: 635: 26.43		NESP1_SCHPO (3-212): 3.76e-46: 159: 22.42