Protein: MRCKA
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)

Gene: MRCKA, CDC42BPA
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q5VT25

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955277

CDC42
Cell division control protein 42 homolog

5

20

Small-scale

0.929

High

1217577

MRCKB
Serine/threonine-protein kinase MRCK beta

3

19

High-throughput

0.864

High

966445

1433G
14-3-3 protein gamma

3

20

High-throughput

0.839

High

1049396

1433F
14-3-3 protein eta

3

20

High-throughput

0.839

High

1217526

MRCKA
Serine/threonine-protein kinase MRCK alpha

2

17

Small-scale

0.833

High

971623

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.789

High

990331

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.789

High

1217569

INKA2
PAK4-inhibitor INKA2

3

1

High-throughput

0.770

High

373982

RASN
GTPase NRas

2

20

High-throughput

0.754

High

375598

RASK
GTPase KRas

2

20

High-throughput

0.754

High

601324

RHOQ
Rho-related GTP-binding protein RhoQ

2

20

Small-scale

0.754

High

978071

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

210395

MTLR
Motilin receptor

1

1

High-throughput

0.691

High

669133

ARBK1
Beta-adrenergic receptor kinase 1

1

16

High-throughput

0.691

High

937476

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

14

High-throughput

0.691

High

995082

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.691

High

1217578

RBM8A
RNA-binding protein 8A

1

9

High-throughput

0.691

High

1217540

KCD17
BTB/POZ domain-containing protein KCTD17

4

11

High-throughput

0.691

High

776972

PPM1A
Protein phosphatase 1A

1

4

Small-scale

0.647

High

464986

SP1
Transcription factor Sp1

1

5

High-throughput

0.646

High

126642

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

136097

PLK4
Serine/threonine-protein kinase PLK4

1

15

Small-scale

0.618

High

374669

RASH
GTPase HRas

1

20

High-throughput

0.618

High

400976

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

High-throughput

0.618

High

412071

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.618

High

440112

LCK
Tyrosine-protein kinase Lck

1

15

High-throughput

0.618

High

463575

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.618

High

573515

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

581101

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

691104

1433T
14-3-3 protein theta

1

20

High-throughput

0.618

High

705707

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

2

High-throughput

0.618

High

729924

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

730658

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

897857

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.618

High

901298

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.618

High

910090

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

936354

AFAD
Afadin

1

16

High-throughput

0.618

High

953499

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

956337

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

962148

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

962764

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

976324

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

988432

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1004086

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.618

High

1015512

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1144949

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

1151729

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1217530

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

1217532

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1217545

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1217546

ARHG2
Rho guanine nucleotide exchange factor 2

1

11

High-throughput

0.618

High

1217558

DNJC7
DnaJ homolog subfamily C member 7

1

10

High-throughput

0.618

High

1217562

DNJC5
DnaJ homolog subfamily C member 5

1

8

High-throughput

0.618

High

1217563

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1217564

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1217566

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1217574

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.618

High

1217576

ALK
ALK tyrosine kinase receptor

1

12

High-throughput

0.618

High

1217534

LUR1L
Leucine rich adaptor protein 1-like

3

8

High-throughput

0.609

High

1217551

F167A
Protein FAM167A

3

2

High-throughput

0.604

High

1217541

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.601

High

1217553

LURA1
Leucine rich adaptor protein 1

2

8

High-throughput

0.601

High

975081

ARF6
ADP-ribosylation factor 6

2

6

High-throughput

0.584

High

1217531

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.578

High

1217542

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.578

High

618698

ML12A
Myosin regulatory light chain 12A

1

14

Small-scale

0.575

High

1099110

SRSF5
Serine/arginine-rich splicing factor 5

1

13

High-throughput

0.575

High

553356

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

4

High-throughput

0.574

High

396296

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

341079

DIRA3
GTP-binding protein Di-Ras3

1

10

High-throughput

0.553

High

472808

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.553

High

845676

MUC18
Cell surface glycoprotein MUC18

1

9

High-throughput

0.553

High

1217529

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.553

High

1217552

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1217560

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.553

High

639752

TAF1
Transcription initiation factor TFIID subunit 1

1

13

High-throughput

0.541

High

436896

K1C18
Keratin, type I cytoskeletal 18

1

4

High-throughput

0.536

High

859860

RL28
Large ribosomal subunit protein eL28

1

2

High-throughput

0.536

High

945803

EPIPL
Epiplakin

1

11

High-throughput

0.536

High

975740

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.536

High

1109803

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.536

High

1144023

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1217535

SKA3
Spindle and kinetochore-associated protein 3

1

1

High-throughput

0.536

High

1217555

KI20B
Kinesin-like protein KIF20B

1

9

High-throughput

0.536

High

1217571

GPC5B
G-protein coupled receptor family C group 5 member B

1

5

High-throughput

0.536

High

333350

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

1027519

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.515

High

549609

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

642562

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1217533

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1217547

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

190384

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

451398

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.489

High

1053370

CTSL2
CTD small phosphatase-like protein 2

1

4

High-throughput

0.489

High

129169

MEN1
Menin

1

1

High-throughput

0.479

High

189621

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

226066

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

299236

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

520115

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

540492

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

547017

GNAT1
Guanine nucleotide-binding protein G(t) subunit alpha-1

1

3

High-throughput

0.479

High

562116

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

566397

K2C5
Keratin, type II cytoskeletal 5

1

1

High-throughput

0.479

High

582836

EZRI
Ezrin

1

9

High-throughput

0.479

High

604027

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

692995

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

715624

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

872421

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

904824

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

941791

ARL4C
ADP-ribosylation factor-like protein 4C

1

13

High-throughput

0.479

High

970642

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

973468

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.479

High

1087145

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1159685

OCLN
Occludin

1

2

High-throughput

0.479

High

1217528

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1217538

ARL14
ADP-ribosylation factor-like protein 14

1

8

High-throughput

0.479

High

1217544

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1217548

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

1217554

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1217556

RUFY1
RUN and FYVE domain-containing protein 1

1

19

High-throughput

0.479

High

1217557

TBX5
T-box transcription factor TBX5

1

1

High-throughput

0.479

High

1217567

E41LA
Band 4.1-like protein 4A

1

9

High-throughput

0.479

High

1217570

ARL15
ADP-ribosylation factor-like protein 15

1

11

High-throughput

0.479

High

1217575

SEPT9
Septin-9

1

2

High-throughput

0.479

High

1217579

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

3

High-throughput

0.479

High

596148

H12
Histone H1.2

1

6

High-throughput

0.470

High

327308

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

1023552

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1217543

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1217561

IN80B
INO80 complex subunit B

1

0

High-throughput

0.458

High

1056785

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

1217568

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

324149

CE152
Centrosomal protein of 152 kDa

1

7

High-throughput

0.445

High

1217527

CP135
Centrosomal protein of 135 kDa

1

15

High-throughput

0.445

High

1217537

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

372263

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

642922

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

1041111

CAV1
Caveolin-1

1

2

High-throughput

0.437

High

1217536

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1217549

VP33A
Vacuolar protein sorting-associated protein 33A

1

3

High-throughput

0.437

High

1217550

FA89A
Protein FAM89A

1

1

High-throughput

0.437

High

616760

SDC1
Syndecan-1

1

0

High-throughput

0.426

High

1217573

SL9A2
Sodium/hydrogen exchanger 2

1

4

High-throughput

0.407

High

1217565

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

139893

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

657598

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

1217572

SEP10
Septin-10

1

0

High-throughput

0.249

Low

1217539

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.232

Low

1217559

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025