HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBX44 (Q9H4M3)
F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)
Gene: FBXO44

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	26186194, 25970626, 28514442, 33961781, 17215248, 18203720, 21640084, 29103612, 37028429, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 255
+	Hs
		1041217 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX6_HUMAN (2-254): 3.06e-140: 397: 75.10
+	Hs
		1041259 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX2_HUMAN (16-252): 2.8e-115: 333: 48.33
+	Mm
		1193600 CUL1_MOUSE (1-776): 0: 912: 99.87		FBX2_MOUSE (16-252): 3.57e-112: 326: 48.95
+	Hs
		1041142 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX17_HUMAN (6-254): 1.77e-109: 318: 33.71
+	Hs
		1041102 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX27_HUMAN (19-254): 1.26e-105: 308: 39.36
+	Hs
		1043220 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBX44_HUMAN (1-255): 3.62e-141: 397: 100.00
+	Hs
		1043585 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBX44_HUMAN (1-255): 3.62e-141: 397: 100.00
+	Hs
		1274013 CUL5_HUMAN (2-776): 0: 622: 28.85		FBX17_HUMAN (6-254): 1.77e-109: 318: 33.71