HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000922 - spindle pole GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0072686 - mitotic spindle
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1278
+	Hs
		1042974 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCTN1_HUMAN (1-1278): 1.48e-90: 322: 100.00
+	Hs
		1042610 CUL3_HUMAN (1-768): 0: 951: 100.00		KI13B_HUMAN (14-145): 4.98e-32: 138: 32.85
+	Hs
		725157 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		675166 CUL3_HUMAN (1-768): 0: 951: 100.00		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Hs
		724816 CUL3_HUMAN (1-768): 0: 951: 100.00		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		551697 CUL3_HUMAN (1-768): 0: 951: 100.00		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Hs
		725158 CUL4A_HUMAN (10-768): 0: 791: 38.32		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		725156 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		724815 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		502913 CUL1_HUMAN (18-768): 0: 707: 30.57		MYH3_HUMAN (830-1278): 8.46e-13: 75.6: 10.11
+	Hs
		551696 CUL2_HUMAN (30-768): 0: 672: 26.17		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64