Protein: PAF1
RNA polymerase II-associated protein 1 (Protein PAF1)

Gene: PAF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P38351

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000791 - euchromatin
GO:0000993 - RNA polymerase II complex binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798610

CTR9
RNA polymerase-associated protein CTR9

15

6

Small-scale

0.985

High

798594

LEO1
RNA polymerase-associated protein LEO1

11

8

Small-scale

0.977

High

470517

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

1

Small-scale

0.768

High

798622

CDC73
Cell division control protein 73

16

3

Small-scale

0.762

High

798604

RTF1
RNA polymerase-associated protein RTF1

14

2

Small-scale

0.761

High

739616

SPT16
FACT complex subunit SPT16

10

1

Small-scale

0.755

High

798593

PAF1
RNA polymerase II-associated protein 1

2

0

Small-scale

0.736

High

401987

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

2

Small-scale

0.704

High

594346

RPB3
DNA-directed RNA polymerase II subunit RPB3

6

0

Small-scale

0.695

High

798617

POB3
FACT complex subunit POB3

7

2

Small-scale

0.679

High

694536

SPT5
Transcription elongation factor SPT5

2

2

Small-scale

0.621

High

647094

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.618

High

585920

CSK21
Casein kinase II subunit alpha

2

2

Small-scale

0.611

High

438532

UBC2
Ubiquitin-conjugating enzyme E2 2

2

1

Small-scale

0.595

High

798611

SEN1
Helicase SEN1

2

1

Small-scale

0.588

High

798613

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

Small-scale

0.573

High

364500

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.561

High

605893

HPR1
THO complex subunit HPR1

2

0

Small-scale

0.559

High

670640

SIS1
Protein SIS1

2

0

High-throughput

0.559

High

740792

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.559

High

798600

T2FB
Transcription initiation factor IIF subunit beta

2

0

Small-scale

0.547

High

793414

ATR
Serine/threonine-protein kinase MEC1

1

0

Small-scale

0.537

High

798607

ELOA1
Elongin-A

1

0

Small-scale

0.537

High

622938

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.515

High

750930

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

Small-scale

0.515

High

454570

TFS2
Transcription elongation factor S-II

1

1

Small-scale

0.501

High

744292

CHD1
Chromo domain-containing protein 1

1

3

Small-scale

0.501

High

798609

H3
Histone H3

1

2

Small-scale

0.501

High

798623

BRE1
E3 ubiquitin-protein ligase BRE1

1

2

Small-scale

0.501

High

661163

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

706959

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

708725

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

779217

CENPA
Histone H3-like centromeric protein CSE4

1

2

High-throughput

0.479

High

798596

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

1

Small-scale

0.479

High

798599

RAD26
DNA repair and recombination protein RAD26

1

3

Small-scale

0.479

High

798605

INO80
Chromatin-remodeling ATPase INO80

1

3

Small-scale

0.479

High

436395

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

624905

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.458

High

645160

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.458

High

677368

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

679622

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

726210

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

Small-scale

0.458

High

734951

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

735782

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.458

High

737839

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

747824

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

757481

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

Small-scale

0.458

High

798598

PHM8
Phosphate metabolism protein 8

1

0

High-throughput

0.458

High

798602

CLA4
Serine/threonine-protein kinase CLA4

1

0

Small-scale

0.458

High

798608

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

798612

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.458

High

798614

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

High-throughput

0.458

High

798615

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

798618

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

798619

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.458

High

798621

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

798625

NCBP2
Nuclear cap-binding protein subunit 2

1

0

Small-scale

0.458

High

798627

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

798628

CMR3
Zinc finger protein CRM3

1

0

High-throughput

0.458

High

798629

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

798630

YO342
Uncharacterized protein YOR342C

1

0

High-throughput

0.458

High

523788

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526561

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

741481

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

721606

RENT1
ATP-dependent helicase NAM7

1

1

Small-scale

0.437

High

798616

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.437

High

544697

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

739351

ZUO1
Zuotin

1

0

High-throughput

0.426

High

798595

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

0

High-throughput

0.282

High

798597

RBG1
Ribosome-interacting GTPase 1

1

0

High-throughput

0.269

Low

798603

BRO1
Vacuolar-sorting protein BRO1

1

0

High-throughput

0.269

Low

798631

AYT1
Trichothecene 3-O-acetyltransferase

1

0

High-throughput

0.269

Low

798632

GLO4
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.269

Low

531471

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.249

Low

579305

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

782604

OMA1
Mitochondrial metalloendopeptidase OMA1

1

0

High-throughput

0.249

Low

789800

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.249

Low

798601

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

798606

SUN4
Probable secreted beta-glucosidase SUN4

1

0

High-throughput

0.249

Low

798620

YPQ2
Vacuolar arginine/histidine antiporter YPQ2

1

0

High-throughput

0.249

Low

798624

CRT10
Protein CRT10

1

0

Small-scale

0.249

Low

798626

PGC1
Phosphatidylglycerol phospholipase C

1

0

High-throughput

0.249

Low

626712

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

752200

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025