Protein: SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component SET1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1)

Gene: SET1
Organism: Saccharomyces cerevisiae S288C
Interactions: 97
UniProt ID: P38827

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

781134

SWD2
COMPASS component SWD2

17

20

Small-scale

0.988

High

805544

SWD1
COMPASS component SWD1

16

20

Small-scale

0.987

High

793854

SWD3
COMPASS component SWD3

15

20

Small-scale

0.984

High

805564

H3
Histone H3

7

20

Small-scale

0.958

High

401994

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

13

Small-scale

0.821

High

805549

BRE2
COMPASS component BRE2

23

12

Small-scale

0.768

High

805573

SPP1
COMPASS component SPP1

18

17

Small-scale

0.767

High

805538

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

2

19

Small-scale

0.737

High

805574

SDC1
COMPASS component SDC1

13

0

Small-scale

0.729

High

798403

SHG1
COMPASS component SHG1

13

0

Small-scale

0.729

High

594358

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

3

Small-scale

0.640

High

796836

SIF2
SIR4-interacting protein SIF2

1

20

Small-scale

0.618

High

805569

MEC3
DNA damage checkpoint control protein MEC3

2

0

Small-scale

0.617

High

805566

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

Small-scale

0.586

High

805565

CTR9
RNA polymerase-associated protein CTR9

2

20

Small-scale

0.584

High

805556

CLA4
Serine/threonine-protein kinase CLA4

1

2

Small-scale

0.578

High

805559

CDH1
APC/C activator protein CDH1

1

20

Small-scale

0.578

High

381513

H2B2
Histone H2B.2

1

20

High-throughput

0.575

High

382090

H4
Histone H4

1

11

High-throughput

0.575

High

805567

CDC14
Tyrosine-protein phosphatase CDC14

2

8

Small-scale

0.571

High

544805

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

689027

RL16A
Large ribosomal subunit protein uL13A

1

2

Small-scale

0.536

High

805583

HAT1
Histone acetyltransferase type B catalytic subunit

1

2

High-throughput

0.515

High

805562

FPK1
Flippase kinase 1

1

4

Small-scale

0.501

High

801822

KSP1
Serine/threonine-protein kinase KSP1

1

3

High-throughput

0.500

High

410120

RL25
Large ribosomal subunit protein uL23

1

6

High-throughput

0.479

High

433630

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

455052

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

575940

CYPH
Peptidyl-prolyl cis-trans isomerase

1

6

Small-scale

0.479

High

585489

KCY
Uridylate kinase

1

3

High-throughput

0.479

High

585930

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.479

High

642041

DPOE
DNA polymerase epsilon catalytic subunit A

1

2

Small-scale

0.479

High

672764

SNT1
Probable DNA-binding protein SNT1

1

13

Small-scale

0.479

High

707043

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

778320

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

792796

ANM1
Protein arginine N-methyltransferase 1

1

5

High-throughput

0.479

High

798596

PAF1
RNA polymerase II-associated protein 1

1

1

Small-scale

0.479

High

800249

LEO1
RNA polymerase-associated protein LEO1

1

1

Small-scale

0.479

High

805546

HOS4
Protein HOS4

1

4

Small-scale

0.479

High

805558

HOS2
Probable histone deacetylase HOS2

1

20

Small-scale

0.479

High

805561

HST1
NAD-dependent protein deacetylase HST1

1

10

Small-scale

0.479

High

805563

ORC1
Origin recognition complex subunit 1

1

3

High-throughput

0.479

High

805571

IMA1
Importin subunit alpha

1

5

Small-scale

0.479

High

805575

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

805577

IMB1
Importin subunit beta-1

1

5

Small-scale

0.479

High

805578

CDC73
Cell division control protein 73

1

3

Small-scale

0.479

High

805581

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.479

High

805584

SKM1
Serine/threonine-protein kinase SKM1

1

8

Small-scale

0.479

High

805552

SUM1
Suppressor of mar1-1 protein

1

0

Small-scale

0.458

High

805557

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.458

High

805576

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.458

High

805582

RFM1
Repression factor of MSEs protein 1

1

0

Small-scale

0.458

High

453588

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.457

High

510469

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.457

High

526645

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

712983

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.445

High

743091

STH1
Nuclear protein STH1/NPS1

1

20

High-throughput

0.445

High

794175

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

High-throughput

0.445

High

805545

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

805550

RSC8
Chromatin structure-remodeling complex protein RSC8

1

5

High-throughput

0.445

High

805554

SMC3
Structural maintenance of chromosomes protein 3

1

7

High-throughput

0.445

High

805579

BRE1
E3 ubiquitin-protein ligase BRE1

1

11

High-throughput

0.445

High

149752

RS9A
Small ribosomal subunit protein uS4A

1

5

High-throughput

0.437

High

365041

KPYK1
Pyruvate kinase 1

1

2

Small-scale

0.437

High

383691

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

435953

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

503033

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

504201

RL31A
Large ribosomal subunit protein eL31A

1

6

High-throughput

0.437

High

511793

RS24A
Small ribosomal subunit protein eS24A

1

1

Small-scale

0.437

High

512429

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.437

High

514629

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

531324

METK1
S-adenosylmethionine synthase 1

1

2

Small-scale

0.437

High

553989

TCPA
T-complex protein 1 subunit alpha

1

17

Small-scale

0.437

High

790198

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

Small-scale

0.437

High

802160

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

805540

TCPB
T-complex protein 1 subunit beta

1

19

Small-scale

0.437

High

805541

TCPG
T-complex protein 1 subunit gamma

1

20

Small-scale

0.437

High

805542

TCPD
T-complex protein 1 subunit delta

1

20

Small-scale

0.437

High

805543

TCPZ
T-complex protein 1 subunit zeta

1

20

Small-scale

0.437

High

805547

SER33
D-3-phosphoglycerate dehydrogenase 2

1

3

Small-scale

0.437

High

805548

TCPH
T-complex protein 1 subunit eta

1

20

Small-scale

0.437

High

805555

TCPQ
T-complex protein 1 subunit theta

1

20

Small-scale

0.437

High

744530

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.426

High

805553

NET1
Nucleolar protein NET1

1

0

High-throughput

0.426

High

805570

LGE1
Transcriptional regulatory protein LGE1

1

0

High-throughput

0.426

High

671469

BUD5
Bud site selection protein 5

1

1

High-throughput

0.417

High

805568

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.417

High

394538

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

805539

KOG1
Target of rapamycin complex 1 subunit KOG1

1

14

High-throughput

0.407

High

805560

DAM1
DASH complex subunit DAM1

1

0

Small-scale

0.269

Low

805551

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

805580

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.261

Low

360979

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

671326

CANB
Calcineurin subunit B

1

0

High-throughput

0.238

Low

805585

VPS5
Vacuolar protein sorting-associated protein 5

1

0

High-throughput

0.238

Low

805572

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025