HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: ECM29 (Q5VYK3)
Proteasome adapter and scaffold protein ECM29 (Ecm29 proteasome adapter and scaffold) (Proteasome-associated protein ECM29 homolog)
Gene: ECPAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~Vac14_Fab1_bd
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 1845
+	Hs
		1043050 CUL4A_HUMAN (10-768): 0: 791: 38.32		ECM29_HUMAN (1-1845): 0: 1279: 100.00
+	Hs
		268709 CUL3_HUMAN (1-768): 0: 951: 100.00		SF3B1_HUMAN (914-1694): 4.33e-90: 324: 12.53
+	Hs
		1041947 CUL3_HUMAN (1-768): 0: 951: 100.00		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Hs
		127264 CUL3_HUMAN (1-768): 0: 951: 100.00		IPO5_HUMAN (260-1256): 3.58e-16: 87.1: 10.19
+	Hs
		268708 CUL1_HUMAN (18-768): 0: 707: 30.57		SF3B1_HUMAN (914-1694): 4.33e-90: 324: 12.53
+	Hs
		672116 CUL3_HUMAN (1-768): 0: 951: 100.00		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Hs
		1042209 CUL3_HUMAN (1-768): 0: 951: 100.00		TNPO1_HUMAN (410-1097): 3.23e-13: 77.1: 12.20
+	Hs
		1042184 CUL3_HUMAN (1-768): 0: 951: 100.00		GCN1_HUMAN (34-1064): 1.01e-12: 75.9: 11.52
+	Hs
		155572 CUL3_HUMAN (1-768): 0: 951: 100.00		TNPO2_HUMAN (412-1129): 5.49e-09: 63.2: 10.00
+	Hs
		1042969 CUL4A_HUMAN (10-768): 0: 791: 38.32		CKAP5_HUMAN (817-1838): 1.5e-38: 161: 11.55
+	Hs
		1043084 CUL4A_HUMAN (10-768): 0: 791: 38.32		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Hs
		1043440 CUL4B_HUMAN (5-768): 0: 779: 36.77		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Hs
		672117 CUL4A_HUMAN (10-768): 0: 791: 38.32		2AAA_HUMAN (1242-1703): 6.29e-14: 79.2: 13.42
+	Mm
		1169688 CUL1_MOUSE (17-768): 0: 709: 30.53		CAND1_MOUSE (282-1301): 3.43e-34: 146: 12.77
+	Hs
		1041074 CUL1_HUMAN (18-768): 0: 707: 30.57		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Hs
		1041383 CUL2_HUMAN (30-768): 0: 672: 26.17		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77
+	Hs
		1202033 CUL5_HUMAN (25-768): 0: 597: 23.77		CAND1_HUMAN (282-1301): 2.08e-34: 146: 12.77