Protein: NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)

Gene: NR4A1
Organism: Homo sapiens
Interactions: 228
UniProt ID: P22736

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001530 - lipopolysaccharide binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625761

RXRA
Retinoic acid receptor RXR-alpha

3

20

Small-scale

0.856

High

652460

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.792

High

652521

NCOA1
Nuclear receptor coactivator 1

2

20

Small-scale

0.768

High

652456

CTNB1
Catenin beta-1

2

20

Small-scale

0.754

High

522045

BCL2
Apoptosis regulator Bcl-2

3

8

Small-scale

0.692

High

403826

GCR
Glucocorticoid receptor

1

20

High-throughput

0.656

High

468077

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.656

High

652566

PGBD1
PiggyBac transposable element-derived protein 1

2

7

High-throughput

0.654

High

652471

RXRG
Retinoic acid receptor RXR-gamma

1

20

Small-scale

0.647

High

652611

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.647

High

413195

P53
Cellular tumor antigen p53

2

7

Small-scale

0.639

High

652528

MIDN
Midnolin

3

0

High-throughput

0.638

High

652610

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.631

High

652533

ACD11
Acyl-CoA dehydrogenase family member 11

2

8

High-throughput

0.628

High

652481

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

20

High-throughput

0.628

High

253583

IMA7
Importin subunit alpha-7

1

9

Small-scale

0.618

High

573329

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

652447

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

19

Small-scale

0.618

High

652478

IMA5
Importin subunit alpha-5

1

9

Small-scale

0.618

High

652519

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.618

High

652470

MK08
Mitogen-activated protein kinase 8

2

18

Small-scale

0.602

High

652497

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.602

High

652503

PRDX4
Peroxiredoxin-4

2

8

High-throughput

0.595

High

652583

ROBO2
Roundabout homolog 2

1

5

High-throughput

0.587

High

652494

SMAD3
Mothers against decapentaplegic homolog 3

2

12

Small-scale

0.586

High

652523

MK14
Mitogen-activated protein kinase 14

1

18

Small-scale

0.586

High

172476

XPO1
Exportin-1

2

10

Small-scale

0.584

High

258235

TRI13
E3 ubiquitin-protein ligase TRIM13

2

15

Small-scale

0.584

High

652510

SQSTM
Sequestosome-1

2

9

Small-scale

0.584

High

652517

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.584

High

652556

SMRC1
SWI/SNF complex subunit SMARCC1

2

20

Small-scale

0.584

High

652559

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

15

Small-scale

0.584

High

239354

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

2

Small-scale

0.578

High

407982

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.578

High

652474

VASP
Vasodilator-stimulated phosphoprotein

1

11

High-throughput

0.578

High

652593

AKIB1
Ankyrin repeat and IBR domain-containing protein 1

1

6

High-throughput

0.578

High

652469

GRK6
G protein-coupled receptor kinase 6

2

15

High-throughput

0.574

High

652530

TMTC4
Protein O-mannosyl-transferase TMTC4

2

15

High-throughput

0.574

High

652455

GLPK
Glycerol kinase

1

2

High-throughput

0.573

High

652465

STAT3
Signal transducer and activator of transcription 3

1

19

High-throughput

0.573

High

652526

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

20

High-throughput

0.573

High

652450

PML
Protein PML

1

20

Small-scale

0.561

High

652453

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.561

High

652464

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.561

High

652495

TF65
Transcription factor p65

1

20

Small-scale

0.561

High

652500

TRAF2
TNF receptor-associated factor 2

1

19

Small-scale

0.561

High

652507

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.561

High

652550

NDRG1
Protein NDRG1

1

1

Small-scale

0.561

High

260674

CUTA
Protein CutA

1

0

High-throughput

0.554

High

652458

PPM1A
Protein phosphatase 1A

1

2

High-throughput

0.541

High

652509

ATM
Serine-protein kinase ATM

1

14

High-throughput

0.541

High

652595

KS6A6
Ribosomal protein S6 kinase alpha-6

1

17

High-throughput

0.541

High

652570

ANM1
Protein arginine N-methyltransferase 1

1

17

Small-scale

0.534

High

652524

B2LA1
Bcl-2-related protein A1

1

7

Small-scale

0.515

High

652484

KR105
Keratin-associated protein 10-5

1

14

High-throughput

0.515

High

652463

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

0

Small-scale

0.511

High

176757

NACAD
NAC-alpha domain-containing protein 1

1

20

High-throughput

0.508

High

390319

CXCL7
Platelet basic protein

1

2

High-throughput

0.508

High

587002

ITF2
Transcription factor 4

1

1

High-throughput

0.508

High

612503

RL7
Large ribosomal subunit protein uL30

1

4

High-throughput

0.508

High

650597

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

20

High-throughput

0.508

High

652479

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

652499

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.508

High

652514

HES1
Transcription factor HES-1

1

3

High-throughput

0.508

High

652541

ZN579
Zinc finger protein 579

1

14

High-throughput

0.508

High

652585

RTN4
Reticulon-4

1

4

High-throughput

0.508

High

652586

ZN331
Zinc finger protein 331

1

11

High-throughput

0.508

High

652599

FAF1
FAS-associated factor 1

1

6

High-throughput

0.508

High

652609

CD2AP
CD2-associated protein

1

11

High-throughput

0.508

High

652506

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

Small-scale

0.501

High

652522

STK11
Serine/threonine-protein kinase STK11

1

6

Small-scale

0.501

High

652554

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.501

High

652516

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.494

High

652584

B2L10
Bcl-2-like protein 10

1

0

Small-scale

0.493

High

652513

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.486

High

652580

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.486

High

652605

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.486

High

332081

MRP6
ATP-binding cassette sub-family C member 6

1

7

High-throughput

0.481

High

354904

CHK2
Serine/threonine-protein kinase Chk2

1

14

High-throughput

0.481

High

626069

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

High-throughput

0.481

High

652449

RBL1
Retinoblastoma-like protein 1

1

3

High-throughput

0.481

High

652452

PRDX6
Peroxiredoxin-6

1

13

High-throughput

0.481

High

652466

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.481

High

652473

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

3

High-throughput

0.481

High

652483

KR101
Keratin-associated protein 10-1

1

15

High-throughput

0.481

High

652498

ARHG5
Rho guanine nucleotide exchange factor 5

1

20

High-throughput

0.481

High

652537

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

20

High-throughput

0.481

High

652604

SGT1
Protein SGT1 homolog

1

12

High-throughput

0.481

High

141324

DDX3X
ATP-dependent RNA helicase DDX3X

1

11

Small-scale

0.479

High

177653

SMAD7
Mothers against decapentaplegic homolog 7

1

12

Small-scale

0.479

High

207443

DHX15
ATP-dependent RNA helicase DHX15

1

11

Small-scale

0.479

High

209480

SERA
D-3-phosphoglycerate dehydrogenase

1

7

Small-scale

0.479

High

210484

SEPT4
Septin-4

1

10

High-throughput

0.479

High

214705

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

16

Small-scale

0.479

High

228681

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

20

Small-scale

0.479

High

228964

AKAP8
A-kinase anchor protein 8

1

9

Small-scale

0.479

High

250460

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

16

Small-scale

0.479

High

257748

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.479

High

271225

CPNE3
Copine-3

1

2

Small-scale

0.479

High

297456

PIAS1
E3 SUMO-protein ligase PIAS1

1

16

Small-scale

0.479

High

297754

PIAS2
E3 SUMO-protein ligase PIAS2

1

16

Small-scale

0.479

High

316749

MTA2
Metastasis-associated protein MTA2

1

20

Small-scale

0.479

High

652496

LG3BP
Galectin-3-binding protein

1

6

Small-scale

0.479

High

652501

STK4
Serine/threonine-protein kinase 4

1

20

Small-scale

0.479

High

652502

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.479

High

652504

STK3
Serine/threonine-protein kinase 3

1

11

Small-scale

0.479

High

652505

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

2

Small-scale

0.479

High

652508

PABP4
Polyadenylate-binding protein 4

1

17

Small-scale

0.479

High

652511

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

652512

KEAP1
Kelch-like ECH-associated protein 1

1

4

Small-scale

0.479

High

652515

LBR
Delta(14)-sterol reductase LBR

1

3

Small-scale

0.479

High

652518

NONO
Non-POU domain-containing octamer-binding protein

1

20

Small-scale

0.479

High

652520

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

6

Small-scale

0.479

High

652525

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.479

High

652527

PPCEL
Prolyl endopeptidase-like

1

2

High-throughput

0.479

High

652529

ZN326
DBIRD complex subunit ZNF326

1

9

Small-scale

0.479

High

652531

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

20

Small-scale

0.479

High

652532

RN111
E3 ubiquitin-protein ligase Arkadia

1

16

Small-scale

0.479

High

652534

TBA1A
Tubulin alpha-1A chain

1

19

Small-scale

0.479

High

652535

YTHD3
YTH domain-containing family protein 3

1

9

Small-scale

0.479

High

336623

BAG4
BAG family molecular chaperone regulator 4

1

2

Small-scale

0.479

High

341521

EYA4
Protein phosphatase EYA4

1

18

Small-scale

0.479

High

345374

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

Small-scale

0.479

High

430578

FABPH
Fatty acid-binding protein, heart

1

9

High-throughput

0.479

High

451482

CENPB
Major centromere autoantigen B

1

5

High-throughput

0.479

High

452165

PDIA1
Protein disulfide-isomerase

1

9

Small-scale

0.479

High

474479

VIME
Vimentin

1

20

Small-scale

0.479

High

521541

H14
Histone H1.4

1

5

Small-scale

0.479

High

533589

CLUS
Clusterin

1

3

High-throughput

0.479

High

534635

BIP
Endoplasmic reticulum chaperone BiP

1

19

Small-scale

0.479

High

536509

HSP7C
Heat shock cognate 71 kDa protein

1

15

Small-scale

0.479

High

542333

TOP2A
DNA topoisomerase 2-alpha

1

7

Small-scale

0.479

High

550121

PABP1
Polyadenylate-binding protein 1

1

17

Small-scale

0.479

High

551951

ADT1
ADP/ATP translocase 1

1

12

Small-scale

0.479

High

552503

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

Small-scale

0.479

High

559222

XRCC5
X-ray repair cross-complementing protein 5

1

11

Small-scale

0.479

High

576283

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

20

Small-scale

0.479

High

595939

H12
Histone H1.2

1

5

Small-scale

0.479

High

608452

DDX5
Probable ATP-dependent RNA helicase DDX5

1

12

Small-scale

0.479

High

610530

TCPA
T-complex protein 1 subunit alpha

1

10

Small-scale

0.479

High

612871

EGR1
Early growth response protein 1

1

13

Small-scale

0.479

High

652448

PTBP1
Polypyrimidine tract-binding protein 1

1

20

Small-scale

0.479

High

652454

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

Small-scale

0.479

High

652457

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

3

Small-scale

0.479

High

652459

K22E
Keratin, type II cytoskeletal 2 epidermal

1

19

Small-scale

0.479

High

652461

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

652462

TCPZ
T-complex protein 1 subunit zeta

1

10

Small-scale

0.479

High

652468

MATR3
Matrin-3

1

11

High-throughput

0.479

High

652475

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

20

Small-scale

0.479

High

652476

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

652477

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

18

Small-scale

0.479

High

652480

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.479

High

652482

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

20

Small-scale

0.479

High

652485

PRS4
26S proteasome regulatory subunit 4

1

20

Small-scale

0.479

High

652486

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.479

High

652487

H4
Histone H4

1

3

High-throughput

0.479

High

652488

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

652489

EF1A1
Elongation factor 1-alpha 1

1

10

Small-scale

0.479

High

652491

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.479

High

652492

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

Small-scale

0.479

High

652493

TCPB
T-complex protein 1 subunit beta

1

13

Small-scale

0.479

High

652539

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

20

Small-scale

0.479

High

652540

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

15

Small-scale

0.479

High

652542

FA98A
Protein FAM98A

1

2

Small-scale

0.479

High

652543

G45IP
Large ribosomal subunit protein mL64

1

1

Small-scale

0.479

High

652545

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

Small-scale

0.479

High

652546

PHIP
PH-interacting protein

1

20

High-throughput

0.479

High

652547

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

7

Small-scale

0.479

High

652551

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

652552

TFG
Protein TFG

1

12

Small-scale

0.479

High

652553

RBP56
TATA-binding protein-associated factor 2N

1

17

Small-scale

0.479

High

652555

RENT1
Regulator of nonsense transcripts 1

1

11

Small-scale

0.479

High

652557

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

20

Small-scale

0.479

High

652558

FUBP2
Far upstream element-binding protein 2

1

16

Small-scale

0.479

High

652561

OTUB2
Ubiquitin thioesterase OTUB2

1

2

Small-scale

0.479

High

652563

OTUB1
Ubiquitin thioesterase OTUB1

1

2

Small-scale

0.479

High

652564

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

20

Small-scale

0.479

High

652565

FUBP3
Far upstream element-binding protein 3

1

16

Small-scale

0.479

High

652568

EYA1
Protein phosphatase EYA1

1

20

Small-scale

0.479

High

652569

TCPH
T-complex protein 1 subunit eta

1

12

Small-scale

0.479

High

652571

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.479

High

652572

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.479

High

652573

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

20

Small-scale

0.479

High

652574

NUSAP
Nucleolar and spindle-associated protein 1

1

1

Small-scale

0.479

High

652576

ESF1
ESF1 homolog

1

3

High-throughput

0.479

High

652577

NT5D2
5'-nucleotidase domain-containing protein 2

1

2

Small-scale

0.479

High

652578

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

10

Small-scale

0.479

High

652579

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

18

Small-scale

0.479

High

652581

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

4

Small-scale

0.479

High

652588

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

20

Small-scale

0.479

High

652589

DD19A
ATP-dependent RNA helicase DDX19A

1

20

Small-scale

0.479

High

652590

RNF12
E3 ubiquitin-protein ligase RLIM

1

13

Small-scale

0.479

High

652592

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

Small-scale

0.479

High

652594

HDAC6
Protein deacetylase HDAC6

1

20

Small-scale

0.479

High

652596

AGO2
Protein argonaute-2

1

2

Small-scale

0.479

High

652597

MYT1L
Myelin transcription factor 1-like protein

1

5

High-throughput

0.479

High

652600

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

11

Small-scale

0.479

High

652601

CHM2B
Charged multivesicular body protein 2b

1

3

High-throughput

0.479

High

652602

AXIN2
Axin-2

1

3

Small-scale

0.479

High

652603

YBOX2
Y-box-binding protein 2

1

5

Small-scale

0.479

High

652606

RTCB
RNA-splicing ligase RtcB homolog

1

2

Small-scale

0.479

High

652607

DCAF1
DDB1- and CUL4-associated factor 1

1

15

High-throughput

0.479

High

652612

PIAS3
E3 SUMO-protein ligase PIAS3

1

16

Small-scale

0.479

High

652451

KAIN
Kallistatin

1

7

High-throughput

0.464

High

652608

PLXD1
Plexin-D1

1

5

Small-scale

0.462

High

359594

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.460

High

652575

ABCG8
ATP-binding cassette sub-family G member 8

1

0

High-throughput

0.460

High

652587

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.460

High

207735

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

Small-scale

0.458

High

572990

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

652467

ID1
DNA-binding protein inhibitor ID-1

1

0

Small-scale

0.458

High

652562

ESS2
Splicing factor ESS-2 homolog

1

0

Small-scale

0.458

High

652567

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

652582

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

12

High-throughput

0.457

High

333886

ABCBB
Bile salt export pump

1

4

High-throughput

0.439

High

425215

IC1
Plasma protease C1 inhibitor

1

9

High-throughput

0.439

High

652472

LSS
Lanosterol synthase

1

1

High-throughput

0.439

High

652548

ABCA5
Cholesterol transporter ABCA5

1

4

High-throughput

0.439

High

652549

SOCS4
Suppressor of cytokine signaling 4

1

19

High-throughput

0.439

High

299736

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.437

High

652490

TBA1B
Tubulin alpha-1B chain

1

19

Small-scale

0.437

High

652536

PRP39
Pre-mRNA-processing factor 39

1

13

Small-scale

0.437

High

652538

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

16

High-throughput

0.437

High

652560

CCD47
PAT complex subunit CCDC47

1

3

Small-scale

0.437

High

652591

TMOD3
Tropomodulin-3

1

7

Small-scale

0.437

High

652598

PCDGK
Protocadherin gamma-C3

1

1

High-throughput

0.437

High

652544

BBS10
BBSome complex assembly protein BBS10

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025