HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	34878901, 35563538, 21145461, 19295130, 28514442, 33961781, 19615732, 37207277
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 327
+	Hs
		124855 CUL3_HUMAN (1-768): 0: 951: 100.00		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	Hs
		849195 CUL3_HUMAN (1-768): 0: 951: 100.00		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Hs
		1043079 CUL4A_HUMAN (10-768): 0: 791: 38.32		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1043429 CUL4B_HUMAN (5-768): 0: 779: 36.77		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		91398 CUL4B_HUMAN (5-768): 0: 779: 36.77		E7EM64_HUMAN (1-327): 1.07e-139: 399: 99.69
+	Hs
		1041064 CUL1_HUMAN (18-768): 0: 707: 30.57		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1041373 CUL2_HUMAN (30-768): 0: 672: 26.17		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		1184935 CUL5_HUMAN (25-768): 0: 597: 23.77		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Hs
		177020 CUL4A_HUMAN (10-768): 0: 791: 38.32		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	Ce
		954204 CUL3_CAEEL (4-768): 0: 792: 48.08		CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95