HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19256485
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 201
+	Hs
		1042223 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		919724 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849325 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851812 CUL3_HUMAN (1-768): 0: 951: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		896438 CUL3_HUMAN (1-768): 0: 951: 100.00		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		1043149 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		849326 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		895791 CUL4A_HUMAN (10-768): 0: 791: 38.32		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		895792 CUL4B_HUMAN (5-768): 0: 779: 36.77		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		828994 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBE2A_HUMAN (54-198): 1.67e-70: 212: 35.86
+	Hs
		1041136 CUL1_HUMAN (18-768): 0: 707: 30.57		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	At
		1228143 CUL4_ARATH (8-768): 0: 744: 38.61		COP10_ARATH (43-200): 9e-62: 191: 55.98
+	Hs
		849324 CUL2_HUMAN (30-768): 0: 672: 26.17		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		895790 CUL2_HUMAN (30-768): 0: 672: 26.17		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Dm
		639393 CUL1_DROME (29-768): 0: 669: 27.49		UBCD1_DROME (55-200): 1.11e-81: 240: 64.38
+	Sp
		804458 CUL3_SCHPO (11-768): 0: 648: 37.04		UBC4_SCHPO (55-200): 6.49e-81: 239: 65.07