Protein: MAT1
CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)

Gene: MAT1, MNAT1
Organism: Homo sapiens
Interactions: 123
UniProt ID: P51948

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0000439 - transcription factor TFIIH core complex
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897172

CDK7
Cyclin-dependent kinase 7

20

7

Small-scale

0.988

High

622782

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

8

1

Small-scale

0.966

High

611658

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

7

3

Small-scale

0.964

High

667666

CDK2
Cyclin-dependent kinase 2

2

3

High-throughput

0.776

High

908687

CCNH
Cyclin-H

8

7

Small-scale

0.748

High

744644

TF2H1
General transcription factor IIH subunit 1

4

2

Small-scale

0.694

High

132455

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.691

High

908745

TF2H2
General transcription factor IIH subunit 2

3

2

Small-scale

0.660

High

395726

ESR1
Estrogen receptor

3

0

Small-scale

0.632

High

413451

P53
Cellular tumor antigen p53

2

0

Small-scale

0.619

High

881496

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.618

High

798871

BRCA1
Breast cancer type 1 susceptibility protein

2

7

Small-scale

0.614

High

573781

CCNB1
G2/mitotic-specific cyclin-B1

2

1

High-throughput

0.601

High

908772

TF2H4
General transcription factor IIH subunit 4

2

2

High-throughput

0.601

High

667224

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.577

High

704731

ERCC5
DNA excision repair protein ERCC-5

2

0

High-throughput

0.576

High

908796

CILK1
Serine/threonine-protein kinase ICK

1

3

Small-scale

0.553

High

756133

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.549

High

908743

MTA1
Metastasis-associated protein MTA1

1

0

Small-scale

0.549

High

623205

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

High-throughput

0.541

High

908740

TRI26
Tripartite motif-containing protein 26

1

7

High-throughput

0.541

High

908769

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

5

High-throughput

0.541

High

908779

TRI34
E3 ubiquitin-protein ligase TRIM34

1

6

High-throughput

0.541

High

908780

TRI31
E3 ubiquitin-protein ligase TRIM31

1

9

High-throughput

0.541

High

908781

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

8

High-throughput

0.541

High

908782

TRIM5
Tripartite motif-containing protein 5

1

7

High-throughput

0.541

High

908783

TRIM2
Tripartite motif-containing protein 2

1

4

High-throughput

0.541

High

908786

RNF41
E3 ubiquitin-protein ligase NRDP1

1

7

High-throughput

0.541

High

908789

TRI39
E3 ubiquitin-protein ligase TRIM39

1

6

High-throughput

0.541

High

908793

RBX2
RING-box protein 2

1

1

High-throughput

0.541

High

908798

TRI17
E3 ubiquitin-protein ligase TRIM17

1

5

High-throughput

0.541

High

908785

FOXP1
Forkhead box protein P1

1

0

High-throughput

0.536

High

651122

CCNO
Cyclin-O

1

2

High-throughput

0.536

High

908738

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

908749

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

908755

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

908790

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

Small-scale

0.529

High

576193

PO2F1
POU domain, class 2, transcription factor 1

1

2

Small-scale

0.527

High

179693

MDM4
Protein Mdm4

1

0

High-throughput

0.518

High

540828

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

908741

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.518

High

908751

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

908760

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

908763

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.518

High

908784

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

241149

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.515

High

142509

IMA3
Importin subunit alpha-3

1

0

High-throughput

0.513

High

261482

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

574046

HXB1
Homeobox protein Hox-B1

1

0

High-throughput

0.513

High

628731

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

832882

CETN2
Centrin-2

1

0

High-throughput

0.513

High

908727

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

908748

ZN174
Zinc finger protein 174

1

0

High-throughput

0.513

High

908759

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

908765

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

908766

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

908777

ZN747
Zinc finger protein 747

1

0

High-throughput

0.513

High

908787

CAPAM
mRNA

1

0

High-throughput

0.513

High

478905

PO2F2
POU domain, class 2, transcription factor 2

1

2

Small-scale

0.501

High

507704

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

908735

PO5F1
POU domain, class 5, transcription factor 1

1

2

Small-scale

0.501

High

843398

HD
Huntingtin

1

0

High-throughput

0.493

High

908742

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

908797

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

908799

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

1

High-throughput

0.489

High

481168

HMGB1
High mobility group protein B1

1

1

Small-scale

0.481

High

908747

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.481

High

908792

MAGC2
Melanoma-associated antigen C2

1

1

Small-scale

0.481

High

130407

SPT5H
Transcription elongation factor SPT5

1

0

Small-scale

0.480

High

442644

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.480

High

302437

RNF8
E3 ubiquitin-protein ligase RNF8

1

4

Small-scale

0.479

High

908729

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

908731

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

908758

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

288379

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

High-throughput

0.460

High

908752

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

908776

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.460

High

259656

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

371519

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

464883

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

588255

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

606464

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

694980

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

767749

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

908739

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

908744

CUL3
Cullin-3

1

0

High-throughput

0.458

High

908761

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

908773

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

908774

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

908778

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

908788

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

908791

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

629089

CCNA2
Cyclin-A2

1

1

High-throughput

0.445

High

908746

TF2H3
General transcription factor IIH subunit 3

1

1

High-throughput

0.445

High

908756

T2H2L
General transcription factor IIH subunit 2-like protein

1

2

High-throughput

0.445

High

908770

MAGE2
Melanoma-associated antigen E2

1

1

Small-scale

0.439

High

908753

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

425718

PERM
Myeloperoxidase

1

0

High-throughput

0.426

High

249108

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

908732

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.282

High

908737

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.282

High

224475

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

273840

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.279

Low

322495

ABLM3
Actin-binding LIM protein 3

1

0

High-throughput

0.279

Low

335379

GDF11
Growth/differentiation factor 11

1

0

High-throughput

0.279

Low

721447

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

0

High-throughput

0.279

Low

908736

LMNB2
Lamin-B2

1

0

High-throughput

0.279

Low

908754

CK071
Uncharacterized protein C11orf71

1

0

High-throughput

0.279

Low

908762

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

908767

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.279

Low

908764

CAD26
Cadherin-like protein 26

1

0

High-throughput

0.269

Low

908734

BEX3
Protein BEX3

1

0

High-throughput

0.251

Low

908730

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.249

Low

908775

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

908794

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

908771

TSC1
Hamartin

1

0

Small-scale

0.238

Low

721471

GSTT1
Glutathione S-transferase theta-1

1

0

High-throughput

0.232

Low

908728

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.232

Low

908733

FBLN2
Fibulin-2

1

0

High-throughput

0.232

Low

908750

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

908757

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

908768

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low

908795

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025