HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 446
+	Hs
		1043191 CUL4A_HUMAN (10-768): 0: 791: 38.32		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		1043542 CUL4B_HUMAN (5-768): 0: 779: 36.77		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		903207 CUL3_HUMAN (1-768): 0: 951: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		1041172 CUL1_HUMAN (18-768): 0: 707: 30.57		GRWD1_HUMAN (1-446): 4.56e-121: 361: 100.00
+	Hs
		1041672 CUL3_HUMAN (1-768): 0: 951: 100.00		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997713 CUL3_HUMAN (1-768): 0: 951: 100.00		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1041647 CUL3_HUMAN (1-768): 0: 951: 100.00		TAF5_HUMAN (297-445): 3.11e-19: 92.4: 11.44
+	Hs
		1042655 CUL3_HUMAN (1-768): 0: 951: 100.00		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89
+	Hs
		903208 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		903209 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		792982 CUL4A_HUMAN (10-768): 0: 791: 38.32		LIS1_HUMAN (243-445): 6.45e-42: 155: 17.00
+	Hs
		1043562 CUL4B_HUMAN (5-768): 0: 779: 36.77		TBL1R_HUMAN (94-292): 5.97e-27: 115: 14.08
+	Hs
		1043016 CUL4A_HUMAN (10-768): 0: 791: 38.32		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997714 CUL4A_HUMAN (10-768): 0: 791: 38.32		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		903206 CUL1_HUMAN (18-768): 0: 707: 30.57		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		1043376 CUL4B_HUMAN (5-768): 0: 779: 36.77		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997715 CUL4B_HUMAN (5-768): 0: 779: 36.77		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1043085 CUL4A_HUMAN (10-768): 0: 791: 38.32		WDR5B_HUMAN (348-445): 9.02e-15: 76.9: 16.33
+	Hs
		1043441 CUL4B_HUMAN (5-768): 0: 779: 36.77		WDR5B_HUMAN (348-445): 9.02e-15: 76.9: 16.33
+	At
		186930 CUL4_ARATH (8-768): 0: 744: 38.61		MSI1_ARATH (307-445): 6.04e-14: 75.4: 16.89