Protein: KAT2A
Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)

Gene: KAT2A
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q92830

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000123 - histone acetyltransferase complex
GO:0000124 - SAGA complex
GO:0001701 - in utero embryonic development
GO:0001756 - somitogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

283519

TAD2A
Transcriptional adapter 2-alpha

10

20

Small-scale

0.972

High

1369160

CSR2B
Cysteine-rich protein 2-binding protein

6

7

Small-scale

0.935

High

284971

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

5

20

Small-scale

0.912

High

1315029

ZZZ3
ZZ-type zinc finger-containing protein 3

5

3

Small-scale

0.909

High

1287313

TAD2B
Transcriptional adapter 2-beta

3

20

High-throughput

0.827

High

1369143

KAT2A
Histone acetyltransferase KAT2A

2

18

Small-scale

0.757

High

1369150

SGF29
SAGA-associated factor 29

11

3

Small-scale

0.756

High

1369180

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

11

13

Small-scale

0.754

High

1135630

AT7L3
Ataxin-7-like protein 3

11

4

Small-scale

0.754

High

1369185

TRRAP
Transformation/transcription domain-associated protein

11

19

Small-scale

0.752

High

372742

MYC
Myc proto-oncogene protein

8

20

Small-scale

0.750

High

284854

TADA3
Transcriptional adapter 3

9

8

Small-scale

0.749

High

184735

ATX7
Ataxin-7

9

20

Small-scale

0.748

High

283615

SUPT3
Transcription initiation protein SPT3 homolog

9

6

Small-scale

0.747

High

1369167

MBIP1
MAP3K12-binding inhibitory protein 1

7

4

Small-scale

0.742

High

1159319

TAF9
Transcription initiation factor TFIID subunit 9

7

13

Small-scale

0.739

High

1369144

KAT2B
Histone acetyltransferase KAT2B

2

20

Small-scale

0.737

High

1369184

MED16
Mediator of RNA polymerase II transcription subunit 16

2

2

Small-scale

0.737

High

1091639

TAF10
Transcription initiation factor TFIID subunit 10

7

12

Small-scale

0.735

High

965131

WDR5
WD repeat-containing protein 5

6

20

Small-scale

0.730

High

980082

H4
Histone H4

6

20

Small-scale

0.728

High

998632

H31
Histone H3.1

6

20

Small-scale

0.728

High

1337573

SP20H
Transcription factor SPT20 homolog

6

3

Small-scale

0.726

High

1369148

TADA1
Transcriptional adapter 1

6

3

High-throughput

0.724

High

1369170

DTL
Denticleless protein homolog

1

20

Small-scale

0.724

High

848812

MAGAA
Melanoma-associated antigen 10

5

11

High-throughput

0.716

High

1369189

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

5

14

High-throughput

0.714

High

1029128

E2F1
Transcription factor E2F1

5

15

Small-scale

0.699

High

1157594

TAF12
Transcription initiation factor TFIID subunit 12

4

8

High-throughput

0.691

High

1369156

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.687

High

1031934

NC2B
Protein Dr1

4

11

Small-scale

0.686

High

1147984

SF3B3
Splicing factor 3B subunit 3

4

14

High-throughput

0.686

High

319163

ST65G
STAGA complex 65 subunit gamma

4

1

Small-scale

0.676

High

1369162

TAF9B
Transcription initiation factor TFIID subunit 9B

4

13

Small-scale

0.676

High

1369177

YETS2
YEATS domain-containing protein 2

4

20

Small-scale

0.676

High

1369163

ENY2
Transcription and mRNA export factor ENY2

3

5

Small-scale

0.656

High

519408

MYB
Transcriptional activator Myb

1

8

Small-scale

0.647

High

414334

P53
Cellular tumor antigen p53

3

20

Small-scale

0.646

High

606967

CEBPB
CCAAT/enhancer-binding protein beta

2

20

Small-scale

0.639

High

291948

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

20

Small-scale

0.634

High

1151275

MED1
Mediator of RNA polymerase II transcription subunit 1

3

20

Small-scale

0.633

High

1045598

TF65
Transcription factor p65

2

14

Small-scale

0.629

High

1369159

IKZF5
Zinc finger protein Pegasus

2

15

High-throughput

0.628

High

1157842

DDB1
DNA damage-binding protein 1

2

14

Small-scale

0.624

High

881574

CDK8
Cyclin-dependent kinase 8

2

20

Small-scale

0.621

High

260249

BRD4
Bromodomain-containing protein 4

1

18

High-throughput

0.618

High

822789

VHL
von Hippel-Lindau disease tumor suppressor

1

4

High-throughput

0.618

High

1007748

RAE1L
mRNA export factor RAE1

1

20

High-throughput

0.618

High

1218890

TAF3
Transcription initiation factor TFIID subunit 3

1

20

Small-scale

0.618

High

1369183

WDR37
WD repeat-containing protein 37

1

20

High-throughput

0.618

High

1161978

H31T
Histone H3.1t

2

20

Small-scale

0.613

High

1369158

SF3B5
Splicing factor 3B subunit 5

2

2

High-throughput

0.611

High

587509

TFE2
Transcription factor E2-alpha

2

11

Small-scale

0.602

High

1162854

H2A2C
Histone H2A type 2-C

2

20

Small-scale

0.602

High

1163110

H2B2E
Histone H2B type 2-E

2

20

Small-scale

0.602

High

1369145

MED12
Mediator of RNA polymerase II transcription subunit 12

2

20

Small-scale

0.601

High

764936

CTNB1
Catenin beta-1

2

20

Small-scale

0.595

High

959626

MAX
Protein max

2

20

Small-scale

0.584

High

1369149

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

17

Small-scale

0.584

High

696108

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

Small-scale

0.578

High

334312

TACC2
Transforming acidic coiled-coil-containing protein 2

1

20

Small-scale

0.573

High

558304

XRCC6
X-ray repair cross-complementing protein 6

1

16

Small-scale

0.573

High

396647

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1369168

MED17
Mediator of RNA polymerase II transcription subunit 17

2

2

Small-scale

0.571

High

789539

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.563

High

533959

IRF1
Interferon regulatory factor 1

1

14

Small-scale

0.561

High

823854

PBX1
Pre-B-cell leukemia transcription factor 1

1

2

Small-scale

0.561

High

1112941

CUL2
Cullin-2

1

20

Small-scale

0.561

High

1144107

TEBP
Prostaglandin E synthase 3

1

3

Small-scale

0.561

High

1328833

COMD1
COMM domain-containing protein 1

1

1

Small-scale

0.561

High

591759

H2AX
Histone H2AX

1

20

Small-scale

0.536

High

682567

S100P
Protein S100-P

1

6

High-throughput

0.536

High

848693

MAGA9
Melanoma-associated antigen 9

1

11

High-throughput

0.536

High

911330

IMA5
Importin subunit alpha-5

1

15

High-throughput

0.536

High

975162

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.536

High

1099746

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

4

High-throughput

0.536

High

1369164

DPOE4
DNA polymerase epsilon subunit 4

1

6

High-throughput

0.536

High

1323662

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

0

High-throughput

0.518

High

243695

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.515

High

1040874

MECOM
Histone-lysine N-methyltransferase MECOM

1

16

High-throughput

0.515

High

1369182

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.513

High

717121

ECHM
Enoyl-CoA hydratase, mitochondrial

1

6

Small-scale

0.512

High

1010017

DHI2
11-beta-hydroxysteroid dehydrogenase type 2

1

1

Small-scale

0.512

High

1369169

AATF
Protein AATF

1

4

Small-scale

0.506

High

210075

CRX
Cone-rod homeobox protein

1

20

Small-scale

0.501

High

281074

TACC1
Transforming acidic coiled-coil-containing protein 1

1

16

Small-scale

0.501

High

419116

H2A1B
Histone H2A type 1-B/E

1

20

Small-scale

0.501

High

571626

IRF2
Interferon regulatory factor 2

1

14

Small-scale

0.501

High

595541

H15
Histone H1.5

1

16

Small-scale

0.501

High

662475

GATA2
Endothelial transcription factor GATA-2

1

20

Small-scale

0.501

High

667001

CCNE1
G1/S-specific cyclin-E1

1

10

High-throughput

0.501

High

667958

CDK2
Cyclin-dependent kinase 2

1

11

Small-scale

0.501

High

718833

CCND2
G1/S-specific cyclin-D2

1

12

High-throughput

0.501

High

728361

AKT1
RAC-alpha serine/threonine-protein kinase

1

11

High-throughput

0.501

High

754928

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.501

High

767288

MERL
Merlin

1

11

High-throughput

0.501

High

791597

SYUA
Alpha-synuclein

1

3

High-throughput

0.501

High

842927

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

12

High-throughput

0.501

High

858691

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

11

High-throughput

0.501

High

993688

UBC9
SUMO-conjugating enzyme UBC9

1

17

Small-scale

0.501

High

1008269

PRKDC
DNA-dependent protein kinase catalytic subunit

1

19

Small-scale

0.501

High

1025400

CDK6
Cyclin-dependent kinase 6

1

10

High-throughput

0.501

High

1099656

GRM1
Metabotropic glutamate receptor 1

1

1

High-throughput

0.501

High

1154410

STK11
Serine/threonine-protein kinase STK11

1

3

High-throughput

0.501

High

1158148

MK14
Mitogen-activated protein kinase 14

1

12

High-throughput

0.501

High

1258899

H32
Histone H3.2

1

20

Small-scale

0.501

High

1364953

TSC1
Hamartin

1

20

High-throughput

0.501

High

1369152

H4G
Histone H4-like protein type G

1

20

Small-scale

0.501

High

1369165

LATS2
Serine/threonine-protein kinase LATS2

1

10

High-throughput

0.501

High

1369166

RASF1
Ras association domain-containing protein 1

1

3

High-throughput

0.501

High

1369178

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.501

High

1369187

TACC3
Transforming acidic coiled-coil-containing protein 3

1

20

Small-scale

0.501

High

1369188

EID1
EP300-interacting inhibitor of differentiation 1

1

1

Small-scale

0.501

High

1054753

SUH
Recombining binding protein suppressor of hairless

1

4

Small-scale

0.481

High

1126732

BECN1
Beclin-1

1

0

High-throughput

0.480

High

130782

TAF4
Transcription initiation factor TFIID subunit 4

1

20

Small-scale

0.479

High

181916

SMAD9
Mothers against decapentaplegic homolog 9

1

20

Small-scale

0.479

High

213982

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

251792

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

12

Small-scale

0.479

High

317204

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

12

Small-scale

0.479

High

339815

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

358765

LDHA
L-lactate dehydrogenase A chain

1

9

High-throughput

0.479

High

457595

TBB5
Tubulin beta chain

1

10

Small-scale

0.479

High

467795

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

549209

CDK4
Cyclin-dependent kinase 4

1

11

Small-scale

0.479

High

559442

XRCC5
X-ray repair cross-complementing protein 5

1

16

Small-scale

0.479

High

581705

MYOD1
Myoblast determination protein 1

1

20

High-throughput

0.479

High

608983

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

675609

TYY1
Transcriptional repressor protein YY1

1

20

High-throughput

0.479

High

739013

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

777529

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.479

High

787886

SRBP1
Sterol regulatory element-binding protein 1

1

20

Small-scale

0.479

High

827874

STAT3
Signal transducer and activator of transcription 3

1

13

Small-scale

0.479

High

834009

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

892058

TAF6
Transcription initiation factor TFIID subunit 6

1

14

High-throughput

0.479

High

908434

HDGF
Hepatoma-derived growth factor

1

20

High-throughput

0.479

High

944713

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

1014569

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

1017077

H33
Histone H3.3

1

20

Small-scale

0.479

High

1088941

TP53B
TP53-binding protein 1

1

11

High-throughput

0.479

High

1103303

CTBP1
C-terminal-binding protein 1

1

11

Small-scale

0.479

High

1114976

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1122124

UBP2L
Ubiquitin-associated protein 2-like

1

20

Small-scale

0.479

High

1133572

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1146958

PCBP2
Poly(rC)-binding protein 2

1

18

High-throughput

0.479

High

1153855

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

1153985

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

1156800

E2F4
Transcription factor E2F4

1

15

Small-scale

0.479

High

1241478

EDC4
Enhancer of mRNA-decapping protein 4

1

20

High-throughput

0.479

High

1273925

PTF1A
Pancreas transcription factor 1 subunit alpha

1

19

Small-scale

0.479

High

1312358

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

17

Small-scale

0.479

High

1315291

TRI22
E3 ubiquitin-protein ligase TRIM22

1

7

Small-scale

0.479

High

1351108

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1366938

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1369146

LHX4
LIM/homeobox protein Lhx4

1

17

High-throughput

0.479

High

1369153

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1369154

SMAD5
Mothers against decapentaplegic homolog 5

1

20

Small-scale

0.479

High

1369155

MBB1A
Myb-binding protein 1A

1

3

High-throughput

0.479

High

1369171

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.479

High

1369172

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

1369173

HDAC6
Protein deacetylase HDAC6

1

20

High-throughput

0.479

High

1369179

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

High-throughput

0.479

High

1369181

ZN148
Zinc finger protein 148

1

18

Small-scale

0.479

High

1369186

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

584788

NDKA
Nucleoside diphosphate kinase A

1

0

Small-scale

0.458

High

946671

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

Small-scale

0.458

High

1369151

ADAT3
Probable inactive tRNA-specific adenosine deaminase-like protein 3

1

0

High-throughput

0.458

High

58891

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

11

High-throughput

0.445

High

239601

MED14
Mediator of RNA polymerase II transcription subunit 14

1

20

Small-scale

0.445

High

282404

MED24
Mediator of RNA polymerase II transcription subunit 24

1

4

Small-scale

0.445

High

1369147

FUBP1
Far upstream element-binding protein 1

1

20

Small-scale

0.445

High

1369174

MED13
Mediator of RNA polymerase II transcription subunit 13

1

3

Small-scale

0.445

High

1369176

MED23
Mediator of RNA polymerase II transcription subunit 23

1

5

Small-scale

0.445

High

1213427

AT7L2
Ataxin-7-like protein 2

1

9

High-throughput

0.437

High

1364458

WASF1
Actin-binding protein WASF1

1

15

High-throughput

0.437

High

1369175

AT7L1
Ataxin-7-like protein 1

1

17

High-throughput

0.437

High

127152

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

887072

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.408

High

1369161

PLAC1
Placenta-specific protein 1

2

0

High-throughput

0.328

High

755504

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

1369157

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025