HitPredict

Interactor 1: FKBP6 (O75344)
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (36 kDa FKBP) (FKBP-36) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36)
Gene: FKBP6

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~HSP90
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 724
+	Hs
		111930 FKBP6_HUMAN (1-327): 4.19e-82: 253: 100.00		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		259914 FKBP6_HUMAN (1-327): 4.19e-82: 253: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438089 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		111936 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431755 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Mm
		432409 FKBP4_MOUSE (2-327): 6.15e-73: 234: 23.64		HS90A_MOUSE (1-724): 0: 1068: 84.31
+	Hs
		438136 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		111937 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431818 FKBP5_HUMAN (2-327): 2.72e-66: 216: 22.73		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438169 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431850 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432312 AIPL1_HUMAN (36-317): 4.56e-56: 188: 17.90		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		111929 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		K9JA46_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		118674 AIP_HUMAN (33-316): 2.17e-53: 180: 17.39		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	At
		646592 FKB42_ARATH (7-327): 6.66e-63: 205: 25.38		HS901_ARATH (10-724): 0: 999: 67.97
+	Ce
		220015 O45418_CAEEL (2-324): 1.82e-59: 198: 20.12		HSP90_CAEEL (8-724): 0: 976: 74.34
+	Hs
		972520 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		972530 FKBP4_HUMAN (2-327): 4.29e-73: 234: 23.33		Q6PK50_HUMAN (1-350): 0: 618: 99.71
+	Hs
		1053004 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		H90B4_HUMAN (25-596): 0: 639: 71.85
+	Hs
		1053029 FKBP8_HUMAN (1-319): 8.64e-60: 198: 23.80		Q6PK50_HUMAN (1-350): 0: 618: 99.71