HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: CSN4 (Q9BT78)
COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)
Gene: COPS4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	31973889, 16964240, 17079684, 18606781, 21145461, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 759 Hs			1 406
+	Hs
		1043547 CUL4B_HUMAN (10-759): 0: 927: 82.31		CSN4_HUMAN (1-406): 1.62e-167: 476: 100.00
+	Hs
		122005 CUL4A_HUMAN (1-759): 0: 963: 100.00		PSD12_HUMAN (7-392): 8.84e-116: 347: 19.76
+	Hs
		1042418 CUL3_HUMAN (32-759): 0: 814: 38.23		CSN4_HUMAN (1-406): 1.62e-167: 476: 100.00
+	At
		1226048 CUL4_ARATH (24-759): 0: 861: 57.40		CSN4_ARATH (17-391): 2.12e-122: 362: 49.61
+	Hs
		1041179 CUL1_HUMAN (59-759): 0: 745: 30.55		CSN4_HUMAN (1-406): 1.62e-167: 476: 100.00
+	At
		1226058 CUL3A_ARATH (36-759): 0: 853: 38.26		CSN4_ARATH (17-391): 2.12e-122: 362: 49.61
+	Hs
		1041454 CUL2_HUMAN (51-759): 0: 710: 27.00		CSN4_HUMAN (1-406): 1.62e-167: 476: 100.00
+	At
		1226052 CUL1_ARATH (57-759): 0: 744: 34.20		CSN4_ARATH (17-391): 2.12e-122: 362: 49.61
+	Hs
		1274036 CUL5_HUMAN (59-759): 0: 589: 24.94		CSN4_HUMAN (1-406): 1.62e-167: 476: 100.00
+	Sp
		142903 CUL1_SCHPO (62-759): 0: 680: 29.27		CSN4_SCHPO (79-380): 4.42e-74: 237: 24.05
+	Sp
		143480 CUL3_SCHPO (38-759): 0: 662: 32.15		CSN4_SCHPO (79-380): 4.42e-74: 237: 24.05
+	Sc
		1014846 CDC53_YEAST (52-759): 0: 561: 21.90		RPN5_YEAST (8-392): 1.62e-101: 310: 18.45