Protein: ABCB6
ATP-binding cassette sub-family B member 6 (ABC-type heme transporter ABCB6) (EC 7.6.2.5) (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (P-glycoprotein-related protein) (Ubiquitously-expressed mammalian ABC half transporter)

Gene: ABCB6
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9NP58

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005740 - mitochondrial envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1186235

CEA21
Cell adhesion molecule CEACAM21

2

1

High-throughput

0.705

High

418745

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

0

High-throughput

0.638

High

720636

GRPR
Gastrin-releasing peptide receptor

2

4

High-throughput

0.628

High

1445838

CLC2D
C-type lectin domain family 2 member D

2

6

High-throughput

0.628

High

1445841

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

3

High-throughput

0.618

High

596781

DPEP1
Dipeptidase 1

2

0

High-throughput

0.602

High

1391389

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.602

High

396998

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

124507

HAX1
HCLS1-associated protein X-1

1

3

High-throughput

0.536

High

182785

GP182
G-protein coupled receptor 182

1

15

High-throughput

0.536

High

260803

RAMP2
Receptor activity-modifying protein 2

1

3

High-throughput

0.536

High

260966

RAMP3
Receptor activity-modifying protein 3

1

3

High-throughput

0.536

High

575705

GPIX
Platelet glycoprotein IX

1

3

High-throughput

0.536

High

688632

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

8

High-throughput

0.536

High

700805

DMB
HLA class II histocompatibility antigen, DM beta chain

1

5

High-throughput

0.536

High

1086116

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.536

High

1098945

KLRD1
Natural killer cells antigen CD94

1

7

High-throughput

0.536

High

1286919

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.536

High

1415969

IFT27
Intraflagellar transport protein 27 homolog

1

7

High-throughput

0.536

High

1428914

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

3

High-throughput

0.536

High

1432419

TTYH1
Protein tweety homolog 1

1

4

High-throughput

0.536

High

1445835

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.536

High

1445839

PCDAC
Protocadherin alpha-12

1

5

High-throughput

0.536

High

139327

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

407218

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

488349

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.513

High

818839

TYRP2
L-dopachrome tautomerase

1

0

High-throughput

0.513

High

956108

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

1159239

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1239304

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.513

High

1324866

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1341192

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.513

High

1417259

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1429849

TOLIP
Toll-interacting protein

1

0

High-throughput

0.513

High

1434646

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1445836

MIOX
Inositol oxygenase

1

0

High-throughput

0.513

High

1445844

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.513

High

1364882

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

4

High-throughput

0.508

High

140445

SDCB1
Syntenin-1

1

1

Small-scale

0.501

High

1395908

ARL5B
ADP-ribosylation factor-like protein 5B

1

4

High-throughput

0.489

High

178406

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

189864

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

294366

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

508675

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

High-throughput

0.479

High

627575

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

6

High-throughput

0.479

High

765910

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

831471

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

989127

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

1124922

FLOT2
Flotillin-2

1

2

High-throughput

0.479

High

1229697

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1404779

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.479

High

1417482

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1433960

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1445837

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1445840

BCS1
Mitochondrial chaperone BCS1

1

3

High-throughput

0.479

High

1445842

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.479

High

1445843

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

378188

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

907847

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.458

High

1414937

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.458

High

190492

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.445

High

380153

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.445

High

538811

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

3

High-throughput

0.445

High

722629

CTR1
High affinity cationic amino acid transporter 1

1

4

High-throughput

0.445

High

869679

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

5

High-throughput

0.445

High

948938

CD81
CD81 antigen

1

6

High-throughput

0.445

High

1157201

S15A2
Solute carrier family 15 member 2

1

4

High-throughput

0.445

High

1334284

S38A9
Neutral amino acid transporter 9

1

1

High-throughput

0.445

High

1340568

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.445

High

1352576

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.445

High

1361317

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.445

High

1363457

S39A7
Zinc transporter SLC39A7

1

9

High-throughput

0.445

High

1407473

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

1255646

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

379577

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

1445834

S52A3
Solute carrier family 52, riboflavin transporter, member 3

1

0

High-throughput

0.426

High

709051

NEC1
Neuroendocrine convertase 1

1

0

High-throughput

0.279

Low

1213711

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

1243404

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

1286749

CLC14
C-type lectin domain family 14 member A

1

0

High-throughput

0.279

Low

1397320

CA074
UPF0739 protein C1orf74

1

0

High-throughput

0.279

Low

1420113

CHIA
Acidic mammalian chitinase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025