HitPredict

Interactor 1: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	36950384
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 763 Hs			1 261
+	Hs
		266986 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		201668 DYR1A_HUMAN (1-763): 0: 613: 100.00		MSI1H_HUMAN (2-95): 2.87e-22: 96: 26.60
+	Hs
		951958 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		1031320 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP4_HUMAN (2-101): 2.19e-20: 92.1: 18.00
+	Hs
		516508 DYR1A_HUMAN (1-763): 0: 613: 100.00		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		1043828 DYR1A_HUMAN (1-763): 0: 613: 100.00		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		647984 MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		267037 DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Sc
		376610 YAK1_YEAST (19-586): 3.53e-116: 371: 29.05		PABP_YEAST (2-98): 1.48e-20: 92.5: 22.68
+	Zm
		11850 A0A1D6FHK3_MAIZE (103-525): 7.64e-118: 362: 22.50		A0A1D6II08_MAIZE (6-256): 7.04e-21: 93.3: 15.94
+	Hs
		516362 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		625466 CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	At
		847172 AFC2_ARATH (141-481): 9.86e-54: 193: 32.70		SRC33_ARATH (5-254): 1.33e-21: 93: 29.20
+	Zm
		16139 A0A1D6JDK3_MAIZE (136-478): 9.83e-51: 193: 33.58		A0A1D6GKL8_MAIZE (13-87): 6.18e-21: 88: 38.67
+	At
		51037 A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76
+	At
		847175 AFC3_ARATH (129-483): 3.59e-56: 199: 32.90		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76