HitPredict

Interactor 1: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Interactor 2: GOLI (Q86XS8)
E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)
Gene: RNF130

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1447 Hs			1 419
+	Dm
		577386 PTC_DROME (48-1283): 0: 993: 38.23		GZL_DROME (16-415): 1.37e-64: 217: 19.90
+	Dm
		577370 PTC_DROME (48-1283): 0: 993: 38.23		HRD1_DROME (17-339): 2.95e-49: 178: 13.11
+	Hs
		167772 NPC1_HUMAN (59-1191): 0: 713: 19.74		RNF13_HUMAN (11-379): 6.47e-72: 232: 22.08
+	Hs
		167957 NPC1_HUMAN (59-1191): 0: 713: 19.74		SYVN1_HUMAN (17-312): 1.08e-56: 198: 14.38
+	Hs
		168073 NPC1_HUMAN (59-1191): 0: 713: 19.74		AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50
+	Hs
		1262022 DISP1_HUMAN (370-1383): 0: 596: 12.35		RN133_HUMAN (4-373): 1.75e-79: 251: 26.69
+	Hs
		1016006 SCAP_HUMAN (204-731): 2.22e-87: 314: 15.44		ZNRF4_HUMAN (6-375): 3.81e-59: 200: 18.95
+	Hs
		373137 HMDH_HUMAN (422-734): 7.48e-46: 181: 13.42		RN148_HUMAN (28-310): 2.43e-70: 226: 35.66
+	Hs
		373142 HMDH_HUMAN (422-734): 7.48e-46: 181: 13.42		ZNRF4_HUMAN (6-375): 3.81e-59: 200: 18.95
+	Hs
		373130 HMDH_HUMAN (422-734): 7.48e-46: 181: 13.42		SYVN1_HUMAN (17-312): 1.08e-56: 198: 14.38
+	Hs
		373164 HMDH_HUMAN (422-734): 7.48e-46: 181: 13.42		AMFR_HUMAN (2-346): 7.99e-45: 166: 13.50