Protein: HSF2
Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2)

Gene: HSF2
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q03933

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001162 - RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026325

HSF1
Heat shock factor protein 1

9

17

Small-scale

0.980

High

1044394

HSF4
Heat shock factor protein 4

2

17

High-throughput

0.811

High

964871

WDR5
WD repeat-containing protein 5

5

3

Small-scale

0.717

High

1044347

MTUS2
Microtubule-associated tumor suppressor candidate 2

4

2

High-throughput

0.698

High

789094

NUP62
Nuclear pore glycoprotein p62

3

4

Small-scale

0.673

High

336651

BAG4
BAG family molecular chaperone regulator 4

3

6

High-throughput

0.667

High

269178

HSF2B
Heat shock factor 2-binding protein

3

1

High-throughput

0.665

High

537013

HSP7C
Heat shock cognate 71 kDa protein

3

10

High-throughput

0.662

High

447742

TPM3
Tropomyosin alpha-3 chain

5

5

High-throughput

0.662

High

930854

HSP72
Heat shock-related 70 kDa protein 2

3

12

High-throughput

0.650

High

1044364

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

1

High-throughput

0.611

High

993512

UBC9
SUMO-conjugating enzyme UBC9

2

2

Small-scale

0.594

High

346969

BAG2
BAG family molecular chaperone regulator 2

3

2

High-throughput

0.593

High

1044369

CEP76
Centrosomal protein of 76 kDa

3

1

High-throughput

0.591

High

161869

IMPA2
Inositol monophosphatase 2

2

0

High-throughput

0.585

High

1044386

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1044398

DEOC
Deoxyribose-phosphate aldolase

2

0

High-throughput

0.580

High

1044358

WDR5B
WD repeat-containing protein 5B

2

3

High-throughput

0.574

High

1044388

HPBP1
Hsp70-binding protein 1

2

6

High-throughput

0.574

High

1044399

WASC3
WASH complex subunit 3

2

1

High-throughput

0.574

High

766084

PCGF2
Polycomb group RING finger protein 2

1

2

Small-scale

0.573

High

1044341

CUL3
Cullin-3

1

1

Small-scale

0.573

High

718548

CDC27
Cell division cycle protein 27 homolog

1

3

Small-scale

0.561

High

1044339

CDC20
Cell division cycle protein 20 homolog

1

6

Small-scale

0.561

High

1044395

FZR1
Fizzy-related protein homolog

1

6

Small-scale

0.561

High

1044382

TRI54
Tripartite motif-containing protein 54

1

3

High-throughput

0.541

High

248694

PEPL
Periplakin

1

3

High-throughput

0.536

High

402910

ANXA1
Annexin A1

1

3

High-throughput

0.536

High

445168

S10A6
Protein S100-A6

1

5

High-throughput

0.536

High

748643

DSG3
Desmoglein-3

1

2

High-throughput

0.536

High

787637

SPB5
Serpin B5

1

1

High-throughput

0.536

High

974928

TYB4
Thymosin beta-4

1

1

High-throughput

0.536

High

1044344

SRSF7
Serine/arginine-rich splicing factor 7

1

2

High-throughput

0.536

High

1044354

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

1

High-throughput

0.536

High

1044372

RAD50
DNA repair protein RAD50

1

5

High-throughput

0.536

High

1044377

LURA1
Leucine rich adaptor protein 1

1

1

High-throughput

0.536

High

1044380

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.536

High

1044391

CRNN
Cornulin

1

5

High-throughput

0.536

High

1044400

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.536

High

966216

1433G
14-3-3 protein gamma

1

6

High-throughput

0.515

High

1044373

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.515

High

328432

SCEL
Sciellin

1

0

High-throughput

0.513

High

457856

INVO
Involucrin

1

0

High-throughput

0.513

High

722779

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

775413

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.513

High

1032286

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1044337

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1044342

THOC5
THO complex subunit 5

1

0

High-throughput

0.513

High

1044367

INADL
InaD-like protein

1

0

High-throughput

0.513

High

1044370

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.513

High

1044343

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.493

High

1044368

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

284563

ECI2
Enoyl-CoA delta isomerase 2

1

1

High-throughput

0.489

High

1044363

LIPB2
Liprin-beta-2

1

1

High-throughput

0.489

High

1044371

EVPL
Envoplakin

1

4

High-throughput

0.489

High

1044389

ZNFX1
NFX1-type zinc finger-containing protein 1

1

2

High-throughput

0.489

High

207956

TET3
Methylcytosine dioxygenase TET3

1

2

High-throughput

0.479

High

316383

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

High-throughput

0.479

High

347655

BAG3
BAG family molecular chaperone regulator 3

1

6

High-throughput

0.479

High

364126

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

2

High-throughput

0.479

High

413671

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

611661

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.479

High

755886

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.479

High

1044338

EP300
Histone acetyltransferase p300

1

6

Small-scale

0.479

High

1044345

FX4L6
Forkhead box protein D4-like 6

1

1

High-throughput

0.479

High

1044356

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

2

High-throughput

0.479

High

1044362

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1044365

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1044376

PIWL1
Piwi-like protein 1

1

2

High-throughput

0.479

High

1044381

BAG1
BAG family molecular chaperone regulator 1

1

2

High-throughput

0.479

High

1044383

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

1

High-throughput

0.479

High

1044392

BAG5
BAG family molecular chaperone regulator 5

1

6

High-throughput

0.479

High

1044396

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1044401

RBM7
RNA-binding protein 7

1

3

High-throughput

0.479

High

1044350

Q5VU62
TPM3 protein

1

3

High-throughput

0.470

High

1040771

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.460

High

281495

FBX24
F-box only protein 24

1

0

High-throughput

0.458

High

947342

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

0

High-throughput

0.458

High

1044346

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.458

High

1044348

Q5T7U4
General transcription factor IIIC subunit 5

1

0

High-throughput

0.458

High

1044353

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1044359

DAA11
Dynein axonemal assembly factor 11

1

0

High-throughput

0.458

High

1044384

PIF1
ATP-dependent DNA helicase PIF1

1

0

High-throughput

0.458

High

1044397

DYN3
Dynamin-3

1

0

High-throughput

0.458

High

761643

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.457

High

116972

J3KPD3
RNA-binding protein 7

1

2

High-throughput

0.445

High

1044378

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

62362

A4FVC0
Protein argonaute-1

1

2

High-throughput

0.437

High

75665

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

160481

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.437

High

1044352

Q6FHN3
Nucleoside diphosphate kinase

1

3

High-throughput

0.437

High

1044357

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

1

High-throughput

0.437

High

1044366

HUS1B
Checkpoint protein HUS1B

1

1

High-throughput

0.437

High

1044374

Q93000
CHL1 protein

1

1

High-throughput

0.437

High

1044375

Q96BE0
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.437

High

1044379

Q96S08
Chromosome transmission fidelity protein 18 homolog

1

3

High-throughput

0.437

High

1044385

Q9HAV2
Heat shock transcription factor 1

1

5

High-throughput

0.437

High

1044387

WSB2
WD repeat and SOCS box-containing protein 2

1

6

High-throughput

0.437

High

69489

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

116345

H3BSK8
RB binding protein 6, ubiquitin ligase

1

1

High-throughput

0.407

High

609305

SAP3
Ganglioside GM2 activator

2

0

High-throughput

0.318

High

1044340

ASAH1
Acid ceramidase

2

0

High-throughput

0.318

High

582569

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.279

Low

907897

PLXA3
Plexin-A3

1

0

High-throughput

0.279

Low

1044349

OBSCN
Obscurin

1

0

High-throughput

0.279

Low

1044355

GBP6
Guanylate-binding protein 6

1

0

High-throughput

0.279

Low

1044360

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

1044390

SPRR3
Small proline-rich protein 3

1

0

High-throughput

0.279

Low

723660

CALCR
Calcitonin receptor

1

0

High-throughput

0.249

Low

1044351

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1044361

Q8IWP3
Kappa-type opioid receptor

1

0

High-throughput

0.249

Low

1044393

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025