Protein: ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 5.6.2.3) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA 5'-3' helicase XPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)

Gene: ERCC2
Organism: Homo sapiens
Interactions: 84
UniProt ID: P18074

Gene Ontology (top 5):
GO:0000439 - transcription factor TFIIH core complex
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001666 - response to hypoxia
GO:0001701 - in utero embryonic development
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

611658

MAT1
CDK-activating kinase assembly factor MAT1

7

3

Small-scale

0.964

High

611667

TF2H2
General transcription factor IIH subunit 2

7

4

Small-scale

0.961

High

611647

TF2H1
General transcription factor IIH subunit 1

5

2

Small-scale

0.928

High

611655

CDK7
Cyclin-dependent kinase 7

12

3

Small-scale

0.758

High

611639

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

9

2

Small-scale

0.754

High

611676

T2H2L
General transcription factor IIH subunit 2-like protein

1

4

High-throughput

0.740

High

611690

MMS19
MMS19 nucleotide excision repair protein homolog

6

4

Small-scale

0.734

High

611657

CCNH
Cyclin-H

4

2

Small-scale

0.694

High

302744

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

4

6

Small-scale

0.689

High

611701

CIA2B
Cytosolic iron-sulfur assembly component 2B

4

6

Small-scale

0.689

High

611644

ERCC5
DNA excision repair protein ERCC-5

2

3

Small-scale

0.639

High

413153

P53
Cellular tumor antigen p53

2

1

Small-scale

0.619

High

611640

XPA
DNA repair protein complementing XP-A cells

1

1

Small-scale

0.618

High

611668

TF2H3
General transcription factor IIH subunit 3

2

2

Small-scale

0.595

High

611680

TF2H5
General transcription factor IIH subunit 5

2

0

Small-scale

0.592

High

395455

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

611674

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

611638

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

132429

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.536

High

362738

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.513

High

611651

CETN2
Centrin-2

1

0

High-throughput

0.513

High

611652

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.513

High

611656

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.513

High

611682

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

519725

ANDR
Androgen receptor

1

2

Small-scale

0.501

High

611645

T2EA
General transcription factor IIE subunit 1

1

1

Small-scale

0.501

High

611686

TF2H4
General transcription factor IIH subunit 4

1

3

Small-scale

0.500

High

611653

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.493

High

611659

LMNB2
Lamin-B2

1

2

High-throughput

0.489

High

578372

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.484

High

611669

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

Small-scale

0.480

High

611699

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.480

High

174482

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.479

High

240698

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

259410

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

386435

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

425301

ISG15
Ubiquitin-like protein ISG15

1

2

Small-scale

0.479

High

587873

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

611642

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

611643

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

611646

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

611648

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

611650

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

611660

ERCC6
DNA excision repair protein ERCC-6

1

1

Small-scale

0.479

High

611661

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.479

High

611662

RAD51
DNA repair protein RAD51 homolog 1

1

3

Small-scale

0.479

High

611664

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

611666

CUL3
Cullin-3

1

3

High-throughput

0.479

High

611670

BRD3
Bromodomain-containing protein 3

1

3

High-throughput

0.479

High

611672

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

4

High-throughput

0.479

High

611675

BRDT
Bromodomain testis-specific protein

1

4

High-throughput

0.479

High

611677

Q6PK50
HSP90AB1 protein

1

4

High-throughput

0.479

High

611679

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

611681

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

611685

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

611687

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

611688

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

611689

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.479

High

611691

Q9BPW0
Serine/threonine-protein phosphatase

1

1

High-throughput

0.479

High

611692

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

611694

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

611695

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

172456

XPO1
Exportin-1

1

0

High-throughput

0.458

High

371111

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.458

High

411319

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

611641

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

611649

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.458

High

611654

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

611663

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

611665

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

611671

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

611673

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

611678

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

Small-scale

0.458

High

611684

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

611693

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

611696

PIDD1
p53-induced death domain-containing protein 1

1

0

Small-scale

0.458

High

258754

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.445

High

76510

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.437

High

611698

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

611683

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

105292

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

611697

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.232

Low

611700

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.232

Low

611702

NPTN
Neuroplastin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025