HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.595

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 347
+	Hs
		1045408 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1045423 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Rn
		192738 SPTN1_RAT (1-2472): 0: 713: 98.58		SRBS2_RAT (243-342): 7.4e-12: 68.5: 21.57
+	Hs
		924555 SPTN1_HUMAN (1-2472): 0: 714: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		434800 SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20		SRBS2_MOUSE (243-342): 8.22e-12: 68.5: 20.59
+	Hs
		963325 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1052202 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		963409 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		PACN1_HUMAN (6-342): 5.44e-34: 131: 14.90
+	Hs
		1068712 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		3BP1_HUMAN (6-252): 2.26e-38: 146: 17.63
+	Hs
		974139 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		PACN1_HUMAN (6-342): 5.44e-34: 131: 14.90
+	Hs
		963335 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		924482 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		974083 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		924491 DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		924586 PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		1113251 ACTN1_MOUSE (1862-2210): 1.97e-10: 68.6: 21.99		SRBS2_MOUSE (243-342): 8.22e-12: 68.5: 20.59
+	Hs
		521521 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		298946 ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15
+	Hs
		211557 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		211443 ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15		SRBS2_HUMAN (291-344): 2.01e-10: 64.3: 48.15