Protein: RN169
E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)

Gene: RN169, RNF169
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q8NCN4

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508290

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

15

Small-scale

0.940

High

1115827

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

9

4

Small-scale

0.758

High

980933

H2B1C
Histone H2B type 1-C/E/F/G/I

2

7

High-throughput

0.754

High

998558

H31
Histone H3.1

2

8

High-throughput

0.754

High

964678

DCAF7
DDB1- and CUL4-associated factor 7

4

4

Small-scale

0.694

High

1335882

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

11

Small-scale

0.684

High

1335899

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

3

4

Small-scale

0.667

High

419092

H2A1B
Histone H2A type 1-B/E

1

9

Small-scale

0.647

High

502061

H2AZ
Histone H2A.Z

1

11

Small-scale

0.647

High

909352

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.647

High

1232698

H2A2A
Histone H2A type 2-A

1

9

Small-scale

0.647

High

1335897

KLDC2
Kelch domain-containing protein 2

2

1

High-throughput

0.628

High

883617

CENPA
Histone H3-like centromeric protein A

1

8

High-throughput

0.618

High

1017033

H33
Histone H3.3

1

8

High-throughput

0.618

High

1162838

H2A2C
Histone H2A type 2-C

1

9

Small-scale

0.618

High

1163069

H2B2E
Histone H2B type 2-E

1

7

Small-scale

0.618

High

1119758

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

10

High-throughput

0.611

High

1335884

HOOK2
Protein Hook homolog 2

2

11

High-throughput

0.606

High

372602

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

799306

BRCA1
Breast cancer type 1 susceptibility protein

2

18

High-throughput

0.584

High

269298

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1335875

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.580

High

396534

ESR1
Estrogen receptor

2

9

High-throughput

0.571

High

1309664

ARHGJ
Rho guanine nucleotide exchange factor 19

2

7

High-throughput

0.571

High

1063444

GOGA2
Golgin subfamily A member 2

2

10

High-throughput

0.553

High

601771

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

881675

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.513

High

1335889

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

706224

S10A2
Protein S100-A2

1

11

High-throughput

0.489

High

1013313

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1335879

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.489

High

1335878

PIBF1
Progesterone-induced-blocking factor 1

1

3

High-throughput

0.481

High

191001

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

254392

CC14B
Dual specificity protein phosphatase CDC14B

1

6

High-throughput

0.479

High

260187

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

323492

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

High-throughput

0.479

High

487544

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.479

High

634536

LMNB1
Lamin-B1

1

17

High-throughput

0.479

High

658281

RS3
Small ribosomal subunit protein uS3

1

5

Small-scale

0.479

High

714276

PML
Protein PML

1

20

High-throughput

0.479

High

786732

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

High-throughput

0.479

High

867282

CAPZB
F-actin-capping protein subunit beta

1

1

Small-scale

0.479

High

915133

CAZA1
F-actin-capping protein subunit alpha-1

1

1

Small-scale

0.479

High

980005

H4
Histone H4

1

5

High-throughput

0.479

High

997432

TBB4B
Tubulin beta-4B chain

1

12

Small-scale

0.479

High

1027597

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

10

Small-scale

0.479

High

1045535

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1088916

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

1097433

CBX3
Chromobox protein homolog 3

1

7

High-throughput

0.479

High

1113728

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1129655

MDC1
Mediator of DNA damage checkpoint protein 1

1

9

High-throughput

0.479

High

1276496

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1313265

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1314313

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1335876

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.479

High

1335880

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1335881

RAD50
DNA repair protein RAD50

1

11

Small-scale

0.479

High

1335893

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1335894

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1194560

Q4G0R1
PIBF1 protein

1

3

High-throughput

0.470

High

262102

NBN
Nibrin

1

0

Small-scale

0.458

High

697183

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

799988

COIL
Coilin

1

0

High-throughput

0.458

High

892901

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

1058147

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1157821

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1244799

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1335896

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

1335898

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

114566

H0YKB7
Interleukin 16

1

9

High-throughput

0.445

High

207597

DHX15
ATP-dependent RNA helicase DHX15

1

6

Small-scale

0.445

High

321597

PRP6
Pre-mRNA-processing factor 6

1

3

Small-scale

0.445

High

467554

4F2
Amino acid transporter heavy chain SLC3A2

1

1

Small-scale

0.445

High

547651

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

Small-scale

0.445

High

755756

MCM4
DNA replication licensing factor MCM4

1

1

Small-scale

0.445

High

991370

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.445

High

1004847

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

Small-scale

0.445

High

1065308

SSRP1
FACT complex subunit SSRP1

1

6

Small-scale

0.445

High

1144712

PWP2
Periodic tryptophan protein 2 homolog

1

3

Small-scale

0.445

High

1168843

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

Small-scale

0.445

High

1179329

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

Small-scale

0.445

High

1219301

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

Small-scale

0.445

High

1286768

KAISO
Transcriptional regulator Kaiso

1

16

Small-scale

0.445

High

1315642

RN168
E3 ubiquitin-protein ligase RNF168

1

1

Small-scale

0.445

High

1335877

P66B
Transcriptional repressor p66-beta

1

1

Small-scale

0.445

High

1335885

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

5

Small-scale

0.445

High

1335887

KIFC1
Kinesin-like protein KIFC1

1

5

Small-scale

0.445

High

1335888

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

2

Small-scale

0.445

High

1335892

SAE2
SUMO-activating enzyme subunit 2

1

2

Small-scale

0.445

High

1335895

PLAP
Phospholipase A-2-activating protein

1

6

Small-scale

0.445

High

106295

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

272970

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

Small-scale

0.426

High

430631

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.426

High

608159

PYRG1
CTP synthase 1

1

0

Small-scale

0.426

High

1131777

LBR
Delta(14)-sterol reductase LBR

1

0

Small-scale

0.426

High

1213121

BEND3
BEN domain-containing protein 3

1

0

Small-scale

0.426

High

1335883

INT12
Integrator complex subunit 12

1

0

Small-scale

0.426

High

1335886

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.426

High

1335890

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

0

Small-scale

0.426

High

1335891

BCD1
Box C/D snoRNA protein 1

1

0

Small-scale

0.426

High

1038914

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025