HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 669
+	Hs
		1045423 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		1045537 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02
+	Hs
		1045471 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		1045418 SPTN1_HUMAN (1-2472): 0: 714: 100.00		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		148786 SPTN1_HUMAN (1-2472): 0: 714: 100.00		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		522612 SPTN1_HUMAN (1-2472): 0: 714: 100.00		MYH7_HUMAN (140-540): 9.01e-09: 61.2: 9.45
+	Hs
		360629 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SMCA2_HUMAN (18-531): 1.58e-34: 143: 13.60
+	Hs
		360630 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Mm
		93541 SPTA1_MOUSE (1-2472): 2.17e-161: 558: 54.20		DESP_MOUSE (337-641): 2.9e-11: 69.3: 18.65
+	Hs
		360644 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Dm
		404218 ACTN_DROME (1864-2470): 1.19e-77: 281: 30.27		MYSA_DROME (329-654): 6.59e-14: 77.9: 14.65
+	Hs
		164647 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		148142 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		963335 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		963431 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02
+	Hs
		963324 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		963381 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		148690 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Mm
		93578 PLEC_MOUSE (1-1250): 7.03e-38: 159: 10.80		DESP_MOUSE (337-641): 2.9e-11: 69.3: 18.65
+	Hs
		1059229 GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52