Protein: ACTN3
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)

Gene: ACTN3
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q08043

Gene Ontology (top 5):
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

224699

ACTN4
Alpha-actinin-4

4

14

High-throughput

0.885

High

555670

ACTN1
Alpha-actinin-1

4

14

High-throughput

0.885

High

123242

PDLI1
PDZ and LIM domain protein 1

3

20

High-throughput

0.861

High

1061508

ACTN3
Alpha-actinin-3

3

14

High-throughput

0.845

High

773732

ACTN2
Alpha-actinin-2

2

14

Small-scale

0.819

High

1061512

PTK6
Protein-tyrosine kinase 6

2

9

High-throughput

0.783

High

1061536

MILK2
MICAL-like protein 2

2

16

High-throughput

0.783

High

1061560

MYOZ1
Myozenin-1

2

7

High-throughput

0.783

High

1061541

TITIN
Titin

1

20

High-throughput

0.698

High

1061566

LHX3
LIM/homeobox protein Lhx3

2

0

High-throughput

0.655

High

1061511

TRAF1
TNF receptor-associated factor 1

3

5

High-throughput

0.654

High

1034564

AK17A
A-kinase anchor protein 17A

2

3

High-throughput

0.628

High

1061537

MILK1
MICAL-like protein 1

1

16

High-throughput

0.618

High

1061557

PKHG2
Pleckstrin homology domain-containing family G member 2

2

13

High-throughput

0.613

High

169525

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

6

High-throughput

0.606

High

349969

SNAI1
Zinc finger protein SNAI1

2

5

High-throughput

0.606

High

1061544

ASB9
Ankyrin repeat and SOCS box protein 9

2

20

High-throughput

0.606

High

1061548

PKP2
Plakophilin-2

2

9

High-throughput

0.606

High

1061553

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

1

High-throughput

0.606

High

1061559

SYP2L
Synaptopodin 2-like protein

2

20

High-throughput

0.606

High

1061565

MYOTI
Myotilin

2

14

High-throughput

0.606

High

441421

CHLE
Cholinesterase

2

0

High-throughput

0.602

High

156447

ACPM
Acyl carrier protein, mitochondrial

2

0

High-throughput

0.580

High

269183

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

350289

DDAH2
Putative hydrolase DDAH2

2

0

High-throughput

0.580

High

425903

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

2

0

High-throughput

0.580

High

876460

K2C6C
Keratin, type II cytoskeletal 6C

2

0

High-throughput

0.580

High

1061517

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

1061571

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

1061552

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

2

20

High-throughput

0.574

High

1061523

CDC73
Parafibromin

1

3

Small-scale

0.573

High

71798

CMA1B
Ciliary microtubule associated protein 1B

2

1

High-throughput

0.553

High

288396

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

5

High-throughput

0.553

High

771556

HXD12
Homeobox protein Hox-D12

2

1

High-throughput

0.553

High

848370

MAGA6
Melanoma-associated antigen 6

2

1

High-throughput

0.553

High

1007912

PO6F2
POU domain, class 6, transcription factor 2

2

2

High-throughput

0.553

High

1061513

TRI29
Tripartite motif-containing protein 29

2

4

High-throughput

0.553

High

1061515

RTP5
Receptor-transporting protein 5

2

1

High-throughput

0.553

High

1061522

PPR18
Phostensin

2

5

High-throughput

0.553

High

1061528

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.553

High

1061540

LNX1
E3 ubiquitin-protein ligase LNX

2

17

High-throughput

0.553

High

1061550

ZN426
Zinc finger protein 426

2

2

High-throughput

0.553

High

1061551

GLIS2
Zinc finger protein GLIS2

2

4

High-throughput

0.553

High

1061564

ZN219
Zinc finger protein 219

2

3

High-throughput

0.549

High

349051

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.536

High

563677

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

1040776

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.536

High

1061521

K1C39
Keratin, type I cytoskeletal 39

1

2

High-throughput

0.536

High

1061531

TSN33
Tetraspanin-33

1

4

High-throughput

0.536

High

277010

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.513

High

1061534

GRM2A
GRAM domain-containing protein 2A

1

0

High-throughput

0.513

High

1061546

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.513

High

1061547

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.513

High

1061532

GPBP1
Vasculin

1

0

High-throughput

0.493

High

1061538

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.489

High

1061549

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

2

High-throughput

0.489

High

1061569

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.489

High

302163

NEBL
Nebulette

1

18

High-throughput

0.481

High

799032

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.481

High

1048832

REL
Proto-oncogene c-Rel

1

7

High-throughput

0.481

High

1061510

TRAF2
TNF receptor-associated factor 2

1

7

High-throughput

0.481

High

1061527

RN111
E3 ubiquitin-protein ligase Arkadia

1

3

High-throughput

0.481

High

1061530

MYPN
Myopalladin

1

19

Small-scale

0.481

High

1061539

KCTD6
BTB/POZ domain-containing protein KCTD6

1

16

High-throughput

0.481

High

1061563

ABI3
ABI gene family member 3

1

14

High-throughput

0.481

High

1061567

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.481

High

157282

CTRO
Citron Rho-interacting kinase

1

15

High-throughput

0.479

High

222971

PRC1
Protein regulator of cytokinesis 1

1

15

High-throughput

0.479

High

400710

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

1054574

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.479

High

1061514

SCRIB
Protein scribble homolog

1

13

Small-scale

0.479

High

1061516

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1061543

CHM4C
Charged multivesicular body protein 4c

1

18

High-throughput

0.479

High

1061556

CHM4B
Charged multivesicular body protein 4b

1

18

High-throughput

0.479

High

1061558

ECT2
Protein ECT2

1

15

High-throughput

0.479

High

1061561

ANLN
Anillin

1

8

High-throughput

0.479

High

60234

A2RRN7
CADPS protein

1

2

High-throughput

0.470

High

482454

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.458

High

551005

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

849332

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

990141

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.445

High

1061509

MFGM
Lactadherin

1

3

High-throughput

0.445

High

1061525

CA094
Uncharacterized protein C1orf94

1

1

High-throughput

0.439

High

1061545

DUX5
Double homeobox protein 5

1

8

High-throughput

0.439

High

330898

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.437

High

1061570

SNX8
Sorting nexin-8

1

0

High-throughput

0.426

High

228410

DUX1
Double homeobox protein 1

1

7

High-throughput

0.417

High

1061526

DUX4C
Double homeobox protein 4C

1

10

High-throughput

0.417

High

1061542

ESR2
Estrogen receptor beta

1

13

High-throughput

0.407

High

1061568

RT23
Small ribosomal subunit protein mS23

1

1

High-throughput

0.407

High

686698

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

843123

CXCL5
C-X-C motif chemokine 5

2

0

High-throughput

0.316

High

1006239

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.316

High

1061519

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

1061520

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.316

High

1061524

ZN343
Zinc finger protein 343

2

0

High-throughput

0.316

High

1061533

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1061555

CMIP1
Ciliary microtubule inner protein 1

2

0

High-throughput

0.316

High

403081

REL2
Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

1061518

LACB2
Endoribonuclease LACTB2

1

0

High-throughput

0.279

Low

1061529

CE024
UPF0461 protein C5orf24

1

0

High-throughput

0.279

Low

1061535

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

1061554

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

889920

VEGFB
Vascular endothelial growth factor B

1

0

High-throughput

0.232

Low

1061562

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025