HitPredict

Interactor 1: UBE4A (Q14139)
Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)
Gene: UBE4A

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	U-box~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1066 Hs			1 147
+	Hs
		849328 UBE4A_HUMAN (1-1066): 0: 1352: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919726 UBE4A_HUMAN (1-1066): 0: 1352: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895793 UBE4A_HUMAN (1-1066): 0: 1352: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		305165 UBE4B_HUMAN (145-1061): 0: 846: 25.50		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		305164 UBE4B_HUMAN (145-1061): 0: 846: 25.50		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Sc
		549827 UFD2_YEAST (148-1063): 0: 773: 22.81		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	Zm
		31012 A0A1D6KE36_MAIZE (955-1059): 3.31e-35: 145: 28.33		B4FC97_MAIZE (1-147): 1.78e-83: 243: 79.59
+	Ce
		105587 G5ECY6_CAEEL (832-1065): 7.13e-30: 121: 17.87		UBC2_CAEEL (1-147): 1.59e-82: 240: 92.52
+	At
		715129 CHIP_ARATH (941-1063): 2.11e-29: 120: 20.93		UBC8_ARATH (1-147): 7.07e-83: 241: 80.27
+	At
		715145 CHIP_ARATH (941-1063): 2.11e-29: 120: 20.93		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	At
		715154 CHIP_ARATH (941-1063): 2.11e-29: 120: 20.93		UBC10_ARATH (1-147): 1.22e-82: 241: 79.59
+	Os
		1014691 PUB75_ORYSJ (954-1064): 4.21e-28: 121: 22.03		UBC5B_ORYSJ (1-147): 3.18e-82: 239: 79.59
+	Hs
		849489 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		919907 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		895956 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		1297379 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		1282365 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		851908 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Zm
		14055 A0A1D6LII0_MAIZE (818-1063): 3.81e-31: 126: 19.52		A0A1D6G0U5_MAIZE (1-113): 3.26e-67: 202: 82.30
+	Hs
		896567 CHIP_HUMAN (973-1060): 2.49e-27: 115: 33.71		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53