Protein: NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)

Gene: NFAC1, NFATC1
Organism: Homo sapiens
Interactions: 171
UniProt ID: O95644

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003180 - aortic valve morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

340807

JUN
Transcription factor Jun

3

20

High-throughput

0.861

High

340883

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

3

18

Small-scale

0.827

High

340935

FOXP3
Forkhead box protein P3

3

20

Small-scale

0.827

High

340818

CREB1
Cyclic AMP-responsive element-binding protein 1

2

4

High-throughput

0.802

High

340800

FOS
Protein c-Fos

2

20

High-throughput

0.789

High

340798

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

18

Small-scale

0.737

High

340817

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

20

High-throughput

0.715

High

340824

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

8

High-throughput

0.715

High

340876

PP2BA
Protein phosphatase 3 catalytic subunit alpha

4

13

Small-scale

0.708

High

340877

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.697

High

340821

JUND
Transcription factor JunD

1

20

High-throughput

0.691

High

340825

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

High-throughput

0.691

High

340845

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

4

10

High-throughput

0.691

High

271792

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.628

High

340864

CANB1
Calcineurin subunit B type 1

2

3

High-throughput

0.628

High

340904

LRC28
Leucine-rich repeat-containing protein 28

2

2

High-throughput

0.628

High

340906

ARMC8
Armadillo repeat-containing protein 8

2

10

High-throughput

0.628

High

340944

KTU
Protein kintoun

2

1

High-throughput

0.628

High

340951

MKLN1
Muskelin

2

7

High-throughput

0.628

High

340900

A20A1
Ankyrin repeat domain-containing protein 20A1

1

10

High-throughput

0.618

High

340816

ETS1
Protein C-ets-1

1

16

Small-scale

0.618

High

340820

JUNB
Transcription factor JunB

1

20

High-throughput

0.618

High

340822

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

20

High-throughput

0.618

High

340835

ELF1
ETS-related transcription factor Elf-1

1

18

Small-scale

0.618

High

340867

FOXK1
Forkhead box protein K1

1

15

High-throughput

0.618

High

340868

FOXK2
Forkhead box protein K2

1

16

High-throughput

0.618

High

340873

REL
Proto-oncogene c-Rel

1

19

Small-scale

0.618

High

340805

P53
Cellular tumor antigen p53

2

10

High-throughput

0.611

High

340854

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

13

High-throughput

0.611

High

340875

SUH
Recombining binding protein suppressor of hairless

2

2

High-throughput

0.611

High

340914

SMRC2
SWI/SNF complex subunit SMARCC2

2

20

High-throughput

0.611

High

340918

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.611

High

340823

EGR1
Early growth response protein 1

2

8

Small-scale

0.608

High

340926

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.602

High

340861

IL2
Interleukin-2

2

6

Small-scale

0.584

High

340920

CBP
CREB-binding protein

2

20

Small-scale

0.584

High

340809

PARP1
Poly [ADP-ribose] polymerase 1

1

8

Small-scale

0.561

High

340812

PIM1
Serine/threonine-protein kinase pim-1

1

8

Small-scale

0.561

High

340953

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.561

High

340866

UBC9
SUMO-conjugating enzyme UBC9

1

9

Small-scale

0.552

High

185317

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

Small-scale

0.536

High

243495

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

13

High-throughput

0.536

High

331530

KIF4A
Chromosome-associated kinesin KIF4A

1

5

High-throughput

0.536

High

333905

SMC2
Structural maintenance of chromosomes protein 2

1

3

High-throughput

0.536

High

340819

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

340826

H2A1D
Histone H2A type 1-D

1

4

High-throughput

0.536

High

340833

HXA10
Homeobox protein Hox-A10

1

2

High-throughput

0.536

High

340840

CUX1
Homeobox protein cut-like 1

1

10

High-throughput

0.536

High

340844

RECQ1
ATP-dependent DNA helicase Q1

1

8

High-throughput

0.536

High

340853

BLK
Tyrosine-protein kinase Blk

1

10

High-throughput

0.536

High

340857

HMGA2
High mobility group protein HMGI-C

1

2

High-throughput

0.536

High

340860

PRD15
PR domain zinc finger protein 15

1

1

High-throughput

0.536

High

340862

ISL1
Insulin gene enhancer protein ISL-1

1

11

High-throughput

0.536

High

340863

H2B1C
Histone H2B type 1-C/E/F/G/I

1

18

High-throughput

0.536

High

340878

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.536

High

340886

ZMYM3
Zinc finger MYM-type protein 3

1

3

High-throughput

0.536

High

340888

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.536

High

340891

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.536

High

340893

H31T
Histone H3.1t

1

7

High-throughput

0.536

High

340894

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.536

High

340899

BEND3
BEN domain-containing protein 3

1

1

High-throughput

0.536

High

340917

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.536

High

340925

H2B1A
Histone H2B type 1-A

1

18

High-throughput

0.536

High

340929

CANB2
Calcineurin subunit B type 2

1

3

High-throughput

0.536

High

340932

NEB2
Neurabin-2

1

7

High-throughput

0.536

High

340938

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.536

High

340939

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.536

High

340947

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.536

High

340952

SMC3
Structural maintenance of chromosomes protein 3

1

3

High-throughput

0.536

High

340879

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.513

High

340896

FWCH1
FLYWCH-type zinc finger-containing protein 1

1

0

High-throughput

0.513

High

340898

FRPD1
FERM and PDZ domain-containing protein 1

1

0

High-throughput

0.513

High

340948

SHPK
Sedoheptulokinase

1

0

High-throughput

0.513

High

340811

EGR2
E3 SUMO-protein ligase EGR2

1

8

Small-scale

0.501

High

340828

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

340889

IMB1
Importin subunit beta-1

1

6

Small-scale

0.501

High

340903

TBA1A
Tubulin alpha-1A chain

1

17

Small-scale

0.501

High

340921

KAT2B
Histone acetyltransferase KAT2B

1

10

Small-scale

0.501

High

340834

HXC13
Homeobox protein Hox-C13

1

7

High-throughput

0.500

High

340905

LRC33
Transforming growth factor beta activator LRRC33

1

1

High-throughput

0.489

High

297385

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.481

High

154596

ARI1A
AT-rich interactive domain-containing protein 1A

1

17

High-throughput

0.479

High

163027

CHK1
Serine/threonine-protein kinase Chk1

1

3

High-throughput

0.479

High

209410

SERA
D-3-phosphoglycerate dehydrogenase

1

8

High-throughput

0.479

High

230862

ORC5
Origin recognition complex subunit 5

1

4

High-throughput

0.479

High

340799

ACL6A
Actin-like protein 6A

1

10

High-throughput

0.479

High

340801

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

340802

TNFA
Tumor necrosis factor

1

16

Small-scale

0.479

High

340803

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

340804

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

340806

IL4
Interleukin-4

1

2

Small-scale

0.479

High

340808

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

Small-scale

0.479

High

340810

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

340813

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

340814

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

340827

KS6B1
Ribosomal protein S6 kinase beta-1

1

11

Small-scale

0.479

High

340829

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

340830

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.479

High

340831

PML
Protein PML

1

9

Small-scale

0.479

High

340836

RFC4
Replication factor C subunit 4

1

6

High-throughput

0.479

High

340837

RFC2
Replication factor C subunit 2

1

6

High-throughput

0.479

High

340838

HXD13
Homeobox protein Hox-D13

1

3

High-throughput

0.479

High

340839

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

340842

RFC5
Replication factor C subunit 5

1

6

High-throughput

0.479

High

340843

CATK
Cathepsin K

1

3

Small-scale

0.479

High

340846

KC1A
Casein kinase I isoform alpha

1

10

High-throughput

0.479

High

340847

KC1D
Casein kinase I isoform delta

1

10

High-throughput

0.479

High

340850

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

340851

DNLI3
DNA ligase 3

1

1

High-throughput

0.479

High

340852

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.479

High

340855

KS6A3
Ribosomal protein S6 kinase alpha-3

1

8

Small-scale

0.479

High

340859

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.479

High

340865

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

340869

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

340870

SATB1
DNA-binding protein SATB1

1

1

High-throughput

0.479

High

340871

IRF8
Interferon regulatory factor 8

1

20

Small-scale

0.479

High

340874

EGR4
Early growth response protein 4

1

10

Small-scale

0.479

High

340880

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

340882

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.479

High

340884

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

340885

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.479

High

340887

HLTF
Helicase-like transcription factor

1

16

High-throughput

0.479

High

340890

IRF4
Interferon regulatory factor 4

1

20

Small-scale

0.479

High

340892

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

340897

DCAF6
DDB1- and CUL4-associated factor 6

1

7

High-throughput

0.479

High

340901

NIPBL
Nipped-B-like protein

1

11

High-throughput

0.479

High

340902

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

340907

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

Small-scale

0.479

High

340908

RPTOR
Regulatory-associated protein of mTOR

1

12

High-throughput

0.479

High

340910

KC1AL
Casein kinase I isoform alpha-like

1

14

High-throughput

0.479

High

340911

SCAI
Protein SCAI

1

1

High-throughput

0.479

High

340913

WDR48
WD repeat-containing protein 48

1

11

High-throughput

0.479

High

340915

NEK7
Serine/threonine-protein kinase Nek7

1

10

High-throughput

0.479

High

340919

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

340922

SMRC1
SWI/SNF complex subunit SMARCC1

1

14

High-throughput

0.479

High

340923

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

9

High-throughput

0.479

High

340924

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

12

High-throughput

0.479

High

340927

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

6

High-throughput

0.479

High

340928

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

18

High-throughput

0.479

High

340930

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

340931

RANB9
Ran-binding protein 9

1

13

High-throughput

0.479

High

340933

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

340936

BC11B
B-cell lymphoma/leukemia 11B

1

2

High-throughput

0.479

High

340941

NEK6
Serine/threonine-protein kinase Nek6

1

11

High-throughput

0.479

High

340942

SYSM
Serine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

340945

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.479

High

340949

LEF1
Lymphoid enhancer-binding factor 1

1

11

High-throughput

0.479

High

340950

IKZF2
Zinc finger protein Helios

1

6

High-throughput

0.479

High

340954

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

340841

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

340881

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.458

High

340895

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

340937

GZF1
GDNF-inducible zinc finger protein 1

1

0

Small-scale

0.458

High

340940

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

340943

ZBT40
Zinc finger and BTB domain-containing protein 40

1

0

High-throughput

0.458

High

340946

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.458

High

340955

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

340856

JAK3
Tyrosine-protein kinase JAK3

1

17

Small-scale

0.445

High

105027

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

340815

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

3

High-throughput

0.437

High

340832

CD40L
CD40 ligand

1

16

Small-scale

0.437

High

340848

CX3C1
CX3C chemokine receptor 1

1

8

Small-scale

0.437

High

340849

EFTU
Elongation factor Tu, mitochondrial

1

8

High-throughput

0.437

High

340909

LRC47
Leucine-rich repeat-containing protein 47

1

4

High-throughput

0.437

High

340912

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.437

High

276233

SEM7A
Semaphorin-7A

2

0

High-throughput

0.328

High

340858

HMCS2
Hydroxymethylglutaryl-CoA synthase, mitochondrial

2

0

High-throughput

0.328

High

340872

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

0

High-throughput

0.328

High

340916

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

340934

TR61B
tRNA

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025