HitPredict

Interactor 1: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Interactor 2: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	28514442, 16628223, 33961781, 15212761, 32203420, 35271311
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ArfGap~PH, GIT_SHD~RhoGEF67_u2
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 759
+	Hs
		1049747 ARHG7_HUMAN (1-803): 0: 654: 100.00		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Hs
		1050107 ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48		GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00
+	Mm
		1322343 ARHG7_MOUSE (1-797): 0: 570: 91.09		GIT2_MOUSE (1-759): 5.02e-146: 446: 83.00
+	Mm
		1148433 ARHG7_MOUSE (1-797): 0: 570: 91.09		GIT1_MOUSE (1-758): 1.06e-139: 431: 63.43
+	Hs
		1066061 ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Gg
		1141020 ARHG6_CHICK (1-796): 4.88e-155: 472: 53.10		Q9DG15_CHICK (1-758): 1.05e-140: 433: 64.96
+	Mm
		1148429 ARHG6_MOUSE (1-762): 2.16e-155: 473: 53.57		GIT1_MOUSE (1-758): 1.06e-139: 431: 63.43
+	Rn
		223056 ARHG7_RAT (180-802): 6.24e-133: 411: 83.97		GIT1_RAT (1-758): 5.37e-138: 427: 63.43
+	Hs
		161301 VAV_HUMAN (1-778): 3.84e-111: 360: 16.96		MYPT1_HUMAN (94-670): 7.76e-54: 203: 10.75
+	Dm
		115754 M9PGB1_DROME (183-755): 1.19e-86: 296: 33.79		GIT_DROME (9-613): 6.41e-76: 261: 35.36
+	Dm
		1279243 Q9VIN1_DROME (183-755): 3.75e-86: 289: 33.79		GIT_DROME (9-613): 6.41e-76: 261: 35.36
+	Hs
		1021479 FARP1_HUMAN (225-625): 4.7e-96: 324: 21.36		ANK3_HUMAN (95-437): 2.74e-48: 187: 12.75
+	Hs
		1273297 ARHG2_HUMAN (62-801): 1.23e-80: 280: 13.33		ASAP1_HUMAN (3-656): 2.66e-63: 231: 15.57
+	Hs
		965179 FARP1_HUMAN (225-625): 4.7e-96: 324: 21.36		ANK2_HUMAN (108-437): 3.9e-45: 177: 13.13
+	Hs
		50548 PKHG3_HUMAN (245-582): 9.71e-84: 292: 23.70		POTEI_HUMAN (82-665): 5.17e-54: 203: 13.34
+	Mm
		1002014 TRIO_MOUSE (16-803): 6.77e-71: 256: 13.57		AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00
+	Dm
		1214884 Q9VIN1_DROME (183-755): 3.75e-86: 289: 33.79		Q8IQN4_DROME (96-626): 7.15e-54: 203: 12.81
+	Mm
		57843 KALRN_MOUSE (34-664): 3.16e-70: 255: 14.55		AGAP2_MOUSE (3-224): 1.24e-64: 236: 32.00
+	Hs
		166988 ARHG2_HUMAN (62-801): 1.23e-80: 280: 13.33		ANR28_HUMAN (204-531): 7.26e-32: 135: 9.09
+	Hs
		167038 PKHG1_HUMAN (242-759): 1.95e-78: 278: 19.82		ANR28_HUMAN (204-531): 7.26e-32: 135: 9.09