Protein: NOTC3
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]

Gene: NOTC3, NOTCH3
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q9UM47

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0005112 - Notch binding
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987018

SUH
Recombining binding protein suppressor of hairless

5

9

Small-scale

0.929

High

1347419

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

11

High-throughput

0.871

High

546493

INGR1
Interferon gamma receptor 1

2

1

High-throughput

0.811

High

1166910

DLK2
Protein delta homolog 2

2

19

High-throughput

0.811

High

1237561

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

3

14

High-throughput

0.770

High

944134

JAG1
Protein jagged-1

2

18

Small-scale

0.768

High

167042

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

16

High-throughput

0.698

High

1316311

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

20

High-throughput

0.698

High

1357250

NOTC3
Neurogenic locus notch homolog protein 3

1

19

Small-scale

0.692

High

225166

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

20

High-throughput

0.691

High

533105

PRG2
Bone marrow proteoglycan

1

11

High-throughput

0.691

High

804372

NOTC1
Neurogenic locus notch homolog protein 1

1

18

High-throughput

0.691

High

980576

NOTC2
Neurogenic locus notch homolog protein 2

1

19

High-throughput

0.691

High

1357254

ST14
Suppressor of tumorigenicity 14 protein

1

8

High-throughput

0.691

High

863142

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

132268

DLL1
Delta-like protein 1

1

16

Small-scale

0.647

High

235616

VINEX
Vinexin

1

6

Small-scale

0.647

High

1054800

CASL
Enhancer of filamentation 1

1

4

Small-scale

0.647

High

1059044

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

20

Small-scale

0.647

High

1267686

MAML1
Mastermind-like protein 1

1

13

Small-scale

0.647

High

1357251

JAG2
Protein jagged-2

1

18

Small-scale

0.647

High

1357253

NEUR2
Sialidase-2

3

0

High-throughput

0.638

High

1253280

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

2

7

High-throughput

0.628

High

1349252

ZN224
Zinc finger protein 224

2

6

High-throughput

0.628

High

612912

FBLN1
Fibulin-1

1

18

High-throughput

0.621

High

1355435

EGFL7
Epidermal growth factor-like protein 7

1

19

Small-scale

0.621

High

1166467

BTNL3
Butyrophilin-like protein 3

1

6

High-throughput

0.618

High

337591

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.618

High

557825

NCK1
SH2/SH3 adapter protein NCK1

1

5

High-throughput

0.618

High

836084

GSK3B
Glycogen synthase kinase-3 beta

1

9

Small-scale

0.618

High

992726

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

17

Small-scale

0.618

High

237857

TSN3
Tetraspanin-3

3

1

High-throughput

0.609

High

1237988

ZFP41
Zinc finger protein 41 homolog

3

18

High-throughput

0.609

High

887075

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1260443

S20A1
Sodium-dependent phosphate transporter 1

2

0

High-throughput

0.602

High

1328984

ABCG8
ATP-binding cassette sub-family G member 8

2

0

High-throughput

0.602

High

857934

CRIP2
Cysteine-rich protein 2

1

3

Small-scale

0.579

High

125785

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

13

Small-scale

0.578

High

1220500

DJC10
DnaJ homolog subfamily C member 10

2

2

High-throughput

0.574

High

1295426

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

6

High-throughput

0.574

High

1317663

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

2

13

High-throughput

0.574

High

1334230

ZN408
Zinc finger protein 408

2

20

High-throughput

0.574

High

830056

HXA1
Homeobox protein Hox-A1

1

20

High-throughput

0.541

High

1189971

NUFP2
FMR1-interacting protein NUFIP2

1

2

High-throughput

0.541

High

1355890

MBD1
Methyl-CpG-binding domain protein 1

1

4

High-throughput

0.541

High

449386

LEG1
Galectin-1

1

4

High-throughput

0.536

High

984287

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

1

High-throughput

0.536

High

1032359

MFAP5
Microfibrillar-associated protein 5

1

3

High-throughput

0.536

High

1083645

ZNF74
Zinc finger protein 74

1

18

High-throughput

0.536

High

1253739

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

5

High-throughput

0.536

High

1259461

NET5
Netrin-5

1

12

High-throughput

0.536

High

1332767

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.536

High

1335626

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.536

High

1345594

IGSF5
Immunoglobulin superfamily member 5

1

2

High-throughput

0.536

High

1356241

FBX2
F-box only protein 2

1

9

High-throughput

0.536

High

526545

IL7
Interleukin-7

1

0

High-throughput

0.513

High

1189995

KCNKI
Potassium channel subfamily K member 18

1

0

High-throughput

0.513

High

1357255

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

320473

CPNE6
Copine-6

1

1

Small-scale

0.501

High

324117

BAG2
BAG family molecular chaperone regulator 2

1

1

Small-scale

0.501

High

348223

MYC
Myc proto-oncogene protein

1

6

Small-scale

0.501

High

434309

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.501

High

923809

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

Small-scale

0.501

High

1039935

SNW1
SNW domain-containing protein 1

1

1

Small-scale

0.501

High

1348138

S39A1
Zinc transporter ZIP1

1

1

Small-scale

0.501

High

1166401

IGFL3
Insulin growth factor-like family member 3

1

4

High-throughput

0.489

High

1240834

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.489

High

1286315

ZN707
Zinc finger protein 707

1

20

High-throughput

0.489

High

931936

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

174249

SPTC2
Serine palmitoyltransferase 2

1

0

Small-scale

0.480

High

203473

MTG8R
Protein CBFA2T2

1

0

Small-scale

0.480

High

532646

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.480

High

799453

TNNT2
Troponin T, cardiac muscle

1

0

Small-scale

0.480

High

1289056

RMI2
RecQ-mediated genome instability protein 2

1

0

Small-scale

0.480

High

1332238

XKR8
XK-related protein 8

1

0

Small-scale

0.480

High

206161

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

385709

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

522266

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

610534

CBL
E3 ubiquitin-protein ligase CBL

1

5

Small-scale

0.479

High

781263

CASR
Extracellular calcium-sensing receptor

1

2

Small-scale

0.479

High

1042830

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1200375

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

8

High-throughput

0.479

High

1269922

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1357252

STRAP
Serine-threonine kinase receptor-associated protein

1

9

Small-scale

0.479

High

953060

PR20D
Proline-rich protein 20D

1

2

High-throughput

0.470

High

637602

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.458

High

280166

C1QRF
C1q-related factor

1

1

Small-scale

0.457

High

1145538

WDR25
WD repeat-containing protein 25

1

4

Small-scale

0.457

High

1266795

SNX19
Sorting nexin-19

1

1

Small-scale

0.457

High

1295763

BT3L4
Transcription factor BTF3 homolog 4

1

2

Small-scale

0.457

High

135304

E2F3
Transcription factor E2F3

1

1

Small-scale

0.445

High

953138

PR20A
Proline-rich protein 20A

1

2

High-throughput

0.439

High

1333649

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.328

High

891479

CTXN1
Cortexin-1

1

0

High-throughput

0.279

Low

1078455

MPPD2
Metallophosphoesterase MPPED2

1

0

Small-scale

0.261

Low

1159845

GGT6
Glutathione hydrolase 6

1

0

Small-scale

0.261

Low

1166480

TM108
Transmembrane protein 108

1

0

Small-scale

0.261

Low

1237359

CNTD1
Cyclin N-terminal domain-containing protein 1

1

0

Small-scale

0.261

Low

1295797

CH076
Uncharacterized protein C8orf76

1

0

Small-scale

0.261

Low

1300527

SG3A1
Secretoglobin family 3A member 1

1

0

Small-scale

0.261

Low

1153659

PTCRA
Pre T-cell antigen receptor alpha

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024