HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.939

The method score is based on:

Property Details
Experiments 23453969, 10421793, 19481526, 14743216, 21822257, 19153231
Identification Methods affinity chromatography technology, in-gel kinase assay, tandem affinity purification, protein kinase assay
Interaction Type physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~TBK1_CCD1, Pkinase~TBK1_ULD, TBK1_CCD1~TBK1_CCD1, TBK1_CCD1~TBK1_ULD, TBK1_ULD~TBK1_ULD
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 23 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024