Protein: AEN
Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)

Gene: AEN
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q8WTP8

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0004527 - exonuclease activity
GO:0004529 - DNA exonuclease activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1116767

AAMP
Angio-associated migratory cell protein

7

3

High-throughput

0.683

High

1311758

HOMEZ
Homeobox and leucine zipper protein Homez

2

2

High-throughput

0.633

High

1355864

ZN473
Zinc finger protein 473

2

2

High-throughput

0.628

High

1355869

ZN317
Zinc finger protein 317

2

2

High-throughput

0.628

High

1355871

LZTS2
Leucine zipper putative tumor suppressor 2

3

5

High-throughput

0.616

High

928205

HAP1
Huntingtin-associated protein 1

2

2

High-throughput

0.606

High

1355872

ZN408
Zinc finger protein 408

2

3

High-throughput

0.606

High

1355875

ZF64B
Zinc finger protein 64

2

2

High-throughput

0.596

High

212853

ZBT43
Zinc finger and BTB domain-containing protein 43

1

2

High-throughput

0.573

High

515847

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

5

High-throughput

0.573

High

572095

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.573

High

894931

EMD
Emerin

1

1

High-throughput

0.573

High

1104619

IKZF1
DNA-binding protein Ikaros

1

3

High-throughput

0.573

High

1148282

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

1

5

High-throughput

0.573

High

1205904

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

3

High-throughput

0.573

High

1217979

MYOME
Myomegalin

1

2

High-throughput

0.573

High

1286207

RALYL
RNA-binding Raly-like protein

1

6

High-throughput

0.573

High

1355865

TRI41
E3 ubiquitin-protein ligase TRIM41

1

3

High-throughput

0.573

High

1355867

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

4

High-throughput

0.573

High

1225023

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

1

High-throughput

0.553

High

1061787

TLE5
TLE family member 5

1

0

High-throughput

0.549

High

1219125

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.549

High

1312469

PHC2
Polyhomeotic-like protein 2

1

0

High-throughput

0.549

High

1355866

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.549

High

1355877

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

1064892

PPID
Peptidyl-prolyl cis-trans isomerase D

1

1

High-throughput

0.536

High

1130795

RRP5
Protein RRP5 homolog

1

3

High-throughput

0.536

High

950349

KR107
Keratin-associated protein 10-7

1

5

High-throughput

0.523

High

950596

KR108
Keratin-associated protein 10-8

1

5

High-throughput

0.523

High

1230165

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.523

High

1355868

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

3

High-throughput

0.523

High

1355876

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

3

High-throughput

0.523

High

1290569

Q86VM6
MBNL1 protein

1

1

High-throughput

0.515

High

1157476

PKN1
Serine/threonine-protein kinase N1

1

0

High-throughput

0.513

High

915906

CRIP2
Cysteine-rich protein 2

1

1

High-throughput

0.489

High

1355874

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.481

High

372670

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

91678

C9JG97
Angio-associated migratory cell protein

1

3

High-throughput

0.470

High

950104

KR105
Keratin-associated protein 10-5

1

5

High-throughput

0.470

High

227622

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

1355870

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.460

High

1088926

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

949752

KR101
Keratin-associated protein 10-1

1

5

High-throughput

0.439

High

949950

KR103
Keratin-associated protein 10-3

1

5

High-throughput

0.439

High

1188009

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.299

High

608313

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1214350

SYT6
Synaptotagmin-6

1

0

High-throughput

0.268

Low

1355873

SEM4B
Semaphorin-4B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025