HitPredict

Interactor 1: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 351
+	Hs
		438164 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431843 IKKE_HUMAN (1-716): 1.32e-170: 508: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438593 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432334 TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		158374 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		158371 IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		1123982 Q59GT1_HUMAN (9-686): 6.87e-117: 369: 18.72		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		167449 IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431932 Q59GT1_HUMAN (9-686): 6.87e-117: 369: 18.72		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		167446 IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		1123962 Q59GL9_HUMAN (61-520): 3.28e-112: 349: 22.57		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		438190 KS6A2_HUMAN (6-290): 2.47e-89: 297: 21.95		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438011 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438601 KS6A6_HUMAN (7-307): 1.97e-88: 294: 20.07		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431873 KS6A2_HUMAN (6-290): 2.47e-89: 297: 21.95		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		538459 MRCKB_HUMAN (7-705): 4e-115: 382: 17.25		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		431672 KS6A3_HUMAN (6-294): 2.42e-88: 294: 22.34		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		432343 KS6A6_HUMAN (7-307): 1.97e-88: 294: 20.07		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Zm
		24080 A0A1D6ICZ3_MAIZE (3-466): 2.8e-121: 374: 16.14		A0A1D6LMW9_MAIZE (5-348): 2.19e-139: 416: 50.43
+	Sc
		365561 SNF1_YEAST (9-487): 5.7e-101: 325: 17.23		HSP82_YEAST (11-350): 7.63e-148: 435: 66.86