Protein: PNP
Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase)

Gene: PNP
Organism: Escherichia coli K-12
Interactions: 49
UniProt ID: P05055

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004654 - polyribonucleotide nucleotidyltransferase activity
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

421122

RNE
Ribonuclease E

7

0

Small-scale

0.907

High

421088

PNP
Polyribonucleotide nucleotidyltransferase

2

20

Small-scale

0.768

High

421128

RL24
Large ribosomal subunit protein uL24

2

0

High-throughput

0.720

High

421121

SRMB
ATP-dependent RNA helicase SrmB

3

6

High-throughput

0.669

High

382613

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.656

High

421108

CSPE
Cold shock-like protein CspE

3

8

High-throughput

0.643

High

421117

RL17
Large ribosomal subunit protein bL17

3

1

High-throughput

0.643

High

421125

RLMN
Dual-specificity RNA methyltransferase RlmN

2

1

High-throughput

0.611

High

421093

RL1
Large ribosomal subunit protein uL1

2

7

High-throughput

0.588

High

421096

RS18
Small ribosomal subunit protein bS18

2

1

High-throughput

0.588

High

421098

RS20
Small ribosomal subunit protein bS20

2

1

High-throughput

0.588

High

421099

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.588

High

421100

RS4
Small ribosomal subunit protein uS4

2

1

High-throughput

0.588

High

421112

RL13
Large ribosomal subunit protein uL13

2

2

High-throughput

0.588

High

421120

IBPA
Small heat shock protein IbpA

2

1

High-throughput

0.588

High

421127

RL2
Large ribosomal subunit protein uL2

2

3

High-throughput

0.588

High

421129

RL4
Large ribosomal subunit protein uL4

2

1

High-throughput

0.588

High

421131

RL5
Large ribosomal subunit protein uL5

2

1

High-throughput

0.588

High

361731

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.585

High

421106

RHLB
ATP-dependent RNA helicase RhlB

2

7

Small-scale

0.583

High

421091

PGK
Phosphoglycerate kinase

2

0

High-throughput

0.563

High

421094

RL9
Large ribosomal subunit protein bL9

2

0

High-throughput

0.563

High

421095

RS13
Small ribosomal subunit protein uS13

2

0

High-throughput

0.563

High

421097

RS19
Small ribosomal subunit protein uS19

2

0

High-throughput

0.563

High

421115

DBHA
DNA-binding protein HU-alpha

2

0

High-throughput

0.563

High

421116

RS15
Small ribosomal subunit protein uS15

2

0

High-throughput

0.563

High

421118

RL21
Large ribosomal subunit protein bL21

2

0

High-throughput

0.563

High

421126

RLUB
Ribosomal large subunit pseudouridine synthase B

1

3

High-throughput

0.561

High

421105

YACL
UPF0231 protein YacL

2

1

High-throughput

0.537

High

421101

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

421124

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

1

High-throughput

0.536

High

421123

MURE
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

1

0

High-throughput

0.513

High

421089

ENO
Enolase

1

1

High-throughput

0.484

High

421090

HFQ
RNA-binding protein Hfq

1

1

High-throughput

0.484

High

421103

RPOA
DNA-directed RNA polymerase subunit alpha

1

1

High-throughput

0.484

High

421107

CSPD
Cold shock-like protein CspD

1

8

High-throughput

0.484

High

421111

CSPC
Cold shock-like protein CspC

1

8

High-throughput

0.484

High

421113

YBCJ
Putative RNA-binding protein YbcJ

1

1

High-throughput

0.484

High

421130

RL22
Large ribosomal subunit protein uL22

1

2

High-throughput

0.484

High

421102

RNPA
Ribonuclease P protein component

1

1

High-throughput

0.479

High

421109

DEAD
ATP-dependent RNA helicase DeaD

1

5

High-throughput

0.479

High

421104

METK
S-adenosylmethionine synthase

1

0

High-throughput

0.464

High

421119

RL6
Large ribosomal subunit protein uL6

1

0

High-throughput

0.464

High

421132

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

421092

RECA
Protein RecA

1

1

High-throughput

0.442

High

421110

MREB
Cell shape-determining protein MreB

1

10

High-throughput

0.442

High

421114

PCNB
Poly(A) polymerase I

1

0

Small-scale

0.426

High

383981

RL15
Large ribosomal subunit protein uL15

3

0

High-throughput

0.342

High


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Last updated: 11Aug2025