HitPredict

Interactor 1: MPP2 (Q14168)
MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2)
Gene: MPP2

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.894

Property	Details
Experiments	28514442, 33961781, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 576 Hs			1 207
+	Hs
		1050418 MPP2_HUMAN (1-576): 0: 576: 100.00		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158282 MPP2_HUMAN (1-576): 0: 576: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		1334778 PALS2_HUMAN (12-576): 6.79e-176: 510: 66.31		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		1346107 PALS2_HUMAN (12-576): 6.79e-176: 510: 66.31		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158304 PALS2_HUMAN (12-576): 6.79e-176: 510: 66.31		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		1021489 MPP2_HUMAN (1-576): 0: 576: 100.00		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Dm
		116476 M9PJD0_DROME (134-576): 4.61e-157: 495: 33.13		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Mm
		1143555 MPP2_MOUSE (1-576): 0: 543: 93.40		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Mm
		251089 CSKP_MOUSE (7-576): 6.08e-145: 443: 36.50		LIN7B_MOUSE (1-207): 1.88e-63: 197: 98.07
+	Hs
		159269 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		159277 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Mm
		251090 CSKP_MOUSE (7-576): 6.08e-145: 443: 36.50		LIN7C_MOUSE (1-196): 9.63e-58: 182: 84.69
+	Dm
		1096800 CSKP_DROME (11-576): 3.67e-148: 450: 37.78		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Hs
		158254 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		159203 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		SNTB2_HUMAN (2-207): 1.48e-36: 135: 28.10
+	Hs
		159207 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		SNTB1_HUMAN (2-206): 4.53e-34: 128: 23.94
+	Hs
		159110 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		CSKP_HUMAN (10-206): 4.77e-31: 121: 20.00
+	Hs
		159190 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Hs
		159200 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Hs
		159249 CSKP_HUMAN (7-576): 4.46e-145: 443: 36.50		DLG3_HUMAN (29-164): 2.29e-20: 90.3: 25.53