Protein: UBE3C
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)

Gene: UBE3C
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q15386

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000502 - proteasome complex
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0035519 - protein K29-linked ubiquitination
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906670

UB2D1
Ubiquitin-conjugating enzyme E2 D1

7

20

Small-scale

0.964

High

1147516

UBE3C
Ubiquitin-protein ligase E3C

7

16

Small-scale

0.959

High

995962

UB2L3
Ubiquitin-conjugating enzyme E2 L3

6

20

Small-scale

0.942

High

982191

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.888

High

508015

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

20

Small-scale

0.841

High

957082

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

1050428

UBE3A
Ubiquitin-protein ligase E3A

2

15

Small-scale

0.737

High

1097992

PSMD2
26S proteasome non-ATPase regulatory subunit 2

4

9

Small-scale

0.692

High

138122

PSDE
26S proteasome non-ATPase regulatory subunit 14

4

16

Small-scale

0.676

High

954693

SEM1
26S proteasome complex subunit SEM1

3

3

Small-scale

0.650

High

262235

SCN2B
Sodium channel regulatory subunit beta-2

4

2

High-throughput

0.630

High

970548

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1147521

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

20

Small-scale

0.618

High

1147585

HECD1
E3 ubiquitin-protein ligase HECTD1

1

18

High-throughput

0.618

High

933646

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

9

High-throughput

0.611

High

1136521

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

12

Small-scale

0.611

High

968931

PRS8
26S proteasome regulatory subunit 8

2

18

Small-scale

0.595

High

1147588

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

5

High-throughput

0.593

High

1147573

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

20

Small-scale

0.579

High

1063267

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.578

High

1147590

ASB4
Ankyrin repeat and SOCS box protein 4

1

9

High-throughput

0.575

High

60718

F234B
Protein FAM234B

2

1

High-throughput

0.574

High

1147526

ANR55
Ankyrin repeat domain-containing protein 55

1

10

High-throughput

0.553

High

1147530

DDI2
Protein DDI1 homolog 2

1

14

High-throughput

0.553

High

1147567

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

8

High-throughput

0.553

High

333016

VAPB
Vesicle-associated membrane protein-associated protein B/C

2

3

High-throughput

0.549

High

127970

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

10

High-throughput

0.536

High

128236

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

7

High-throughput

0.536

High

210955

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

3

High-throughput

0.536

High

610337

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.536

High

633687

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.536

High

680883

PSA1
Proteasome subunit alpha type-1

1

16

High-throughput

0.536

High

700644

PSA5
Proteasome subunit alpha type-5

1

17

High-throughput

0.536

High

701034

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.536

High

778688

PRS7
26S proteasome regulatory subunit 7

1

14

High-throughput

0.536

High

851327

PRS6B
26S proteasome regulatory subunit 6B

1

13

High-throughput

0.536

High

887534

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.536

High

887659

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.536

High

954815

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.536

High

975407

PRS10
26S proteasome regulatory subunit 10B

1

18

High-throughput

0.536

High

1147556

PSB7
Proteasome subunit beta type-7

1

18

High-throughput

0.536

High

1147557

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

9

High-throughput

0.536

High

1147586

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

5

High-throughput

0.536

High

413883

P53
Cellular tumor antigen p53

2

18

Small-scale

0.533

High

1147542

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.528

High

914419

EFNB2
Ephrin-B2

2

2

High-throughput

0.521

High

186755

P73
Tumor protein p73

1

18

Small-scale

0.512

High

316865

MTA2
Metastasis-associated protein MTA2

1

7

High-throughput

0.494

High

1147584

TLK1
Serine/threonine-protein kinase tousled-like 1

1

20

High-throughput

0.494

High

573833

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.489

High

62120

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

2

High-throughput

0.489

High

182540

GP182
G-protein coupled receptor 182

1

11

High-throughput

0.489

High

291796

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.489

High

337350

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.489

High

372094

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.489

High

380428

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.489

High

407096

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.489

High

520854

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

563804

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.489

High

634759

GRAH
Granzyme H

1

7

High-throughput

0.489

High

640174

EPHA1
Ephrin type-A receptor 1

1

9

High-throughput

0.489

High

699551

IL1R2
Interleukin-1 receptor type 2

1

5

High-throughput

0.489

High

725498

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

5

High-throughput

0.489

High

732980

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

2

High-throughput

0.489

High

1120016

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

6

High-throughput

0.489

High

1134858

PSME4
Proteasome activator complex subunit 4

1

1

High-throughput

0.489

High

1142060

P2RY6
P2Y purinoceptor 6

1

9

High-throughput

0.489

High

1147518

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.489

High

1147523

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

11

High-throughput

0.489

High

1147529

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

1147538

DDX60
Probable ATP-dependent RNA helicase DDX60

1

12

High-throughput

0.489

High

1147539

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.489

High

1147541

ARRD4
Arrestin domain-containing protein 4

1

20

High-throughput

0.489

High

1147543

ARRD2
Arrestin domain-containing protein 2

1

20

High-throughput

0.489

High

1147546

CLC2B
C-type lectin domain family 2 member B

1

2

High-throughput

0.489

High

1147550

ARRD3
Arrestin domain-containing protein 3

1

20

High-throughput

0.489

High

1147552

RMXL1
RNA binding motif protein, X-linked-like-1

1

11

High-throughput

0.489

High

1147553

AURKB
Aurora kinase B

1

15

High-throughput

0.489

High

1147562

CNTP3
Contactin-associated protein-like 3

1

12

High-throughput

0.489

High

1147564

F234A
Protein FAM234A

1

1

High-throughput

0.489

High

1147566

TXNIP
Thioredoxin-interacting protein

1

20

High-throughput

0.489

High

1147574

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.489

High

1147577

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

3

High-throughput

0.489

High

1147581

CLC2D
C-type lectin domain family 2 member D

1

2

High-throughput

0.489

High

1147587

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

1

High-throughput

0.489

High

1147593

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

681168

PSA2
Proteasome subunit alpha type-2

1

20

Small-scale

0.479

High

700891

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.479

High

1106900

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1113169

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1115203

CUL4B
Cullin-4B

1

10

High-throughput

0.479

High

1147517

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

3

High-throughput

0.479

High

1147592

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

Small-scale

0.479

High

317846

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

1147535

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.458

High

1147575

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.458

High

273194

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

10

Small-scale

0.457

High

422139

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.457

High

1147583

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.445

High

1087397

GRSF1
G-rich sequence factor 1

1

20

Small-scale

0.439

High

130111

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

238528

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.437

High

277360

TP4A3
Protein tyrosine phosphatase type IVA 3

1

13

High-throughput

0.437

High

363320

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.437

High

377577

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

396165

ESR1
Estrogen receptor

1

20

Small-scale

0.437

High

411977

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.437

High

452267

PDIA1
Protein disulfide-isomerase

1

12

Small-scale

0.437

High

474694

VIME
Vimentin

1

8

Small-scale

0.437

High

542039

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.437

High

555690

ACTN1
Alpha-actinin-1

1

5

Small-scale

0.437

High

565913

EF2
Elongation factor 2

1

11

Small-scale

0.437

High

573112

KPYM
Pyruvate kinase PKM

1

8

Small-scale

0.437

High

573487

ENPL
Endoplasmin

1

16

Small-scale

0.437

High

576656

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

2

High-throughput

0.437

High

588764

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

607591

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

8

High-throughput

0.437

High

611733

BMP7
Bone morphogenetic protein 7

1

2

Small-scale

0.437

High

627973

ANXA7
Annexin A7

1

13

Small-scale

0.437

High

646848

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.437

High

680366

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

9

Small-scale

0.437

High

687423

PTBP1
Polypyrimidine tract-binding protein 1

1

9

Small-scale

0.437

High

695530

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

697889

CALR
Calreticulin

1

7

Small-scale

0.437

High

705703

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

4

High-throughput

0.437

High

717308

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

Small-scale

0.437

High

717484

PDIA3
Protein disulfide-isomerase A3

1

12

Small-scale

0.437

High

731323

STIP1
Stress-induced-phosphoprotein 1

1

16

High-throughput

0.437

High

772816

MYH9
Myosin-9

1

2

Small-scale

0.437

High

799139

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.437

High

830786

CCNF
Cyclin-F

1

7

High-throughput

0.437

High

848264

MAGA3
Melanoma-associated antigen 3

1

13

Small-scale

0.437

High

939925

TPTE
Putative tyrosine-protein phosphatase TPTE

1

13

High-throughput

0.437

High

941908

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.437

High

965688

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

18

Small-scale

0.437

High

996164

EF1A1
Elongation factor 1-alpha 1

1

7

Small-scale

0.437

High

1031384

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.437

High

1067357

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.437

High

1068215

AHNK
Neuroblast differentiation-associated protein AHNAK

1

5

Small-scale

0.437

High

1102548

MTA1
Metastasis-associated protein MTA1

1

7

Small-scale

0.437

High

1104191

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

6

High-throughput

0.437

High

1106545

SMAD4
Mothers against decapentaplegic homolog 4

1

20

High-throughput

0.437

High

1124336

ELOA1
Elongin-A

1

3

Small-scale

0.437

High

1146673

PCBP1
Poly(rC)-binding protein 1

1

17

Small-scale

0.437

High

1147520

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

High-throughput

0.437

High

1147522

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

3

High-throughput

0.437

High

1147524

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1147531

MYOME
Myomegalin

1

9

High-throughput

0.437

High

1147534

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1147545

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.437

High

1147549

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

4

High-throughput

0.437

High

1147551

FAF2
FAS-associated factor 2

1

10

High-throughput

0.437

High

1147554

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.437

High

1147558

TCPH
T-complex protein 1 subunit eta

1

15

Small-scale

0.437

High

1147559

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

10

High-throughput

0.437

High

1147563

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.437

High

1147569

ECT2
Protein ECT2

1

7

High-throughput

0.437

High

1147571

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.437

High

1147576

PD1L1
Programmed cell death 1 ligand 1

1

9

High-throughput

0.437

High

1147580

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.437

High

1147582

HOOK1
Protein Hook homolog 1

1

9

High-throughput

0.437

High

97247

E9PS44
Interferon induced transmembrane protein 3

1

5

High-throughput

0.407

High

166307

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

6

High-throughput

0.407

High

212405

SPIT2
Kunitz-type protease inhibitor 2

1

7

High-throughput

0.407

High

296615

TNF13
Tumor necrosis factor ligand superfamily member 13

1

1

High-throughput

0.407

High

379517

IGHM
Immunoglobulin heavy constant mu

1

4

High-throughput

0.407

High

380041

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.407

High

516341

CALM1
Calmodulin-1

1

13

High-throughput

0.407

High

516415

CALM2
Calmodulin-2

1

13

High-throughput

0.407

High

516521

CALM3
Calmodulin-3

1

13

High-throughput

0.407

High

886059

CXCR3
C-X-C chemokine receptor type 3

1

8

High-throughput

0.407

High

956873

CXCR4
C-X-C chemokine receptor type 4

1

9

High-throughput

0.407

High

1048357

ACVR1
Activin receptor type-1

1

20

High-throughput

0.407

High

1147525

P3H1
Prolyl 3-hydroxylase 1

1

3

High-throughput

0.407

High

1147527

S45A4
Solute carrier family 45 member 4

1

1

High-throughput

0.407

High

1147528

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.407

High

1147532

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

1147536

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

3

High-throughput

0.407

High

1147537

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

6

High-throughput

0.407

High

1147547

S39A7
Zinc transporter SLC39A7

1

3

High-throughput

0.407

High

1147560

S39A3
Zinc transporter ZIP3

1

3

High-throughput

0.407

High

1147572

TMM9B
Transmembrane protein 9B

1

3

High-throughput

0.407

High

1147589

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.407

High

388203

GLPA
Glycophorin-A

2

0

High-throughput

0.313

High

1147544

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

Small-scale

0.292

High

71209

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

139216

UPK2
Uroplakin-2

1

0

High-throughput

0.279

Low

486561

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.279

Low

564911

ICAM2
Intercellular adhesion molecule 2

1

0

High-throughput

0.279

Low

749204

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

749331

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

821717

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.279

Low

1147519

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1147533

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1147540

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1147555

OPALI
Opalin

1

0

High-throughput

0.279

Low

1147565

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1147570

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.279

Low

1147578

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1147579

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.279

Low

1147591

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

1147594

KCMB2
Calcium-activated potassium channel subunit beta-2

1

0

High-throughput

0.279

Low

660265

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.268

Low

390051

ALBU
Albumin

1

0

Small-scale

0.249

Low

663417

RIR1
Ribonucleoside-diphosphate reductase large subunit

1

0

Small-scale

0.249

Low

1147548

FAM3C
Protein FAM3C

1

0

Small-scale

0.249

Low

1147561

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.249

Low

469484

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low

1147568

PACC1
Proton-activated chloride channel

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025